Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Hiroyuki Unoki"'
Autor:
Daishi Hirano, Hiroyuki Unoki‐Kubota, Toshiyuki Imasawa, Ritsuko Yamamoto‐Honda, Hiroshi Kajio, Shigeo Yamashita, Yuka Fukazawa, Naoto Seki, Mitsuhiko Noda, Yasushi Kaburagi
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 7, Pp 874-882 (2023)
Abstract Aims/Introduction Research on the incidence and underlying mechanisms of rapid renal function decline in patients with type 2 diabetes mellitus with preserved renal function and normoalbuminuria is limited. This study aimed to investigate th
Externí odkaz:
https://doaj.org/article/be35dbb63a114e608ec1b859e3324b11
Autor:
Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida, Masaaki Uematsu, Kazuki Nakao, Harumi Nakao, Atsu Aiba, Yoji Nagashima, Tetsuya Kubota, Naoto Kubota, Yoshihiko Izumida, Naoya Yahagi, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Shun-ichiro Asahara, Yoshiaki Kido, Hideo Shindou, Michiko Itoh, Yoshihiro Ogawa, Shiro Minami, Yasuo Terauchi, Kazuyuki Tobe, Kohjiro Ueki, Masato Kasuga, Michihiro Matsumoto
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes are interacting comorbidities of obesity, and increased hepatic de novo lipogenesis (DNL), driven by hyperinsulinemia and carbohydrate overload, contributes to their pathogenesis. Fatty aci
Externí odkaz:
https://doaj.org/article/e5ab1c9c4a954f56823c71beefd37326
Autor:
Akinori Okumura, Takeshi Saito, Minoru Tobiume, Yuki Hashimoto, Yuko Sato, Takashi Umeyama, Minoru Nagi, Koichi Tanabe, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Hideki Hasegawa, Yoshitsugu Miyazaki, Satoshi Yamagoe
Publikováno v:
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 166-171 (2017)
Leukocyte cell-derived chemotaxin 2 (LECT2) is a secreted pleiotropic protein that is mainly produced by the liver. We have previously shown that LECT2 plays an important role in the pathogenesis of inflammatory liver diseases. Lipopolysaccharide/d-g
Externí odkaz:
https://doaj.org/article/283ff08a69874c67afbad139a8aca5a9
Autor:
Wakiko Iwata, Hiroyuki Unoki-Kubota, Hideki Kato, Akira Shimizu, Michihiro Matsumoto, Toshiyuki Imasawa, Arisa Igarashi, Kenji Matsumoto, Tetsuo Noda, Yasuo Terauchi, Masaomi Nangaku, Masato Kasuga, Yasushi Kaburagi
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229397 (2020)
Obesity can initiate and accelerate the progression of kidney diseases. However, it remains unclear how obesity affects renal dysfunction. Here, we show that a newly generated podocyte-specific tubular sclerosis complex 2 (Tsc2) knockout mouse model
Externí odkaz:
https://doaj.org/article/2781a5cf89ec49e594b7cf2923e6bc38
Autor:
Mashito Sakai, Tomoko Tujimura-Hayakawa, Takashi Yagi, Hiroyuki Yano, Masaru Mitsushima, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Hiroshi Inoue, Yoshiaki Kido, Masato Kasuga, Michihiro Matsumoto
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
GCN5 inhibits hepatic gluconeogenesis through acetylation of PGC-1α. Here the authors show that GCN5 also activates hepatic gluconeogenesis by acetylating histone H3K9, and that the affinity of GCN5 for its different substrates is regulated via phos
Externí odkaz:
https://doaj.org/article/8001c64b252745a788bee1e6cfee26e3
Autor:
Shiro Maeda, Masa-aki Kobayashi, Shin-ichi Araki, Tetsuya Babazono, Barry I Freedman, Meredith A Bostrom, Jessica N Cooke, Masao Toyoda, Tomoya Umezono, Lise Tarnow, Torben Hansen, Peter Gaede, Anders Jorsal, Daniel P K Ng, Minoru Ikeda, Toru Yanagimoto, Tatsuhiko Tsunoda, Hiroyuki Unoki, Koichi Kawai, Masahito Imanishi, Daisuke Suzuki, Hyoung Doo Shin, Kyong Soo Park, Atsunori Kashiwagi, Yasuhiko Iwamoto, Kohei Kaku, Ryuzo Kawamori, Hans-Henrik Parving, Donald W Bowden, Oluf Pedersen, Yusuke Nakamura
Publikováno v:
PLoS Genetics, Vol 6, Iss 2, p e1000842 (2010)
It has been suggested that genetic susceptibility plays an important role in the pathogenesis of diabetic nephropathy. A large-scale genotyping analysis of gene-based single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes id
Externí odkaz:
https://doaj.org/article/351019a1b8e447ccb64a66a67903a95b
Autor:
Johan Holmkvist, Karina Banasik, Gitte Andersen, Hiroyuki Unoki, Thomas Skot Jensen, Charlotta Pisinger, Knut Borch-Johnsen, Annelli Sandbaek, Torsten Lauritzen, Sören Brunak, Shiro Maeda, Torben Hansen, Oluf Pedersen
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5872 (2009)
BackgroundPolymorphisms in the potassium channel, voltage-gated, KQT-like subfamily, member 1 (KCNQ1) have recently been reported to associate with type 2 diabetes. The primary aim of the present study was to investigate the putative impact of these
Externí odkaz:
https://doaj.org/article/0d58a0cd81f841f78d30959a06c09843
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS The pathogenesis of low-birth-weight (LBW)-related nephropathy has been considered to be the result of intra-glomerular hyperfiltration during growth due to the presence of low nephron numbers. On the other hand, we hypothesized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e0d7fbdc9fdba1b19d839cfd5b6df7b
https://doi.org/10.1093/ndt/gfac070.040
https://doi.org/10.1093/ndt/gfac070.040
Autor:
Masahiro Ishikane, Hiroyuki Unoki-Kubota, Ataru Moriya, Satoshi Kutsuna, Honami Ando, Yasushi Kaburagi, Tetsuya Suzuki, Noriko Iwamoto, Moto Kimura, Norio Ohmagari
Publikováno v:
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 28(6)
Rapid, simple, and accurate methods are required to diagnose coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to evaluate the performance of the QIAstat-Dx Respirat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e178322ac8e96954c8aa2abdc0f8ad
https://pubmed.ncbi.nlm.nih.gov/35184977
https://pubmed.ncbi.nlm.nih.gov/35184977
Autor:
Yasushi Kaburagi, Wakiko Iwata, Hiroyuki Unoki-Kubota, Michihiro Matsumoto, Masaomi Nangaku, Hideki Kato
Publikováno v:
Diabetes. 69
In diabetic states, altered activity of insulin signaling pathway is likely to play key roles in insulin resistance and in kidney dysfunction. Since the 3-phosphoinositide-dependent protein kinase 1 (PDK1) serves as a major signaling molecule in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a1edfe12aa5b74a258f2af36594ac9d
https://doi.org/10.2337/db20-468-p
https://doi.org/10.2337/db20-468-p