Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hisaharu Yamada"'
Autor:
Frank D. Sistare, Takanori Ikeda, Shigeru Hisada, Hisaharu Yamada, Kenji Inoue, Kenjiro Tsubota
Publikováno v:
Journal of Toxicologic Pathology. 35:53-73
The pharmacokinetic endpoint of a 25-fold increase in human exposure is one of the specified criteria for high-dose selection for 2-year carcinogenicity studies in rodents according to ICH S1C(R2). However, this criterion is not universally accepted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9659600d7a670d10a8a26b7394849ef
https://doi.org/10.1293/tox.2021-0031
https://doi.org/10.1293/tox.2021-0031
Autor:
Kohei, Kikkawa, Hisaharu, Yamada
Publikováno v:
Folia Pharmacologica Japonica. 158:2-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a723e631f1712ca93b4f8ed12fdbe961
https://doi.org/10.1254/fpj.22128
https://doi.org/10.1254/fpj.22128
Autor:
Hisaharu, Yamada, Kohei, Kikkawa
Publikováno v:
Folia Pharmacologica Japonica. 157:248-248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a2a472bccea7e16c3821b7915add3b
https://doi.org/10.1254/fpj.22023
https://doi.org/10.1254/fpj.22023
Publikováno v:
The Journal of Toxicological Sciences. 42:615-627
Urinary biomarkers have been used widely in preclinical toxicity studies to detect dysfunctions and injuries of the kidney caused by drugs under development. While they have been well studied for evaluating nephrotoxicity, knowledge of sex difference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c042f41820b9d963cac23f504865159b
https://doi.org/10.2131/jts.42.615
https://doi.org/10.2131/jts.42.615
Autor:
Takashi Matsuda, Chisa Wada, Naohisa Tsutsui, Shyh-Yuh Liou, Shigeo Kamitsuji, Kenkichi Sugiura, Yusuke Kuwahara, Naoyuki Kamatani, Katsuki Tsuritani, Koichi Nishimura, Seiko Endo, Tomoko Kubota, Masatoshi Masuda, Woosung Yang, Tsutomu Fujiwara, Shinji Miyoshi, Akira Shinagawa, Kenji Watanabe, Wataru Uchida, Yuki Sugaya, Kinya Okada, Koichi Hasegawa, Taiji Sawamoto, Haretsugu Hishigaki, Hisaharu Yamada, Kazuyuki Nakazono, Koji Suematsu
Publikováno v:
Journal of Human Genetics. 60:319-326
Japan Pharmacogenomics Data Science Consortium (JPDSC) has assembled a database for conducting pharmacogenomics (PGx) studies in Japanese subjects. The database contains the genotypes of 2.5 million single-nucleotide polymorphisms (SNPs) and 5 human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0472eac6c47707bbc49585ec057a0d20
https://doi.org/10.1038/jhg.2015.23
https://doi.org/10.1038/jhg.2015.23
Autor:
Satoshi Tsuji, Kazufumi Kawasako, Kenta Matsue, Hisaharu Yamada, Emi Endo, Hiromi Maruyama, Yumi Wako, Yosuke Ogiwara, Junko Tawara, Kumiko Watanabe, Mihoko Sugiura
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :111-116
The repeated-dose liver micronucleus assay has the potential to detect liver carcinogens and could be integrated into general toxicological studies. To assess the performance of this assay, kojic acid was tested in 14-day and 28-day liver micronucleu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b546fb0f8039c61e7806736638d474d5
https://doi.org/10.1016/j.mrgentox.2015.01.004
https://doi.org/10.1016/j.mrgentox.2015.01.004
Autor:
Akiko Ikeda, Hisaharu Yamada
Publikováno v:
Folia Pharmacologica Japonica. 133:73-77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b785b32257f0c2d8e79ed3c499cc2d6e
https://doi.org/10.1254/fpj.133.73
https://doi.org/10.1254/fpj.133.73
Autor:
Hisaharu Yamada
Publikováno v:
Folia Pharmacologica Japonica. 133:154-157
腎臓は，組織の“不均一性”が高く，薬物により腎臓のさまざまな部位が障害される．障害部位の特定を含めた腎毒性の評価は，ラットを用いた一般毒性試験においても検査項目を充実
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b8924c2bb8af37807633db85923c8c
https://doi.org/10.1254/fpj.133.154
https://doi.org/10.1254/fpj.133.154
Autor:
Yoshinori Sekiguchi, Shigeyuki Chaki, Graeme Semple, William Thomsen, Junichi Yamaguchi, Thuy-Anh Tran, Hisaharu Yamada
Publikováno v:
CNS Drug Reviews. 11:341-352
Melanin‐concentrating hormone (MCH) has been implicated in a variety of physiological events. Recent studies clearly suggest that MCH plays an important role in the regulation of stress and emotion. To date, two receptor subtypes of MCH (MCH1R and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cd838e5eca7e81944252a7126f07c4
https://doi.org/10.1111/j.1527-3458.2005.tb00052.x
https://doi.org/10.1111/j.1527-3458.2005.tb00052.x
Publikováno v:
Folia Pharmacologica Japonica. 127:473-480
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::093472ea7e939661d93e031a1515fd20
https://doi.org/10.1254/fpj.127.473
https://doi.org/10.1254/fpj.127.473