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No evidence of ongoing evolution in replication competent latent HIV-1 in a patient followed up for two years
Autor: Mok, Hoi Ping, Norton, Nicholas J., Hirst, Jack C, Fun, Axel, Bandara, Mikaila, Wills, Mark R., Lever, Andrew M. L.
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
Scientific Reports
The persistence of infected T cells harbouring intact HIV proviruses is the barrier to the eradication of HIV. This reservoir is stable over long periods of time despite antiretroviral therapy. There has been controversy on whether low level viral re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c497eeb0605b29b81b183fa9df7ea058
http://link.springer.com/article/10.1038/s41598-018-20682-w
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6
Single-particle Measurements Reveal Damage to Filamentous Influenza Virions During Laboratory Handling [Poster]
Autor: Hirst, Jack C., Burke, Amy, Hutchinson, Edward C.
Most laboratory strains of influenza virus produce near-spherical virions, but clinical isolates also produce extended filaments whose biophysical properties are understudied. Most functional studies of filamentous influenza viruses do not include da
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a6a3a52e4a4d9024ac47d0ab74e374be
https://eprints.gla.ac.uk/185536/2/185536.pdf
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7
Altering the Size Distribution of Influenza Virion Populations [Poster]
Autor: Burke, Amy, Hirst, Jack C., Hutchinson, Edward C.
Harry Smith Vacation Studentship Laboratory-adapted influenza viruses produce predominantly spherical virions. In contrast, clinical and veterinary isolates produce a mixture of virions of different sizes, from 0.1 µm spheres to filaments which can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ca8aa7a164e339619c9e3bb173f83373
https://eprints.gla.ac.uk/185546/2/185546.pdf
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9
Do mutations in the tat exonic splice enhancer contribute to HIV-1 latency?
Autor: Norton, Nicholas, Mok, Hoi Ping, Hirst, Jack, Lever, Andrew
Latent infection of long-lived memory CD4+ T cells is thought to be a major barrier to the eradication of HIV-1. Globally there is a substantial research effort aimed at disrupting latency to enable the purging of the latent reservoir. Despite maxima
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47028d3ed49654c028101f341a5d6fb6
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The majority of reactivatable latent HIV are genetically distinct
Autor: Mok, Hoi Ping, Norton, Nicholas, Fun, Axel, Hirst, Jack, Wills, Mark, Lever, Andrew
The clonality of latent HIV has been inferred from viral sequences derived from various sources, including proviruses, residual viraemia of patients stable on treatment, and rebound viraemia in patients who have undergone treatment interruption. It h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83ec7561102593792991186463dbe543
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