Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Hiroyuki Tsunoda"'
Autor:
Kana Ohashi, Yukari Nishito, Hironori Fukuda, Ryoichi Sadahiro, Yukihiro Yoshida, Shun-ichi Watanabe, Noriko Motoi, Yukiko Sonobe, Hideaki Mizuno, Hiroyuki Tsunoda, Koichiro Tatsumi, Takuji Suzuki, Atsushi Ochiai, Kazunori Aoki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Inflammatory factors in the peripheral blood, such as the C-reactive protein level and neutrophil-to-lymphocyte ratio (NLR), are prognostic markers in multiple types of cancer, including non-small cell lung cancer (NSCLC). However, the assoc
Externí odkaz:
https://doaj.org/article/4096f7b13c4641aa876bf2b5a00a8b84
Autor:
Taro Kakuzaki, Hikaru Koga, Shuuki Takizawa, Shoichi Metsugi, Hirotake Shiraiwa, Zenjiro Sampei, Kenji Yoshida, Hiroyuki Tsunoda, Reiji Teramoto
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibodies are one of the predominant treatment modalities for various diseases. To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively expl
Externí odkaz:
https://doaj.org/article/464d1ce6486045f391b77c27fa515809
Autor:
Koichiro Saka, Taro Kakuzaki, Shoichi Metsugi, Daiki Kashiwagi, Kenji Yoshida, Manabu Wada, Hiroyuki Tsunoda, Reiji Teramoto
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Molecular evolution is an important step in the development of therapeutic antibodies. However, the current method of affinity maturation is overly costly and labor-intensive because of the repetitive mutation experiments needed to adequatel
Externí odkaz:
https://doaj.org/article/b637d0a8f2934168ad948f2310d11803
Autor:
Shinichi Onishi, Riku Egami, Yuya Nakamura, Yoshinobu Nagashima, Kaori Nishihara, Saori Matsuo, Atsuko Murai, Shuji Hayashi, Yoshifumi Uesumi, Atsuhiko Kato, Hiroyuki Tsunoda, Masaki Yamazaki, Hideaki Mizuno
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100120- (2022)
Assessment of the estrous cycle of mature female mammals is an important component of verifying the efficacy and safety of drug candidates. The common pathological approach of relying on expert observation has several drawbacks, including laborious w
Externí odkaz:
https://doaj.org/article/877b08a55b0748739108377e4999497f
Autor:
Taku Fukuzawa, Zenjiro Sampei, Kenta Haraya, Yoshinao Ruike, Meiri Shida-Kawazoe, Yuichiro Shimizu, Siok Wan Gan, Machiko Irie, Yoshinori Tsuboi, Hitoshi Tai, Tetsushi Sakiyama, Akihisa Sakamoto, Shinya Ishii, Atsuhiko Maeda, Yuki Iwayanagi, Norihito Shibahara, Mitsuko Shibuya, Genki Nakamura, Takeru Nambu, Akira Hayasaka, Futa Mimoto, Yuu Okura, Yuji Hori, Kiyoshi Habu, Manabu Wada, Takaaki Miura, Tatsuhiko Tachibana, Kiyofumi Honda, Hiroyuki Tsunoda, Takehisa Kitazawa, Yoshiki Kawabe, Tomoyuki Igawa, Kunihiro Hattori, Junichi Nezu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Dysregulation of the complement system is linked to the pathogenesis of a variety of hematological disorders. Eculizumab, an anti-complement C5 monoclonal antibody, is the current standard of care for paroxysmal nocturnal hemoglobinuria (PNH
Externí odkaz:
https://doaj.org/article/84b20be1cd2e48b4b4a92b1de12240c0
Autor:
Kei Suzuki, Hiroyuki Tsunoda, Ryusuke Omiya, Kyoko Matoba, Takeshi Baba, Sachiyo Suzuki, Hiroaki Segawa, Atsushi Kumanogoh, Kenji Iwasaki, Kunihiro Hattori, Junichi Takagi
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156719 (2016)
Semaphorin family proteins act on cells to mediate both repulsive and attractive guidance via binding to plexin family receptors, thereby playing fundamental roles in the morphogenesis and homeostasis of various tissues. Although semaphorin-plexin si
Externí odkaz:
https://doaj.org/article/2e0d38caa8bf4da399a0005b1372ceec
Autor:
Hiroyuki TSUNODA, Jun-ichi TAKEI
Publikováno v:
Journal of Fluid Science and Technology, Vol 1, Iss 2, Pp 105-113 (2006)
The concentration field of a diffusing matter in the cross plane of a turbulent round jet injected into a counter-flowing uniform stream has been investigated using the PLIF technique. In order to capture images in good focus from a camera oriented o
Externí odkaz:
https://doaj.org/article/e13b414323884ff9a3ce60abda8aab70
Autor:
Tomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, Tatsuhiko Tachibana, Yuki Iwayanagi, Futa Mimoto, Yoshinobu Higuchi, Shinya Ishii, Shigero Tamba, Naoka Hironiwa, Kozue Nagano, Tetsuya Wakabayashi, Hiroyuki Tsunoda, Kunihiro Hattori
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63236 (2013)
Monoclonal antibodies are widely used to target disease-related antigens. However, because conventional antibody binds to the antigen but cannot eliminate the antigen from plasma, and rather increases the plasma antigen concentration by reducing the
Externí odkaz:
https://doaj.org/article/5e72165db2b0430682a83824010d9f36
Publikováno v:
Proceedings of the Association for Information Science and Technology. 59:505-509
Autor:
Kazunori Aoki, Yukari Nishito, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Tatsuhiro Shibata, Yukiko Sonobe, Yoko Kayukawa, Eri Hashimoto, Mina Takahashi, Etsuko Fujii, Takashi Nishizawa, Hironori Fukuda, Kana Ohashi, Kosuke Arai, Yukihiro Mizoguchi, Yukihiro Yoshida, Shun-ichi Watanabe, Makiko Yamashita, Shigehisa Kitano, Hiromi Sakamoto, Yuki Nagata, Risa Mitsumori, Kouichi Ozaki, Shumpei Niida, Yae Kanai, Akiyoshi Hirayama, Tomoyoshi Soga, Toru Maruyama, Keisuke Tsukada, Nami Yabuki, Mei Shimada, Takehisa Kitazawa, Osamu Natori, Noriaki Sawada, Atsuhiko Kato, Teruhiko Yoshida, Kazuki Yasuda, Hideaki Mizuno, Hiroyuki Tsunoda, Atsushi Ochiai
Publikováno v:
Cancer Research Communications.
Resistance to immune-checkpoint blockade remains challenging in patients with non-small cell lung cancer (NSCLC). Tumor-infiltrating leukocyte (TIL) quantity, composition, and activation status profoundly influence responsiveness to cancer immunother