The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2.

Autor: Bao L; Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA., Festa F; Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA.; Departments of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA., Freet CS; Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA., Lee JP; Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA., Hirschler-Laszkiewicz IM; Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA., Chen SJ; Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA., Keefer KA; Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA., Wang HG; Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA.; Departments of Phamacology, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA., Patterson AD; Department of Molecular Toxicology, The Pennsylvania State University, University Park, Pennsylvania, USA., Cheung JY; The Center of Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, 19140, USA.; Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, 19140, USA., Miller BA; Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA. bmiller3@pennstatehealth.psu.edu.; Departments of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA. bmiller3@pennstatehealth.psu.edu.

Publikováno v: Scientific reports [Sci Rep] 2019 Oct 01; Vol. 9 (1), pp. 14132. Date of Electronic Publication: 2019 Oct 01.