Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Hisamaru Hirai"'
Autor:
Yasuo Morishima, Hisamaru Hirai, Yoshiko Atsuta, Masamichi Hara, Keitaro Matsuo, Hiroshi Sao, Shinichiro Okamoto, Heiwa Kanamori, Tohru Murayama, Yoshihisa Kodera, Tetsuya Nishida
Publikováno v:
International Journal of Hematology. 89:98-105
Bone marrow transplantation from unrelated donors (UR-BMT) has been considered to be effective for patients with hematological malignancies who have no suitable related donor. However, disparities of HLA between a recipient and a donor increase the r
Autor:
Motoko Fujisawa, Masako Ozai, Mineo Kurokawa, Yukiko Komeno, Tatsushi Osawa, Kazuo Kubo, Tomoaki Kuwaki, Atsushi Miwa, Hisamaru Hirai, Tetsuya Yoshino, Yuko Ogasawara, Shigeru Chiba, Seishi Ogawa, Rieko Yoshioka, Uichi Nishiyama, Miyuki Kitahori, Eiji Yoshioka
Publikováno v:
Leukemia Research. 30:1541-1546
Activating mutations of Fms-like tyrosine kinase 3 (Flt3) are the most common genetic abnormalities found in acute myeloid leukemia (AML) and represent potential therapeutic targets. The novel Flt3 inhibitor KRN383 inhibited the autophosphorylation o
Autor:
Yoshinobu Kanda, Hisamaru Hirai, Kiyoshi Hiruma, Kimiko Iijima, Satoshi Yoshihara, Toshihiko Ando, Tamae Hamaki, Yukiko Komeno, Hisashi Sakamaki, Sung-Won Kim, Masahiro Kami, Kinuko Mitani, Koichiro Yuji, Shinichiro Mori, Emi Yamamoto, Junichi Ueyama
Publikováno v:
Biology of Blood and Marrow Transplantation. 12:408-413
Although the mobilization of peripheral blood stem cells from normal donors using granulocyte colony-stimulating factor is widely used, the ideal method for the administration of filgrastim has not been determined. Therefore, we compared the efficacy
Autor:
Akihiko Matsumoto, Hideaki Oda, Mineo Kurokawa, Fumio Nakahara, Seishi Ogawa, Hisamaru Hirai, Tsuyoshi Takahashi, Kyoko Haraguchi, Shigeru Chiba
Publikováno v:
Leukemia & Lymphoma. 47:2218-2223
Invariant natural killer T (iNKT) cells are thought to regulate anti-tumor immunity. Human iNKT (i.e. Valpha24+ NKT) cells have been reported to recognize CD1d on target cells and show cytotoxicity directly on the target cells in vitro. However, the
Autor:
Masami Bessho, Kazuma Ohyashiki, Hideaki Mizoguchi, Takashi Uchiyama, Tomomitsu Hotta, Tomoki Naoe, Yoshikazu Ito, Hisamaru Hirai, Kinuko Mitani, Mitsuhiro Omine, Seishi Ogawa
Publikováno v:
International Journal of Hematology. 82:236-242
To standardize a rational therapeutic strategy of chemotherapy using the International Prognostic Scoring System (IPSS), we retrospectively analyzed 292 high-risk myelodysplastic syndrome (MDS) patients in 20 hospitals in Japan. Results of multivaria
Autor:
Takahiro Suzuki, Yasuyuki Morishita, Toshiki Saito, Kinuko Mitani, Sachiko Seo, Tetsuya Yamagata, Go Yamamoto, Takashi Asai, Shigeru Chiba, Seishi Ogawa, Mineo Kurokawa, Tetsuya Nakamoto, Ryuichi Sakai, Masahito Kawazu, Hisamaru Hirai, Motoshi Ichikawa
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
The lymphocyte-specific Cas family protein Cas-L (Crk-associated substrate lymphocyte type) has been implicated to function in lymphocyte movement, mediated mainly by integrin signaling. However, its physiological role is poorly understood. In this s
Autor:
Masahiko Kusumoto, Yoshinobu Kanda, Ukihide Tateishi, Rie Kojima, Shigesaburo Miyakoshi, Shigeru Chiba, Naoko Murashige, Eiji Kusumi, Yoichi Takaue, Shinichiro Mori, Yuji Tanaka, Hisamaru Hirai, Miwa Sakai, Hisashi Sakamaki, Masahiro Kami, Shuichi Taniguchi, Yasuhito Nannya
Publikováno v:
Biology of Blood and Marrow Transplantation. 11:506-511
Computed tomography (CT) is a powerful diagnostic tool for invasive aspergillosis (IA) after allogeneic stem cell transplantation (allo-SCT); however, little information is available concerning CT findings of late IA after allo-SCT. To characterize C
Autor:
Koji Izutsu, Shiho Tsujino, Akira Hangaishi, Koji Kandabashi, Seishi Ogawa, Masahiro Nakagawa, Mamiko Sakata-Yanagimoto, Kumi Oshima, Yoshinobu Kanda, Shigeru Chiba, Yuki Asano-Mori, Hisamaru Hirai, Toru Motokura
Publikováno v:
Transplantation. 79:1351-1357
Background Alemtuzumab, a humanized monoclonal antibody directed against human CD52, has a strong lympholytic effect. This study evaluates the safety of unmanipulated peripheral blood stem-cell transplantation from two or three loci-mismatched relate
Autor:
Kumi Oshima, Shigeyuki Kojima, Yoshinobu Kanda, Masaaki Akahane, Shigeru Chiba, Hiroyuki Isayama, Yuki Asano-Mori, Toru Motokura, Hisamaru Hirai, Minoru Tada, Yutaka Komatsu, Seishi Ogawa, Kuni Ohtomo, Masao Omata
Publikováno v:
Transplantation. 79:821-827
Background. The prognosis of advanced pancreatic cancer is extremely poor and therefore a novel treatment strategy is desired. The authors thus started a prospective study of allogeneic reduced-intensity hematopoietic stem cell transplantation (RIST)
Autor:
H. Yamamoto, Kunikazu Tsuji, Hisamaru Hirai, Kazuhisa Nakashima, Akira Nifuji, Mikihiko Morinobu, Zhong Jian Shen, Tetsuya Nakamoto, Kazunori Hino, Masaki Noda
Publikováno v:
The Journal of Experimental Medicine
Osteoporosis is a major health problem; however, the mechanisms regulating adult bone mass are poorly understood. Cas-interacting zinc finger protein (CIZ) is a nucleocytoplasmic shuttling protein that localizes at cell adhesion plaques that form whe