Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Hisaaki Kawakatsu"'
Autor:
Richard C. Bates, David I. Bellovin, Courtney Brown, Elizabeth Maynard, Bingyan Wu, Hisaaki Kawakatsu, Dean Sheppard, Peter Oettgen, Arthur M. Mercurio
Publikováno v:
Journal of Clinical Investigation. 115:339-347
Autor:
Shelia M. Violette, Amha Atakilit, William Yang, Paul H. Weinreb, Diane R Leone, Kenneth Simon, Brian M. Dolinski, Yukako Yokota, Hisaaki Kawakatsu, Bradley R. Pearse, Dean Sheppard, Paul Rayhorn
Publikováno v:
Journal of Biological Chemistry. 279:17875-17887
We have generated a panel of potent, selective monoclonal antibodies that bind human and mouse alpha(v)beta(6) integrin with high affinity (up to 15 pm). A subset of these antibodies blocked the binding of alpha(v)beta(6) to the transforming growth f
Autor:
Yves Berthiaume, Jérémie Roux, George Su, Jean-Francois Pittet, Cecilia M. Canessa, André Dagenais, Xiaohui Fang, Hisaaki Kawakatsu, Marybeth Howard, Michael A. Matthay, James A. Frank, Dean Sheppard
Publikováno v:
Journal of Biological Chemistry. 278:43939-43950
Acute lung injury (ALI) is characterized by the flooding of the alveolar airspaces with protein-rich edema fluid and diffuse alveolar damage. We have previously reported that transforming growth factor-beta1 (TGF-beta1) is a critical mediator of ALI
Autor:
James Surapisitchat, Bradford C. Berk, Masashi Akaike, Jun Ichi Abe, Hisaaki Kawakatsu, Masanori Yoshizumi, Nicole Lerner-Marmarosh, Wenyi Che, Chen Yan, Bo Ding, Qunhua Huang
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:1775-1781
Objectives— Atherosclerosis preferentially occurs in areas of turbulent flow, whereas laminar flow is atheroprotective. Inflammatory cytokines have been shown to stimulate adhesion molecule expression in endothelial cells that may promote atheroscl
Autor:
Joshua Cottom, Stephen S. Palmer, Mary Hunzicker-Dunn, Evelyn T. Maizels, Daniel W. Carr, Lisa M. Salvador, Paul Dent, Scott Reierstad, Monika A. Davare, Johannes W. Hell, Young-Kyu Park, Hisaaki Kawakatsu, Masato Ogata
Publikováno v:
Journal of Biological Chemistry. 278:7167-7179
In this report we sought to elucidate the mechanism by which the follicle-stimulating hormone (FSH) receptor signals to promote activation of the p42/p44 extracellular signal-regulated protein kinases (ERKs) in granulosa cells. Results show that the
Autor:
Takao Sakai, Hisaaki Kawakatsu, Yasuhiro Ito, Tsutomu Takeda, Naoyuki Tani, Naomasa Kawaguchi, Shinzaburo Noguchi, Nariaki Matsuura
Publikováno v:
Breast Cancer Research and Treatment. 76:261-267
In order to investigate whether c-Src is involved in carcinogenesis and progression of breast carcinoma, we examined the expression of activated c-Src in tissue sections from surgically resected human breast specimens. First, we confirmed the specifi
Autor:
Qunhua Huang, Jun Ichi Abe, Yasuchika Takeishi, Hisaaki Kawakatsu, Richard A. Walsh, Bradford C. Berk, Brian D. Hoit, Jiing Dwan Lee, Wenyi Che
Publikováno v:
Cardiovascular Research. 53:131-137
Objective: A new member of the MAP kinase family, big MAP kinase-1 (BMK1), has been recently identified to promote cell growth and attenuate apoptosis. P90 ribosomal S6 kinase (p90RSK), one of the potentially important substrates of extracellular sig
Autor:
Stephanie Cambier, Lars Fjellbirkeland, Hisaaki Kawakatsu, Jody L. Baron, Dezhi Mu, Dean Sheppard, V. Courtney Broaddus, John S. Munger, Stephen L. Nishimura
Publikováno v:
The Journal of Cell Biology
Integrins, matrix metalloproteases (MMPs), and the cytokine TGF-beta have each been implicated in homeostatic cell behaviors such as cell growth and matrix remodeling. TGF-beta exists mainly in a latent state, and a major point of homeostatic control
Autor:
Hisaaki Kawakatsu, Richard A. Walsh, Jun Ichi Abe, Qunhua Huang, Michael Glassman, Earl G. Lawrence, Wenyi Che, Brian D. Hoit, Bradford C. Berk, Yasuchika Takeishi, Jiing Dwan Lee
Publikováno v:
Journal of Molecular and Cellular Cardiology. 33:1637-1648
Activation of members of the mitogen-activated protein (MAP) kinase family and their downstream effectors has been proposed to play a key role in the pathogenesis of cell survival, ischaemic preconditioning, cardiac hypertrophy and heart failure. Thi
Autor:
Christof R. Hauck, David D. Schlaepfer, Eduardo A. C. Almeida, Dusko Ilic, Hisaaki Kawakatsu, Caroline H. Damsky, Fang Jin, Qin Han
Publikováno v:
The Journal of Cell Biology
Most transformed cells have lost anchorage and serum dependence for growth and survival. Previously, we established that when serum is absent, fibronectin survival signals transduced by focal adhesion kinase (FAK), suppress p53-regulated apoptosis in