Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

Autor: Xiao, Bin, Zuo, Dongmei, Hirukawa, Alison, Cardiff, Robert D., Lamb, Richard, Sonenberg, Nahum, Muller, William J.

Publikováno v: In Cell Reports 28 April 2020 31(4)

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An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic 2 reprogramming and mammary tumourigenesis

Autor: Smith, Harvey W, Hirukawa, Alison, Sanguin-Gendreau, Virginie, Nandi, Ipshita, Dufour, Catherine R, Zuo, Dongmei, Tandoc, Kristofferson, Leibovitch, Matthew, Singh, Salendra, Rennhack, Jonathan, Swiatnicki, Matthew, Lavoie, Cynthia, Papavasiliou, Vasilios, Temps, Carolin, Carragher, Neil, Unciti-Broceta, Asier, Savage, Paul, Basik, Mark, van Hoef, Vincent, Larsson, Ola, Cooper, Caroline L, Calderon, Ana Cristina Vargas, Beith, Jane, Millar, Ewan, Selinger, Christina, Giguère, Vincent, Park, Morag, Harris, Lyndsey R, Varadan, Vinay, Andrechek, Eran, O'Toole, Sandra A, Topisirovic, Ivan, Muller, William J

Publikováno v: Smith, H W, Hirukawa, A, Sanguin-Gendreau, V, Nandi, I, Dufour, C R, Zuo, D, Tandoc, K, Leibovitch, M, Singh, S, Rennhack, J, Swiatnicki, M, Lavoie, C, Papavasiliou, V, Temps, C, Carragher, N, Unciti-Broceta, A, Savage, P, Basik, M, van Hoef, V, Larsson, O, Cooper, C L, Calderon, A C V, Beith, J, Millar, E, Selinger, C, Giguère, V, Park, M, Harris, L R, Varadan, V, Andrechek, E, O'Toole, S A, Topisirovic, I & Muller, W J 2019, ' An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic 2 reprogramming and mammary tumourigenesis ', Nature Communications . https://doi.org/10.1038/s41467-019-10681-4

Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2). However, the role of EZH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::02577d115160bd49655e9dec3d10a333
https://hdl.handle.net/20.500.11820/f8ed5961-3469-4b56-a87f-2b4be06c7021

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The role of SHIP1 in modulating disease severity in the K/BxN serum transfer model of rheumatoid arthritis

Autor: Hirukawa, Alison Misa

SHIP1 (SH2 domain containing inositol-5ʼ-phosphatase) is a negative regulator of the phosphatidylinositol-3 kinase (PI3K) pathway. SHIP1 is expressed in hematopoietic cells, and mediates its effect by hydrolyzing PIP₃, an important second messenge

Externí odkaz: http://hdl.handle.net/2429/36676