Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Hisao Ekimoto"'
Publikováno v:
Biologicalpharmaceutical bulletin. 42(3)
Combination therapy is often an effective strategy to treat cancer. In this study, we examined the growth-inhibitory effects of Am80 (tamibarotene), a specific retinoic acid receptor (RAR) α/β agonist, in combination with a histone deacetylase (HDA
Autor:
Asami Yamaguchi, Hisao Ekimoto, Hidetoshi Nakatake, Mariko Aso, Hiroshi Suemune, Atsushi Ogawa
Publikováno v:
Chemical and Pharmaceutical Bulletin. 59:710-713
Bisphosphonates have high affinity for hydroxyapatite (HA), which is abundantly present in bone. Also, platinum complexes are known that have a wide spectrum of antitumor activities. The conjugate of bisphosphonate and a platinum complex might have H
Autor:
Ken Yamaguchi, Mineaki Okada, Rie Tanaka, Tohru Mochizuki, Naoko Kajimura, Noboru Yanaihara, Hisao Ekimoto, Koich Nagasaki
Publikováno v:
Biomedical Research. 17:379-384
Publikováno v:
Cancer Chemotherapy and Pharmacology. 36:459-462
The antitumor activity of cytarabine ocfosfate (SPAC) was tested against human colorectal, gastric and lung adenocarcinoma xenografts in nude mice in comparison with the activities of various antitumor drugs used clinically. SPAC showed higher therap
Autor:
Kayoko S. Tsuchiya, Tomio Takeuchi, Toshie Kanbe, Yoshikazu Takahashi, Hisao Ekimoto, Makoto Hori
Publikováno v:
Biological and Pharmaceutical Bulletin. 17:527-530
Several antitumor anthracyclines, including those in preclinical stages, were examined for their action in reversing tumorous phenotypes of H- or K-ras 3T3 cells (NIH3T3 cells transformed by human H- or K-ras oncogene) into normal phenotypes, such as
Autor:
Masayuki Yokoyama, Kazunori Kataoka, Glenn S. Kwon, Hiroko Mashiba, Teruo Okano, Yasuhisa Sakurai, Kazuya Okamoto, Hisao Ekimoto, Takashi Seto
Publikováno v:
Drug Delivery. 1:11-19
Micelle-forming block copolymer–drug conjugates, Adriamycin-conjugated polyethylene glycol–poly(aspartic acid) block copolymers (PEG-P[Asp(ADR)]), were synthesized in eight compositions with varying chain lengths of the segments constituting the
Autor:
Kiyoyuki Yamada, Yoshifumi Yoshida, Takeshi Ishigaki, Hisao Ekimoto, Makoto Ojika, Masayuki Arakawa
Publikováno v:
ChemInform. 25
Autor:
Takashi Tsuruo, Katsutoshi Takahashi, Yoshiteru Terashima, Masanori Fukushima, Hiroshi Sasaki, Hisao Ekimoto, Kimihiko Takada
Publikováno v:
Gynecologic Oncology. 41:36-40
The antitumor activity of Δ 7 -prostaglandin A 1 (Δ 7 -PGA 1 ) or Δ 12 -prostaglandin J 2 (Δ 7 -PGJ 2 ) on human ovarian cancer cell lines resistant to cisplatin (CDDP), doxorubicin (ADR), and l-phenylalanine mustard (1-PAM) was studied in vitro
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:639-651
Eighteen new tetranortriterpenoids were isolated from the cotyledons of Swietenia mahagoni (Meliaceae) along with the known tetranortriterpenoids. Among them, the structures of wight new compounds, swietenins B, C, D, E, and F, 3-O-acetylswietenolide
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:894-901
Eight new tetranortriterpenoids, swietemahonin A-G and swietemahonolide, were isolated from the cotyledons of seeds of Swietenia mahagoni. The structures 1-8 are proposed for these compounds, respectively, based mainly on detailed analyses of the pro