Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Hisakata Yamada"'
Autor:
Kazuhiro Kai, Hisakata Yamada, Ryosuke Tsurui, Koji Sakuraba, Kenjiro Fujimura, Shinya Kawahara, Yukio Akasaki, Hidetoshi Tsushima, Toshifumi Fujiwara, Daisuke Hara, Jun-ichi Fukushi, Shinichiro Sawa, Yasuharu Nakashima
Publikováno v:
Immunological Medicine, Vol 47, Iss 2, Pp 58-67 (2024)
AbstractSynovial tissue-resident macrophages (STRMs) maintain normal joint homeostasis in a steady state. However, it is unclear whether STRMs still play homeostatic roles or change the functions in the joint of rheumatoid arthritis (RA), where infil
Externí odkaz:
https://doaj.org/article/dd6af40ea5434630a66be9d973fa9ae0
Autor:
Takahiko Horiuchi, Hiroaki Niiro, Koichi Akashi, Nobuyuki Ono, Yasutaka Kimoto, Hiroki Mitoma, Yasuharu Nakashima, Hisakata Yamada, Masakazu Kondo, Fumiaki Sagawa, Masahiro Ayano, Yojiro Arinobu
Publikováno v:
RMD Open, Vol 10, Iss 1 (2024)
Objectives Understanding interpatient variation in CD4+T-cell responses is the bases for understanding the pathogenesis and management of rheumatoid arthritis (RA). We examined immune responses to SARS-CoV-2 vaccine in a cohort of patients with RA an
Externí odkaz:
https://doaj.org/article/26c8a987858b4d0899f2f15ee15dbd1d
Autor:
Toshifumi Fujiwara, Masakazu Kondo, Hisakata Yamada, Akihisa Haraguchi, Kenjiro Fujimura, Koji Sakuraba, Satoshi Kamura, Jun-ichi Fukushi, Hisaaki Miyahara, Yasushi Inoue, Tomomi Tsuru, Toshihide Shuto, Seiji Yoshizawa, Eiichi Suematsu, Tomoya Miyamura, Masahiro Ayano, Hiroki Mitoma, Yojiro Arinobu, Hiroaki Niiro, Masanobu Ohishi, Akie Hirata, Shoji Tokunaga, Atsushi Takada, Daisuke Hara, Hidetoshi Tsushima, Yukio Akasaki, Satoshi Ikemura, Takuya Sueishi, Masakazu Toya, Takahide Sakuragi, Tomoko Tsutsui, Kazuhiro Kai, Shinkichi Arisumi, Yasuharu Nakashima
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-15 (2022)
Abstract Background To further improve rheumatoid arthritis (RA) treatment, it is necessary to understand each RA patient’s satisfaction and to identify the factors affecting their satisfaction. Despite the rise in medical costs for RA, little is k
Externí odkaz:
https://doaj.org/article/5da7eb72e7764e788a48b71d8a27b07d
Autor:
Hisakata Yamada
Publikováno v:
Immunological Medicine, Vol 45, Iss 1, Pp 1-11 (2022)
Adaptive immunity plays central roles in the pathogenesis of rheumatoid arthritis (RA), as it is regarded as an autoimmune disease. Clinical investigations revealed infiltrations of B cells in the synovium, especially those with ectopic lymphoid neog
Externí odkaz:
https://doaj.org/article/8ac35ff764e74ffea3cc097fd3052b92
Autor:
Masakazu Toya, Yukio Akasaki, Takuya Sueishi, Ichiro Kurakazu, Masanari Kuwahara, Taisuke Uchida, Tomoaki Tsutsui, Hidetoshi Tsushima, Hisakata Yamada, Martin K. Lotz, Yasuharu Nakashima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract G protein-coupled receptor kinase 5 (GRK5) regulates inflammatory responses via the nuclear factor-kappa B (NF-κB) pathway. This study investigated the functional involvement of GRK5 in the pathogenesis of inflammatory arthritis. Immunohist
Externí odkaz:
https://doaj.org/article/2638c7ea22824548af6160da54e5d45a
Autor:
Hisakata Yamada
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 6930 (2023)
Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting systemic synovial tissues, leading to the destruction of multiple joints. Its etiology is still unknown, but T-cell-mediated autoimmunity has been thought to play critical roles,
Externí odkaz:
https://doaj.org/article/44ad3c6e636f4f2795744c42f7632158
Autor:
Hisakata Yamada, Tomomi Tsuru, Takeshi Otsuka, Masayuki Maekawa, Hiroshi Harada, Takaaki Fukuda, Hiroshi Tsukamoto, Akira Maeyama, Shigeru Yoshizawa, Ken Wada, Yasuharu Nakashima, Eisuke Shono, Seiji Yoshizawa, Hiroshi Jojima, Masakazu Kondo
Publikováno v:
Immunological Medicine, Vol 43, Iss 2, Pp 87-91 (2020)
Abatacept may exert its clinical effect on rheumatoid arthritis (RA) by suppressing anti-cyclic citrullinated peptide (CCP) antibody production. This study was undertaken to test this hypothesis by examining the changes of disease activity of RA and
Externí odkaz:
https://doaj.org/article/1555dbb760624871b88689878032cfb0
Autor:
Ayako Takaki-Kuwahara, Yojiro Arinobu, Kohta Miyawaki, Hisakata Yamada, Hirofumi Tsuzuki, Kensuke Irino, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Hiroshi Tsukamoto, Takahiko Horiuchi, Hiroaki Niiro, Koichi Akashi
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-9 (2019)
Abstract Background Recent studies show that innate lymphoid cells (ILCs) contribute to the development of chronic inflammation and autoimmune disease. In this study, we assessed the ILC function in the development of rheumatoid arthritis (RA). Metho
Externí odkaz:
https://doaj.org/article/4bf8064b5623475e877e0314900a67f7
Autor:
Kazuhiko Higashioka, Motoki Yoshimura, Takahide Sakuragi, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Takahiko Horiuchi, Koichi Akashi, Hiroaki Niiro
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundRheumatoid arthritis (RA) is a prototypical autoantibody-driven autoimmune disease in which T-B interactions play a critical role. Recent comprehensive analysis suggests that PD-1+CD8+ T cells as well as two distinct IL-21-producing PD-1+CD
Externí odkaz:
https://doaj.org/article/092767c3b62f4d9d9c7fd77fa9a725f3
Autor:
Bruno Raposo, Patrick Merky, Christina Lundqvist, Hisakata Yamada, Vilma Urbonaviciute, Colin Niaudet, Johan Viljanen, Jan Kihlberg, Bruno Kyewski, Olov Ekwall, Rikard Holmdahl, Johan Bäcklund
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifica
Externí odkaz:
https://doaj.org/article/e3bc31ec183743a0819cb2d858e9e59c