Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Hiroyuki Yoneyama"'
Autor:
Kenji Suzuki, Yukinori Sameshima, Junji Yokoyama, Shuji Terai, Hiroyuki Yoneyama, Raja Atreya, Markus F. Neurath, Toshifumi Hibi, Hitoshi Asakura
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-10 (2024)
Abstract Background Carbohydrate sulfotransferase 15 (CHST15) is an enzyme biosynthesizing matrix glycosaminoglycan that modulates tissue remodeling. We evaluated the efficacy of add-on submucosal injections of GUT-1, the RNA oligonucleotide inhibito
Externí odkaz:
https://doaj.org/article/4d12c4d2ddc145778e89ea6704cc7480
Autor:
Yoshiro Kai, Koichi Tomoda, Hiroyuki Yoneyama, Masahiro Kitabatake, Atsuhiro Nakamura, Toshihiro Ito, Masanori Yoshikawa, Hiroshi Kimura
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 163-172 (2017)
Pulmonary fibrosis is a progressive lung disorder characterized by interstitial fibrosis, for which no effective treatments are available. Chondroitin sulfate proteoglycan (CSPG) has been shown to be a mediator, but the specific component of glycosam
Externí odkaz:
https://doaj.org/article/0d8ac45bab644564afe02cff9bb09171
Autor:
Yusuke Kitazawa, Hisashi Ueta, Yasushi Sawanobori, Tomoya Katakai, Hiroyuki Yoneyama, Satoshi Ueha, Kouji Matsushima, Nobuko Tokuda, Kenjiro Matsuno
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Vaccination strategy that induce efficient antibody responses polytopically in most lymph nodes (LNs) against infections has not been established yet. Because donor-specific blood transfusion induces anti-donor class I MHC antibody production in sple
Externí odkaz:
https://doaj.org/article/c1c18ae551c54cc9a72c1d641352e0d2
Autor:
Kenji Suzuki, Somasundaram Arumugam, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, Hiroki Sato, Yutaka Aoyagi, Shuji Terai, Kazuichi Okazaki, Yasuo Suzuki, Shuji Mizumoto, Kazuyuki Sugahara, Raja Atreya, Markus F Neurath, Kenichi Watanabe, Taishi Hashiguchi, Hiroyuki Yoneyama, Hitoshi Asakura
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158967 (2016)
Induction of mucosal healing (MH) is an important treatment goal in inflammatory bowel disease (IBD). Although the molecular mechanisms underlying MH in IBD is not fully explored, local fibrosis would contribute to interfere mucosal repair. Carbohydr
Externí odkaz:
https://doaj.org/article/bdc39cdabfa94c89bba24d1bfc1d6290
Autor:
Eric Lefebvre, Graeme Moyle, Ran Reshef, Lee P Richman, Melanie Thompson, Feng Hong, Hsin-L Chou, Taishi Hashiguchi, Craig Plato, Dominic Poulin, Toni Richards, Hiroyuki Yoneyama, Helen Jenkins, Grushenka Wolfgang, Scott L Friedman
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158156 (2016)
Interactions between C-C chemokine receptor types 2 (CCR2) and 5 (CCR5) and their ligands, including CCL2 and CCL5, mediate fibrogenesis by promoting monocyte/macrophage recruitment and tissue infiltration, as well as hepatic stellate cell activation
Externí odkaz:
https://doaj.org/article/c55b992cf7f4495ba5f645d25ee018aa
Autor:
Kazuki Takakura, Yuichiro Shibazaki, Hiroyuki Yoneyama, Masato Fujii, Taishi Hashiguchi, Zensho Ito, Mikio Kajihara, Takeyuki Misawa, Sadamu Homma, Toshifumi Ohkusa, Shigeo Koido
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0142981 (2015)
Chondroitin sulfate E (CS-E), a highly sulfated glycosaminoglycan, is known to promote tumor invasion and metastasis. Because the presence of CS-E is detected in both tumor and stromal cells in pancreatic ductal adenocarcinoma (PDAC), multistage invo
Externí odkaz:
https://doaj.org/article/ba5c26a1fa7e47eb9fdc848fc6f18bc2
Publikováno v:
Clinical and Developmental Immunology, Vol 9, Iss 3, Pp 143-149 (2002)
Externí odkaz:
https://doaj.org/article/5029ec02e9a44395873586ceb9e2198a
Publikováno v:
Respiratory Investigation. 59:576-588
Fibrosis is characterized by the deposition of extracellular matrix (ECM) proteins, while idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease characterized by dysregulated tissue repair and remodeling. Anti-inflammatory drugs, such a
Publikováno v:
Plankton and Benthos Research. 15:78-96
Autor:
Juanjuan Ye, Futoshi Suizu, Keiko Yamakawa, Motohiko Kato, Takayoshi Tsuchiya, Hiroyuki Yoneyama, Naohisa Yahagi, Yoko Matsuda
Publikováno v:
Journal of Clinical Oncology. 40:e16241-e16241
e16241 Background: Limited T cell infiltration within immunosuppressive microenvironment is still a hurdle for immune checkpoint inhibition therapies in pancreatic cancer. Carbohydrate sulfotransferase 15 (CHST15) is a proteoglycan biosynthetic enzym