Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hisako Nakayama"'
Autor:
Hisako Nakayama, Taisuke Miyazaki, Manabu Abe, Maya Yamazaki, Yoshinobu Kawamura, Myeongjeong Choo, Kohtarou Konno, Shinya Kawata, Naofumi Uesaka, Kouichi Hashimoto, Mariko Miyata, Kenji Sakimura, Masahiko Watanabe, Masanobu Kano
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Developmental synapse elimination is crucial for shaping mature neural circuits. In the neonatal mouse cerebellum, Purkinje cells (PCs) receive excitatory synaptic inputs from multiple climbing fibers (CFs) and synapses from all but one CF a
Externí odkaz:
https://doaj.org/article/e80e973d0ab14075a84e8ce4a8bc2a88
Autor:
Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are associated with cancer. Here we show that an underlying mechanism for this phenotype in the
Externí odkaz:
https://doaj.org/article/59ba976a12834ee782df85c5cc6333ba
Autor:
Teruyoshi Hirayama, Yuuki Kadooka, Etsuko Tarusawa, Sei Saitoh, Hisako Nakayama, Natsumi Hoshino, Soichiro Nakama, Takahiro Fukuishi, Yudai Kawanishi, Hiroki Umeshima, Koichi Tomita, Yumiko Yoshimura, Niels Galjart, Kouichi Hashimoto, Nobuhiko Ohno, Takeshi Yagi
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract CCCTC-binding factor (CTCF) has a key role in higher-order chromatin architecture that is important for establishing and maintaining cell identity by controlling gene expression. In the mature cerebellum, CTCF is highly expressed in Purkinje
Externí odkaz:
https://doaj.org/article/a72517b6649347dfb51706d49c79da9c
Autor:
Esther Suk King Lai, Hisako Nakayama, Taisuke Miyazaki, Takanobu Nakazawa, Katsuhiko Tabuchi, Kouichi Hashimoto, Masahiko Watanabe, Masanobu Kano
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
Neuroligin is a postsynaptic cell-adhesion molecule that is involved in synapse formation and maturation by interacting with presynaptic neurexin. Mutations in neuroligin genes, including the arginine to cystein substitution at the 451st amino acid r
Externí odkaz:
https://doaj.org/article/141b7f26fcbf4eb4b023071721aa8f6d
Autor:
Nobuyuki Murabayashi, Takako Akahoshi, Risa Ishimine, Nobuko Saji, Chiyomi Takeda, Hisako Nakayama, Megumi Noro, Hiroko Fujimoto, Megumi Misaki, Keiko Miyamoto, Yukiko Yamada, Itaru Kohya, Mayu Kondo, Haruyasu Yamaguchi, Daisuke Sasaki, Yasuji Murai
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra, Vol 9, Iss 1, Pp 87-99 (2019)
Background: Music therapy (MT) may exert beneficial preventive effects in frail elderly individuals in psychophysiological health. Objectives: One hundred and fifteen frail elderly individuals (65–89 years old) participated. Methods: Subjects were
Externí odkaz:
https://doaj.org/article/cbdbfdd9d9b547fe83773d9b668507d0
Autor:
Hisako Nakayama, Manabu Abe, Chie Morimoto, Tadatsune Iida, Shigeo Okabe, Kenji Sakimura, Kouichi Hashimoto
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
In the mammalian cerebellum, surplus synapses between climbing fibers (CF) and Purkinje cells (PC) are developmentally pruned. Here, Nakayama and colleagues show that ablation of microglia impairs pruning of CF-PC synapses because of dysfunction of G
Externí odkaz:
https://doaj.org/article/f7b66f5d077b4f0ea3babcd030736b66
Autor:
Yoshiko Matsumoto-Makidono, Hisako Nakayama, Miwako Yamasaki, Taisuke Miyazaki, Kazuto Kobayashi, Masahiko Watanabe, Masanobu Kano, Kenji Sakimura, Kouichi Hashimoto
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 994-1004 (2016)
Some neurons have the ability to enhance output voltage to input current with a preferred frequency, which is called resonance. Resonance is thought to be a basis for membrane potential oscillation. Although ion channels responsible for resonance hav
Externí odkaz:
https://doaj.org/article/f1907a26d5ad4e338b5a85e13de245e1
Autor:
Kouichi Hashimoto, Yosuke Yamawaki, Kenji Yamaoka, Takayuki Yoshida, Kana Okada, Wanqin Tan, Miwako Yamasaki, Yoshiko Matsumoto-Makidono, Reika Kubo, Hisako Nakayama, Tsutomu Kataoka, Takashi Kanematsu, Masahiko Watanabe, Yasumasa Okamoto, Shigeru Morinobu, Hidenori Aizawa, Shigeto Yamawaki
Publikováno v:
Brain Communications
Animals suffering from uncontrollable stress sometimes show low effort to escape stress (learned helplessness). Changes in serotonin (5-hydroxytryptamine) signalling are thought to underlie this behaviour. Although the release of 5-hydroxytryptamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf501e1446e828138780823a6331dcc9
https://doi.org/10.1093/braincomms/fcab285
https://doi.org/10.1093/braincomms/fcab285
Autor:
Risa Ishimine, Mayu Kondo, Hisako Nakayama, Yukiko Yamada, Daisuke Sasaki, Haruyasu Yamaguchi, Itaru Kohya, Yasuji Murai, Keiko Miyamoto, Nobuko Saji, Megumi Noro, Takako Akahoshi, Megumi Misaki, Hiroko Fujimoto, Chiyomi Takeda, Nobuyuki Murabayashi
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra, Vol 9, Iss 1, Pp 87-99 (2019)
Background: Music therapy (MT) may exert beneficial preventive effects in frail elderly individuals in psychophysiological health. Objectives: One hundred and fifteen frail elderly individuals (65–89 years old) participated. Methods: Subjects were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0805387270b2520a761683f6b62704
https://doi.org/10.1159/000496456
https://doi.org/10.1159/000496456
Autor:
Atsu Aiba, Hiroyuki Sakagami, Yusuke Sakai, Hidetoshi Kassai, Tatsuya Maeda, Masahiro Fukaya, Kouichi Hashimoto, Hisako Nakayama, Kazuki Nakao, Masanobu Kano
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolism. The importance of mTORC1 signaling in neuronal development and functions has been highlighted by its strong relationship with many neurological and neuropsychiatric d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8a4b36979b214d63371b86314fa586
https://doi.org/10.1038/s41598-019-38730-4
https://doi.org/10.1038/s41598-019-38730-4