Zobrazeno 1 - 10
of 647
pro vyhledávání: '"Hisao Masai"'
Autor:
Zhiying You, Hisao Masai
Publikováno v:
Biology, Vol 13, Iss 8, p 629 (2024)
In this review, we summarize the processes of the assembly of multi-protein replisomes at the origins of replication. Replication licensing, the loading of inactive minichromosome maintenance double hexamers (dhMCM2-7) during the G1 phase, is followe
Externí odkaz:
https://doaj.org/article/6edabcb6f52543b6800ba6884e04339e
Autor:
Tamas Nemeth, Naoko Yoshizawa-Sugata, Agnes Pallier, Youichi Tajima, Yue Ma, Éva Tóth, Hisao Masai, Yoko Yamakoshi
Publikováno v:
Chemical & Biomedical Imaging, Vol 1, Iss 2, Pp 157-167 (2023)
With the aim of developing more stable Gd(III)–porphyrin complexes, two types of ligands 1 and 2 with carboxylic acid anchors were synthesized. Due to the N-substituted pyridyl cation attached to the porphyrin core, these porphyrin ligands were h
Externí odkaz:
https://doaj.org/article/b687f69bb95f41b6957bf4209229513e
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
The histone H3K27 demethylase, UTX/KDM6A, plays a critical role in the early development of vertebrates, and mutations are frequently found in various cancers. Several studies on developmental and cancer biology have focused on preferential transcrip
Externí odkaz:
https://doaj.org/article/ac19b9687676421585622fd8dc156a70
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1145 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/febf2c6b7312447a8dc4778b1cb59113
Autor:
Shojiro Kitajima, Wendi Sun, Kian Leong Lee, Jolene Caifeng Ho, Seiichi Oyadomari, Takashi Okamoto, Hisao Masai, Lorenz Poellinger, Hiroyuki Kato
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers. Although UTX appears to play a crucial role in oncogenesis, the mechanisms involved are still largely unknown. H
Externí odkaz:
https://doaj.org/article/269f3fc324ab4ebb93a68e6e694339e8
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 125 (2023)
Replication stress has been suggested to be an ultimate trigger of carcinogenesis. Oncogenic signal, such as overexpression of CyclinE, has been shown to induce replication stress. Here, we show that various biological stresses, including heat, oxida
Externí odkaz:
https://doaj.org/article/83ee0734e0304a62875dd505ff62cc1d
Autor:
Koutarou Nakamura, Seiichiro Sakai, Jun Tsuyama, Akari Nakamura, Kento Otani, Kumiko Kurabayashi, Yoshiko Yogiashi, Hisao Masai, Takashi Shichita
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3000939 (2021)
Inflammation is implicated in the onset and progression of various diseases, including cerebral pathologies. Here, we report that DJ-1, which plays a role within cells as an antioxidant protein, functions as a damage-associated molecular pattern (DAM
Externí odkaz:
https://doaj.org/article/1de6d36db1674a9f96fa3f621d7d2726
Autor:
Hisao Masai, Chi-Chun Yang
Publikováno v:
Molecular and Cellular Biology. 43:1-21
Publikováno v:
eLife, Vol 8 (2019)
Replication checkpoint is essential for maintaining genome integrity in response to various replication stresses as well as during the normal growth. The evolutionally conserved ATR-Claspin-Chk1 pathway is induced during replication checkpoint activa
Externí odkaz:
https://doaj.org/article/df8701775c3043629a30ed5870457236
Autor:
Chi-Chun Yang, Masahiro Suzuki, Shiori Yamakawa, Syuzi Uno, Ai Ishii, Satoshi Yamazaki, Rino Fukatsu, Ryo Fujisawa, Kenji Sakimura, Toshiki Tsurimoto, Hisao Masai
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Claspin mediates the transmission of a replication-stress signal from ATR to Chk1 and is necessary for efficient fork progression. Here the authors demonstrate that the C-terminal acidic patch is important for this role due to its interaction with Cd
Externí odkaz:
https://doaj.org/article/80ded932439f424cb6a70a103797b95e