Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hisako Akiyama"'
Autor:
Masanori Sawamura, Kiyoshi Tachikawa, Rie Hikawa, Hisako Akiyama, Seiji Kaji, Ken Yasuda, Angel I. Leu, Hyojung Hong, Rajesh Mukthavaram, Pad Chivukula, Hodaka Yamakado, Yoshio Hirabayashi, Ryosuke Takahashi, Shu-ichi Matsuzawa
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102380- (2024)
Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used viral vectors are not efficient in transforming oligodendrocy
Externí odkaz:
https://doaj.org/article/a690f55095224122b98cf44013d30ce2
Autor:
Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Sawamura Masanori, Yosuke Taruno, Hodaka Yamakado, Shu-ichi Matsuzawa, Shunichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Homozygous mutations in the lysosomal glucocerebrosidase gene, GBA1, cause Gaucher’s disease (GD), while heterozygous mutations in GBA1 are a strong risk factor for Parkinson’s disease (PD), whose pathological hallmark is intraneuronal
Externí odkaz:
https://doaj.org/article/4dcda80e219b4d179a2bdf0bf1201e92
Autor:
Lindsey T. Lelieveld, Mina Mirzaian, Chi-Lin Kuo, Marta Artola, Maria J. Ferraz, Remco E.A. Peter, Hisako Akiyama, Peter Greimel, Richard J.B.H.N. van den Berg, Herman S. Overkleeft, Rolf G. Boot, Annemarie H. Meijer, Johannes M.F.G. Aerts
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1851-1867 (2019)
μ-glucosidases [GBA1 (glucocerebrosidase) and GBA2] are ubiquitous essential enzymes. Lysosomal GBA1 and cytosol-facing GBA2 degrade glucosylceramide (GlcCer); GBA1 deficiency causes Gaucher disease, a lysosomal storage disorder characterized by lys
Externí odkaz:
https://doaj.org/article/05ce0c35bb594489bd17fa37e18c9942
Autor:
Hisako Akiyama, Kazuki Nakajima, Yoshiyuki Itoh, Tomoko Sayano, Yoko Ohashi, Yoshiki Yamaguchi, Peter Greimel, Yoshio Hirabayashi
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 2061-2072 (2016)
To date, sterylglucosides have been reported to be present in various fungi, plants, and animals. In bacteria, such as Helicobacter pylori, proton NMR spectral analysis of isolated 1-O-cholesteryl-β-d-glucopyranoside (GlcChol) demonstrated the prese
Externí odkaz:
https://doaj.org/article/40d0c6e1f2444cbda84027b8dfcb831c
Autor:
AndréR.A. Marques, Mina Mirzaian, Hisako Akiyama, Patrick Wisse, Maria J. Ferraz, Paulo Gaspar, Karen Ghauharali-van der Vlugt, Rianne Meijer, Pilar Giraldo, Pilar Alfonso, Pilar Irún, Maria Dahl, Stefan Karlsson, Elena V. Pavlova, Timothy M. Cox, Saskia Scheij, Marri Verhoek, Roelof Ottenhoff, CindyP.A.A. van Roomen, Navraj S. Pannu, Marco van Eijk, Nick Dekker, Rolf G. Boot, Herman S. Overkleeft, Edward Blommaart, Yoshio Hirabayashi, Johannes M. Aerts
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 3, Pp 451-463 (2016)
The membrane lipid glucosylceramide (GlcCer) is continuously formed and degraded. Cells express two GlcCer-degrading β-glucosidases, glucocerebrosidase (GBA) and GBA2, located in and outside the lysosome, respectively. Here we demonstrate that throu
Externí odkaz:
https://doaj.org/article/57f08df9b338494281ce0b82ea7d752a
Autor:
Tatsuro Mutoh, Yoshiki Niimi, Shinji Ito, Hisako Akiyama, Ryoichi Shiroki, Yoshio Hirabayashi, Kiyotaka Hoshinaga
Publikováno v:
Biochemical and Biophysical Research Communications. 639:84-90
Idiopathic normal pressure hydrocephalus usually exhibits triad of symptoms including gait disturbance, urinary incontinence, and dementia with ventriculomegaly. Currently, its pathogenesis remains to be fully elucidated. To provide a better understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f96f07696a740bb57cbbc96bdae0e3
https://doi.org/10.1016/j.bbrc.2022.11.091
https://doi.org/10.1016/j.bbrc.2022.11.091
Autor:
Takahiro Ikazaki, Eri Ishikawa, Hiroto Tamashima, Hisako Akiyama, Yusuke Kimuro, Makoto Yoritate, Hiroaki Matoba, Akihiro Imamura, Hideharu Ishida, Sho Yamasaki, Go Hirai
Publikováno v:
Angewandte Chemie. 135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1ed15ac3d7f22521645544492325f3
https://doi.org/10.1002/ange.202302569
https://doi.org/10.1002/ange.202302569
Autor:
Yoshio Hirabayashi, Ryoichi Shiroki, Hirohisa Watanabe, Tatsuro Mutoh, Yasuaki Mizutani, Hisako Akiyama, Yoshiki Niimi, Kiyotaka Hoshinaga
Publikováno v:
Journal of Parkinson's Disease. 11:221-232
Background: As mutations in glucocerebrosidase 1 (GBA1) are a major risk factor for Parkinson’s disease (PD), decreased GBA1 activity might play an important role in the pathogenesis of the disease. However, there are currently no reports on glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a98c2c413d8a263b82bfb44e53e190e
https://doi.org/10.3233/jpd-202310
https://doi.org/10.3233/jpd-202310
Autor:
Tatsuro Mutoh, Hisako Akiyama, Hiroyuki Kamiguchi, Yasuaki Mizutani, Toshiyuki Yamaji, Yoshio Hirabayashi, Yoshiki Niimi, Mitsuko Ide
Publikováno v:
Biochemical and Biophysical Research Communications. 536:73-79
Cerebrospinal fluid (CSF) contains glycosphingolipids, including lactosylceramide (LacCer, Galβ(1,4)Glcβ-ceramide). LacCer and its structural isomer, galabiosylceramide (Gb2, Galα(1,4)Galβ-ceramide), are classified as ceramide dihexosides (CDH).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cd40b7fdd131989f1f4194f330aad0
https://doi.org/10.1016/j.bbrc.2020.12.051
https://doi.org/10.1016/j.bbrc.2020.12.051
Autor:
Laxmi Kumar Parajuli, Norihito Uemura, Yusuke Hatanaka, Masaki Tanaka, Hisako Akiyama, Kousaku Ohno, Masato Koike, Yoshio Hirabayashi, Katsumi Higaki, Ryosuke Takahashi, Hodaka Yamakado, Masashi Ikuno, Junko Hara, Katsutoshi Taguchi
Publikováno v:
Human Molecular Genetics. 28:1894-1904
Parkinson's disease (PD) is characterized by dopaminergic (DA) cell loss and the accumulation of pathological alpha synuclein (asyn), but its precise pathomechanism remains unclear, and no appropriate animal model has yet been established. Recent stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a034154215b484b2d7204c1a9bc58db5
https://doi.org/10.1093/hmg/ddz030
https://doi.org/10.1093/hmg/ddz030