Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hisaaki Chaki"'
Autor:
Tetsuya Yamamoto, Kimiko Morimoto, Hisaaki Chaki, Shuichi Hirono, Akira Hashiramoto, Hirokazu Narita, Yukihiko Aikawa, Shunichi Shiozawa
Publikováno v:
Nature Biotechnology. 26:817-823
To inhibit arthritis upstream of inflammatory cytokine release and matrix metalloproteinase (MMP) action, we designed de novo a small-molecule inhibitor of c-Fos/activator protein-1 (AP-1) using three-dimensional (3D) pharmacophore modeling. This mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7feb853cafe48ebec6136235f15b473
https://doi.org/10.1038/nbt1412
https://doi.org/10.1038/nbt1412
Autor:
Yukihiko Aikawa, Tadakazu Takakura, Keiichi Tsuchida, Shuichi Hirono, Hisaaki Chaki, Hiroaki Gouda, Shunichi Shiozawa, Junichi Yokotani
Publikováno v:
Journal of Medicinal Chemistry. 47:4239-4246
The transcription factor activator protein-1 (AP-1) is an attractive target for the treatment of immunoinflammatory diseases, such as rheumatoid arthritis. Using the three-dimensional (3D) X-ray crystallographic structure of the DNA-bound basic regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9177f136e8a0c6d40b6a681a50afce
https://doi.org/10.1021/jm049890+
https://doi.org/10.1021/jm049890+
Autor:
Hisaaki Chaki, Yozo Todo, Hirokazu Narita, Tetsuo Yamafuji, Kazunori Kitamura, Masaru Tai, Hajime Morita, Mutsuko Maekawa, Naomi Okada, Satoshi Ono
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:1492-1496
2-(2-Aminoethoxy)-1-hydroxyethyl derivatives of bicyclic arenes (naphthalene, thianaphthene, benzofuran, and indole) were prepared and screened for antiamnestic (AA) and antihypoxic (AH) activities which were evaluated by measuring the reversing pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::558d6321c59f09e5eb926266aec24582
https://doi.org/10.1248/cpb.43.1492
https://doi.org/10.1248/cpb.43.1492
Autor:
Tadakazu Takakura, Hisaaki Chaki, Hironori Kotsubo, Shunichi Shiozawa, Tadashi Tanaka, Yukihiko Aikawa, Shuichi Hirono, Keiichi Tsuchida
Publikováno v:
Journal of medicinal chemistry. 49(1)
We designed and synthesized small-molecule activator protein-1 (AP-1) inhibitors based on a three-dimensional (3D) pharmacophore model that we had previously derived from a cyclic decapeptide exhibiting AP-1 inhibitory activity. New AP-1 inhibitors w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6935b55cb5b0c1b86acf56fd080b3752
https://pubmed.ncbi.nlm.nih.gov/16392794
https://pubmed.ncbi.nlm.nih.gov/16392794
Autor:
Keiichi, Tsuchida, Hisaaki, Chaki, Tadakazu, Takakura, Junichi, Yokotani, Yukihiko, Aikawa, Shunichi, Shiozawa, Hiroaki, Gouda, Shuichi, Hirono
Publikováno v:
Journal of medicinal chemistry. 47(17)
The transcription factor activator protein-1 (AP-1) is an attractive target for the treatment of immunoinflammatory diseases, such as rheumatoid arthritis. Using the three-dimensional (3D) X-ray crystallographic structure of the DNA-bound basic regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5950165972d6dfd718dd1013fabe1bbc
https://pubmed.ncbi.nlm.nih.gov/15293995
https://pubmed.ncbi.nlm.nih.gov/15293995
Autor:
Kuniko Mozumi, Hisaaki Chaki, Kazunori Kitamura, Yasushi Nakada, Tetsuo Yamafuji, Tatsuo Kimura, Mutsuko Maekawa, Satoshi Ono, Hirokazu Narita, Yozo Todo
Publikováno v:
Biologicalpharmaceutical bulletin. 18(12)
The title compound (T-588) has been evaluated for its ameliorating effect on memory impairment generated by cerebral embolization and by a basal forebrain (BF) lesion in male Wistar rats. The memory and learning deficits induced by injection of carbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0545c9ab0ca98b34f2c3a20b521d0e36
https://pubmed.ncbi.nlm.nih.gov/8787808
https://pubmed.ncbi.nlm.nih.gov/8787808
Autor:
Masaru Tai, Hisaaki Chaki, Tetsuo Yamafuji, Mutsuko Maekawa, Satoshi Ono, Hirokazu Narita, Yozo Todo, Kazunori Kitamura
Publikováno v:
Chemicalpharmaceutical bulletin. 43(9)
N-(2-Dimethylaminoethyl)carboxamide (1a-d), 2-dimethylaminoethyl alkyl ether (2a, b), and 2-dimethylaminoethyl 2-hydroxy-2-phenethyl ether (3a-c) and its amino and methylene analogues (3d, 4) have been screened for antiamnestic and antihypoxic activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc730869eca9846d7572cb0240bc384
https://pubmed.ncbi.nlm.nih.gov/7586070
https://pubmed.ncbi.nlm.nih.gov/7586070
Autor:
Yozo Todo, Masaru Tai, Mutsuko Maekawa, Hirokazu Narita, Satoshi Ono, Hajime Morita, Tetsuo Yamafuji, Kazunori Kitamura, Hisaaki Chaki
Publikováno v:
Chemicalpharmaceutical bulletin. 43(9)
A series of 2-(2-aminoethoxy)-1-phenylethanols having a variety of N- and phenyl-substitution patterns as well as 5- and 6-membered heteroaryl counterparts of our prototype compound 1 (2-(2-dimethylaminoethoxy)-1-phenylethanol) have been prepared and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d510231566dc6466f79d49611535d82
https://pubmed.ncbi.nlm.nih.gov/7586071
https://pubmed.ncbi.nlm.nih.gov/7586071
Publikováno v:
Chemical and Pharmaceutical Bulletin. 32:1232-1235
Riboflavin undergoes a characteristic biphasic photolysis with a low-intensity light source, depending on the ionic strength of the phosphate buffer used. In higher ionic strength phosphate buffer, an initial faster phase is followed by a slower seco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7b2d8e6f894cd5326817d0281e60094
https://doi.org/10.1248/cpb.32.1232
https://doi.org/10.1248/cpb.32.1232
Publikováno v:
Annals of the New York Academy of Sciences. 471:316-317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1327f08ebf511668ea25cc2a19f35739
https://doi.org/10.1111/j.1749-6632.1986.tb48053.x
https://doi.org/10.1111/j.1749-6632.1986.tb48053.x