Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hisafumi Okabe"'
Autor:
Rob Hooft van Huijsduijnen, Somei Kojima, Dee Carter, Hisafumi Okabe, Akihide Sato, Wataru Akahata, Timothy N C Wells, Kei Katsuno
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007860 (2020)
In the past two decades there has been a significant expansion in the number of new therapeutic monoclonal antibodies (mAbs) that are approved by regulators. The discovery of these new medicines has been driven primarily by new approaches in inflamma
Externí odkaz:
https://doaj.org/article/f943fdcc8ea44d97886eddaabf3dcef9
Autor:
Ruth Duncan, Iwao Ojima, Dario Neri, Nobuo Shimma, Hisafumi Okabe, Hideo Ishitsuka, Hans Peter Märki
Publikováno v:
CHIMIA, Vol 62, Iss 11 (2008)
Specific targeting of drugs to their respective target organs or tissues is challenging. Substantial research efforts have been undertaken in the recent past to develop target specific drugs or drug conjugates. Such concepts are most relevant in rath
Externí odkaz:
https://doaj.org/article/91a053b54cb141e3959ea5317a12a247
Publikováno v:
Experimental Hematology. 34:320-329
Objective Establishment of a stable umbilical cord blood CD34 + (UCB CD34 + ) cell culture system and identification of the cells in the cobblestone area differentiated from UCB CD34 + long-term culture cells. Materials and Methods Human UCB CD34 + c
Autor:
Hisafumi Okabe, Shuji Ozaki, Yumiko Azuma, Tetsuro Orita, Yuichi Hirata, Masayuki Tsuchiya, Yasuko Kinoshita, Naoki Kimura, Masamichi Sugimoto, Toshio Matsumoto, Takahiro Ishiguro, Shigeto Kawai, Masahiro Abe
Publikováno v:
Biochemical and Biophysical Research Communications. 325:1201-1209
A mouse monoclonal antibody (2D7 mAb), which specifically bound to the alpha2 domain of HLA class I, rapidly induces cell aggregation accompanied by weak cytotoxicity against ARH-77 cells, suggesting that 2D7 mAb had a potential for agonist antibody.
Autor:
Kenji Hamada, Hidenori Sasaki, Ichiro Nishikata, Hirohito Tsubouchi, Takeshi Fukami, Tomonori Hidaka, Ena Akamatsu, Akihiko Okayama, Yoko Kubuki, Hisafumi Okabe, Yoshinori Murakami, Kazuhiro Morishita, Toshiyuki Shiraga
Publikováno v:
Blood. 105:1204-1213
Adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type 1 (HTLV-1) infection, occurs in 2% to 4% of the HTLV-1 carriers with a long latent period, suggesting that additional alterations participate in the development of ATL. To charact
Autor:
Yoshihide Otani, Hironobu Nakayama, Tetsuro Kubota, Masahiko Watanabe, Kazuhiro Suganuma, Yoshiro Saikawa, Masaki Kitajima, Hisafumi Okabe, Hirotoshi Hasegawa, Toshiharu Furukawa, Sadanori Abe, Koichiro Kumai
Publikováno v:
Cancer Science. 94:355-359
To identify chemoresistance-related genes of gastric cancer, we utilized cDNA microarray technology. Thirty-five gastric cancer specimens surgically resected at our institute between 1998 and 1999 were studied for quantification of expression of 6300
Autor:
Toshiyuki Mio, Hisafumi Okabe
Publikováno v:
Handbook of Glycosyltransferases and Related Genes ISBN: 9784431542391
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aeb96e6a08a76a2b467af8b6c2a407c
https://doi.org/10.1007/978-4-431-54240-7_153
https://doi.org/10.1007/978-4-431-54240-7_153
Autor:
Toshiyuki Mio, Hisafumi Okabe
Publikováno v:
Handbook of Glycosyltransferases and Related Genes ISBN: 9784431542391
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b5af25221f654090215187ad961930c
https://doi.org/10.1007/978-4-431-54240-7_152
https://doi.org/10.1007/978-4-431-54240-7_152
Autor:
Ryoichi Saitoh, Takaaki Miura, Takeshi Murata, Yasuaki Matsubara, Christine Lukacs, Eisaku Mizuguchi, Nobuo Shimma, Yasunori Chugai Seiyaku Kabushiki Kaisha Kohchi, Charles Belunis, Hisafumi Okabe, Yoshiaki Isshiki, Masanori Miwa, Verena Schück, Kohsuke Asoh, Kazuo Hattori, Hitoshi Iikura, Shinji Chugai Seiyaku Kabushiki Kaisha Tsujii, Naoaki Murao, Masami Kohchi, Cheryl Janson, Yasushi Yoshimura, Satoshi Aida
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
The MAP kinase pathway is one of the most important pathways involved in cell proliferation and differentiation, and its components are promising targets for antitumor drugs. Design and synthesis of a novel MEK inhibitor, based on the 3D-structural i
Autor:
Mika Endo, Kazuko Kobayashi, Chikako Murasaki, Kenji Morikami, Kotaro Ogawa, Nobuo Shimma, Eitaro Nanba, Yoko Miyazaki, Isao Imperial Higashihak Umeda, Kiyoshi Yoshinari, Hiroshi Fukuda, Masako Ura, Satoshi Niizuma, Hitomi Suda, Takeshi Murata, Hisafumi Okabe, Tsuyoshi Takasuka, Jun Ohwada, Sawako Ozawa, Akira Kawashima, Hiromi Tanimura, Kounosuke Nakano, Masami Kohchi, Masao Tsukazaki
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(7)
Novel hexacyclic camptothecin analogs containing cyclic amidine, urea, or thiourea moiety were designed and synthesized based on the proposed 3D-structure of the topoisomerase I (Topo I)/DNA/camptothecin ternary complex. The analogs were prepared fro