Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hiruy S. Meharena"'
Autor:
L. Ashley Watson, Hiruy S. Meharena
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Down syndrome (DS), caused by triplication of chromosome 21, is the most frequent aneuploidy observed in the human population and represents the most common genetic form of intellectual disability and early-onset Alzheimer’s disease (AD). Individua
Externí odkaz:
https://doaj.org/article/9d16e109b8cf4c039dc006dec7dbb3ce
Autor:
Hiruy S Meharena, Xiaorui Fan, Lalima G Ahuja, Malik M Keshwani, Christopher L McClendon, Angela M Chen, Joseph A Adams, Susan S Taylor
Publikováno v:
PLoS Biology, Vol 14, Iss 11, p e2000127 (2016)
Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformati
Externí odkaz:
https://doaj.org/article/a9ecdc8883d341479d40aa5acbc5baa1
Autor:
Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsai
SummaryApolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing late- onset Alzheimer’s disease and its expression in microglia is associated with pro- inflammatory states. How the interaction of APOE4 microglia with neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e65379af953ea122df84bcbf9fcdeb2
https://doi.org/10.1101/2022.03.21.484146
https://doi.org/10.1101/2022.03.21.484146
Autor:
Hiruy S. Meharena, Asaf Marco, Vishnu Dileep, Elana R. Lockshin, Grace Y. Akatsu, James Mullahoo, L. Ashley Watson, Tak Ko, Lindsey N. Guerin, Fatema Abdurrob, Shruthi Rengarajan, Malvina Papanastasiou, Jacob D. Jaffe, Li-Huei Tsai
Publikováno v:
Cell Stem Cell
Down syndrome (DS) is a genetic disorder driven by the triplication of chromosome 21 (T21) that is characterized by a wide-range of neurodevelopmental and physical disabilities. Transcriptomic analysis of tissue samples from individuals with DS has r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3119ac0c9f90e9f1bf1a47524a9b8a
https://europepmc.org/articles/PMC8805993/
https://europepmc.org/articles/PMC8805993/
Autor:
Morgan A Pence, Nina M Haste, Hiruy S Meharena, Joshua Olson, Richard L Gallo, Victor Nizet, Sascha A Kristian
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136605 (2015)
BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S. aureus Newman for susceptibility to cathelicidin antimicrobial peptide, we discovered BlaI as
Externí odkaz:
https://doaj.org/article/eaf0b834087e49beb6fc54aed36b44d3
Publikováno v:
IUBMB Life
IUBMB life, vol 71, iss 6
IUBMB life, vol 71, iss 6
Eukaryotic protein kinases (EPKs) regulate almost every biological process and have evolved to be dynamic molecular switches; this is in stark contrast to metabolic enzymes, which have evolved to be efficient catalysts. In particular, the highly cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd64b4eddc26802d190f2e08b0c095b1
https://doi.org/10.1002/iub.2059
https://doi.org/10.1002/iub.2059
Autor:
Hiruy S Meharena, Philip Chang, Malik M Keshwani, Krishnadev Oruganty, Aishwarya K Nene, Natarajan Kannan, Susan S Taylor, Alexandr P Kornev
Publikováno v:
PLoS Biology, Vol 11, Iss 10, p e1001680 (2013)
Eukaryotic protein kinases (EPKs) regulate numerous signaling processes by phosphorylating targeted substrates through the highly conserved catalytic domain. Our previous computational studies proposed a model stating that a properly assembled nonlin
Externí odkaz:
https://doaj.org/article/673b41e94bd94b768a3f58fd8f8b984b
Autor:
Jose Davila-Velderrain, Vishnu Dileep, Jennie Z. Young, Ravikiran M. Raju, Chinnakkaruppan Adaikkan, Hiruy S. Meharena, Fan Gao, Manolis Kellis, Asaf Marco, Li-Huei Tsai, Amy Letao Zhang
Publikováno v:
Nature neuroscience
The epigenome and three-dimensional (3D) –genomic architecture are emerging as key factors in the dynamic regulation of different transcriptional programs required for neuronal functions. Here we utilize an activity-dependent tagging system in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15fbc6836942658ef3557511dd893fd
https://pubmed.ncbi.nlm.nih.gov/33020654
https://pubmed.ncbi.nlm.nih.gov/33020654
Autor:
Susan S. Taylor, Lalima G. Ahuja, Alexandr P. Kornev, Hiruy S. Meharena, Natarajan Kannan, Andrey S. Shaw, Jiancheng Hu
Publikováno v:
Molecular and cellular biology, vol 35, iss 1
A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase activation. Here, we examined mutations in human cancer for clues about the regulation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e0e3c03db48133824ffd10cc4e076c
https://doi.org/10.1128/mcb.00943-14
https://doi.org/10.1128/mcb.00943-14
Publikováno v:
Biochemical Society Transactions. 41:981-986
The catalytic (C) subunit of PKA was the first protein kinase structure to be solved, and it continues to serve as the prototype for the protein kinase superfamily. In contrast, by comparing many active and inactive kinases, we developed a novel ‘s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbadb6137923f983f0a99a48f3f42807
https://doi.org/10.1042/bst20130120
https://doi.org/10.1042/bst20130120