Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Hiroyuki Yamano"'
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114262- (2024)
Summary: The anaphase-promoting complex/cyclosome (APC/C) is a critical and tightly regulated E3 ligase that orchestrates the cellular life cycle by controlling the degradation of cell cycle regulators. An intriguing feature of this complex is an aut
Externí odkaz:
https://doaj.org/article/f9c736b7e15a4c4bab2cc12d41aaa0f8
Autor:
Kim Hou Chia, Hiroko Takaki, Kazuyuki Fujimitsu, Sarah Darling, Juan Zou, Juri Rappsilber, Hiroyuki Yamano
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114155- (2024)
Summary: Cell cycle control relies on a delicate balance of phosphorylation with CDK1 and phosphatases like PP1 and PP2A-B55. Yet, identifying the primary substrate responsible for cell cycle oscillations remains a challenge. We uncover the pivotal r
Externí odkaz:
https://doaj.org/article/35866ab49860443e8550a7f6c98ee1ba
Autor:
Satsuki Miyazaki, Hiroyuki Yamano, Daisuke Motooka, Fumi Tashiro, Takumi Matsuura, Tatsushi Miyazaki, Jun-ichi Miyazaki
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse embryonic stem cells (ESCs) but rapidly decreases following differentiation. Zfp296-knockout (KO) ESCs grew as flat colonies, which were reverted to rounded
Externí odkaz:
https://doaj.org/article/56ecfb3f40464fb3b48b41d4eb08d316
Autor:
Richard J. Wall, David J. P. Ferguson, Aline Freville, Blandine Franke-Fayard, Declan Brady, Mohammad Zeeshan, Andrew R. Bottrill, Sally Wheatley, Andrew M. Fry, Chris J. Janse, Hiroyuki Yamano, Anthony A. Holder, David S. Guttery, Rita Tewari
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The anaphase promoting complex/cyclosome (APC/C) is a highly conserved multi-subunit E3 ubiquitin ligase that controls mitotic division in eukaryotic cells by tagging cell cycle regulators for proteolysis. APC3 is a key component that contri
Externí odkaz:
https://doaj.org/article/c4146aca53b342b192bb9f54c10c319c
Autor:
Hiroyuki Yamano
Publikováno v:
F1000Research, Vol 8 (2019)
The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most important irrevocable event during the cell cycle. The APC/C and cyclin-depend
Externí odkaz:
https://doaj.org/article/466802ec17f141048781677faebd9613
Autor:
Francesco Meghini, Torcato Martins, Xavier Tait, Kazuyuki Fujimitsu, Hiroyuki Yamano, David M. Glover, Yuu Kimata
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C act
Externí odkaz:
https://doaj.org/article/faaaa862e214408085422a57ff18cb1a
Autor:
Manuel Eguren, Mónica Álvarez-Fernández, Fernando García, Andrés J. López-Contreras, Kazuyuki Fujimitsu, Hiroko Yaguchi, José Luis Luque-García, Oscar Fernández-Capetillo, Javier Muñoz, Hiroyuki Yamano, Marcos Malumbres
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 670-683 (2014)
The Anaphase-promoting complex/cyclosome (APC/C) cofactor Cdh1 modulates cell proliferation by targeting multiple cell-cycle regulators for ubiquitin-dependent degradation. Lack of Cdh1 results in structural and numerical chromosome aberrations, a ha
Externí odkaz:
https://doaj.org/article/bed4c090d468497d93616232c9fc782a
Autor:
Meghna Kataria, Hiroyuki Yamano
Publikováno v:
Cells, Vol 8, Iss 8, p 814 (2019)
Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis. Protein pho
Externí odkaz:
https://doaj.org/article/65f7f3a5e8be4a00b4ffa656c8dbf944
Autor:
Magali Roques, Richard J Wall, Alexander P Douglass, Abhinay Ramaprasad, David J P Ferguson, Mbinda L Kaindama, Lorenzo Brusini, Nimitray Joshi, Zineb Rchiad, Declan Brady, David S Guttery, Sally P Wheatley, Hiroyuki Yamano, Anthony A Holder, Arnab Pain, Bill Wickstead, Rita Tewari
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005273 (2015)
Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisi
Externí odkaz:
https://doaj.org/article/9d00b0910463472693797595a9f28ce8
Autor:
Hiroyuki Yamano, Kazuyuki Fujimitsu
Publikováno v:
The EMBO Journal
The anaphase‐promoting complex/cyclosome (APC/C), a multi‐subunit ubiquitin ligase essential for cell cycle control, is regulated by reversible phosphorylation. APC/C phosphorylation by cyclin‐dependent kinase 1 (Cdk1) promotes Cdc20 co‐activ