Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hisae Niki"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 119, Iss 3, Pp 243-250 (2012)
To clarify the involvement of 5-hydroxytryptamine (5-HT) in promotion of thrombogenesis in diabetes, we examined the inhibitory effect of sarpogrelate, a 5-HT2A receptor antagonist, on thrombus formation in diabetic rats. In streptozotocin-induced di
Externí odkaz:
https://doaj.org/article/254b979b6dfe47fb8d60797d095402ec
Autor:
Toshiaki Tagawa, Yoko Hirakawa, Kazuhiro Nagaike, Katsuhiko Nohga, Saiko Hosokawa, Hisae Niki, Norihiko Ito
Publikováno v:
Hybridoma and Hybridomics. 23:109-120
To establish human monoclonal antibodies suitable for targeting chemotherapy, we prepared a panel of human-mouse hybridomas, using mouse myelomas and lymphocytes of regional lymph nodes excised from cancer patients, and selected antibodies on the bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4ac268161db0b47d95897a0a612511
https://doi.org/10.1089/153685904774129711
https://doi.org/10.1089/153685904774129711
Publikováno v:
British Journal of Cancer
We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e60d49d70d09945cdf8e3f6a9835cd6
https://doi.org/10.1038/sj.bjc.6601341
https://doi.org/10.1038/sj.bjc.6601341
Publikováno v:
European Journal of Pharmacology. 320:193-200
In the recurrence of allergic inflammation in a rat air pouch model, pouch fluid volume, prostaglandin E2 concentration in the pouch fluid, leukocyte infiltration into the pouch fluid, and granulation tissue weight were markedly increased by the anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1fffdcd5e05dcb559dcdc7b549cc08
https://doi.org/10.1016/s0014-2999(96)00898-9
https://doi.org/10.1016/s0014-2999(96)00898-9
Publikováno v:
Journal of Pharmacological Sciences, Vol 119, Iss 3, Pp 243-250 (2012)
To clarify the involvement of 5-hydroxytryptamine (5-HT) in promotion of thrombogenesis in diabetes, we examined the inhibitory effect of sarpogrelate, a 5-HT2A receptor antagonist, on thrombus formation in diabetic rats. In streptozotocin-induced di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e538c63c56223300d3829ee1f0b189e
https://pubmed.ncbi.nlm.nih.gov/22785018
https://pubmed.ncbi.nlm.nih.gov/22785018
Autor:
Hisae Niki, Toshiaki Tagawa, Tetsuya Hamaguchi, Yasuhiro Matsumura, Tadao Kakizoe, Yukihiro Nakanishi, Kei Muro, Kuniaki Shirao, Yasuhiro Shimada, Saiko Hosokawa, Yasuhide Yamada
Publikováno v:
Cancer science. 95(7)
MCC-465 is an immunoliposome-encapsulated doxorubicin. The liposome is tagged with polyethylene glycol and the F(ab')2 of a monoclonal antibody named GAH, a human antibody obtained by the hybridoma technique. The epitope recognized by GAH is not well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e2af826425573daa5eb95efba3ff4c
https://pubmed.ncbi.nlm.nih.gov/15245599
https://pubmed.ncbi.nlm.nih.gov/15245599
Publikováno v:
Journal of immunological methods. 293(1-2)
Immunofluorostaining, a versatile tissue staining method, is used in biomedical research because of its clear contrast and precise quantification of positive signals. However, its application in clinical diagnosis has been limited. A major obstacle i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c437bc07d45e52ce2502e22c8fd9826
https://pubmed.ncbi.nlm.nih.gov/15541284
https://pubmed.ncbi.nlm.nih.gov/15541284
Publikováno v:
European journal of pharmacology. 344(2-3)
JTE-522, 4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide, is a selective inhibitor of cyclooxygenase-2 at the enzyme level (IC50 is 6.4×10−7 M for sheep cyclooxygenase-2, but it does not inhibit sheep cyclooxygenase-1 at concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d43870ab2509819a5335051dd559666
https://pubmed.ncbi.nlm.nih.gov/9600662
https://pubmed.ncbi.nlm.nih.gov/9600662
Publikováno v:
European journal of pharmacology. 338(2)
In RAW 264.7 cells, a murine macrophage cell line, treatment with lipopolysaccharide (1 to 10 ng/ml) stimulated production of nitric oxide (NO), which was inhibited by L-N(G)-monomethyl-L-arginine acetate, an inhibitor of NO synthase. Auranofin, an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ac4bfff8579fadc96cd8f88cd3d670
https://pubmed.ncbi.nlm.nih.gov/9455997
https://pubmed.ncbi.nlm.nih.gov/9455997
Autor:
Hisae Niki, Masateru Yamada, Kazuo Ohuchi, Masamichi Yamashita, Suetsugu Mue, Masako Watanabe-Kobayashi
Publikováno v:
European journal of pharmacology. 325(2-3)
Incubation of rat peritoneal macrophages in medium containing various concentrations of auranofin (1, 3 and 10 μM) increased prostaglandin E2 production at 4 h in a concentration-dependent manner, in accordance with the increase in the release of [3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794c0c2bba2456f154f81b449d104dde
https://pubmed.ncbi.nlm.nih.gov/9163569
https://pubmed.ncbi.nlm.nih.gov/9163569