Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Hiroyuki Seimiya"'
Autor:
Mitsukuni Suenaga, Tetsuo Mashima, Naomi Kawata, Shingo Dan, Hiroyuki Seimiya, Kensei Yamaguchi
Publikováno v:
Cancers, Vol 16, Iss 16, p 2855 (2024)
In identifying biomarkers for anticancer drugs, the lack of objectivity in selecting candidate factors makes interpretation difficult. We performed preclinical analysis and a translational validation study to identify candidate biomarkers for regoraf
Externí odkaz:
https://doaj.org/article/5b7445a2b10840c788ec16581d04dd9b
Autor:
Masatomo Chiba, Kenichi Miyata, Hikaru Okawa, Yoko Tanaka, Koji Ueda, Hiroyuki Seimiya, Akiko Takahashi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16399 (2023)
Senescent cells secrete inflammatory proteins and small extracellular vesicles (sEVs), collectively termed senescence-associated secretory phenotype (SASP), and promote age-related diseases. Epigenetic alteration in senescent cells induces the expres
Externí odkaz:
https://doaj.org/article/652f53f7d49242609024e8301c90eada
Autor:
Tetsuo Mashima, Takeru Wakatsuki, Naomi Kawata, Myung-Kyu Jang, Akiko Nagamori, Haruka Yoshida, Kenichi Nakamura, Toshiro Migita, Hiroyuki Seimiya, Kensei Yamaguchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) axis is an essential regulator of angiogenesis and important therapeutic target in cancer. Ramucirumab is an anti-VEGFR2 monoclonal antibody used for the treatment of severa
Externí odkaz:
https://doaj.org/article/422426adde034efd8700a487b51f4081
Autor:
Chiaki Fujiwara, Yukiko Muramatsu, Megumi Nishii, Kazuhiro Tokunaka, Hidetoshi Tahara, Masaru Ueno, Takao Yamori, Yoshikazu Sugimoto, Hiroyuki Seimiya
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Telomere maintenance by telomerase activity supports the infinite growth of cancer cells. MST-312, a synthetic telomerase inhibitor, gradually shortens telomeres at non-acute lethal doses and eventually induces senescence and apoptosis of te
Externí odkaz:
https://doaj.org/article/bcff0d57a37a40e7bac59241a17f8c5f
Autor:
Takahiro Nakamura, Sachiko Okabe, Haruka Yoshida, Keisuke Iida, Yue Ma, Shogo Sasaki, Takao Yamori, Kazuo Shin-ya, Ichiro Nakano, Kazuo Nagasawa, Hiroyuki Seimiya
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract G-quadruplex (G4) is a higher-order nucleic acid structure that is formed by guanine-rich sequences. G4 stabilization by small-molecule compounds called G4 ligands often causes cytotoxicity, although the potential medicinal impact of this ef
Externí odkaz:
https://doaj.org/article/3aa433890e6a4fbf9414876c5f696dba
Autor:
Keiji Okamoto, Hiroyuki Seimiya
Publikováno v:
Cells, Vol 8, Iss 2, p 107 (2019)
Telomeres, the protective structures of chromosome ends are gradually shortened by each cell division, eventually leading to senescence or apoptosis. Cancer cells maintain the telomere length for unlimited growth by telomerase reactivation or a recom
Externí odkaz:
https://doaj.org/article/659adc5258fc4707830b3e5da945f295
Publikováno v:
Molecules, Vol 18, Iss 4, Pp 4328-4341 (2013)
Macrocyclic hexaoxazole dimer of L2H2-6OTD-dimer (3) was newly synthesized as a telomeric G-quadruplex (G4) ligand, and interaction with long telomeric DNAs telo48, 72, and 96 was evaluated by means of electrophoresis mobility shift assay, CD spectra
Externí odkaz:
https://doaj.org/article/8927c15d8259426ba113e79bacd0dc41
Autor:
Akira Shimamoto, Harunobu Kagawa, Kazumasa Zensho, Yukihiro Sera, Yasuhiro Kazuki, Mitsuhiko Osaki, Mitsuo Oshimura, Yasuhito Ishigaki, Kanya Hamasaki, Yoshiaki Kodama, Shinsuke Yuasa, Keiichi Fukuda, Kyotaro Hirashima, Hiroyuki Seimiya, Hirofumi Koyama, Takahiko Shimizu, Minoru Takemoto, Koutaro Yokote, Makoto Goto, Hidetoshi Tahara
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112900 (2014)
Werner syndrome (WS) is a premature aging disorder characterized by chromosomal instability and cancer predisposition. Mutations in WRN are responsible for the disease and cause telomere dysfunction, resulting in accelerated aging. Recent studies hav
Externí odkaz:
https://doaj.org/article/022f8c96cdef46b1aa9ece260e7121c0
Autor:
Hiroyuki Seimiya
Publikováno v:
EBioMedicine, Vol 2, Iss 8, Pp 804-805 (2015)
Externí odkaz:
https://doaj.org/article/966d8d2482f441d5876bddd8eae80fe3
Autor:
Hiroyuki Seimiya, Yoshikazu Sugimoto, Naoya Fujita, Satoshi Nagayama, Ryohei Katayama, Masaaki Matsuura, Kento Nakata, Yukiko Muramatsu, Haruka Yoshida, Bo Gong, Aki Aoyama, Ayana Sato, Anna Mizutani, Tetsuo Mashima, Noritaka Tanaka
In most colorectal cancers, Wnt/β-catenin signaling is activated by loss-of-function mutations in the adenomatous polyposis coli (APC) gene and plays a critical role in tumorigenesis. Tankyrases poly(ADP-ribosyl)ate and destabilize Axins, a negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8058dabfd4016a1add46858c13f4ab3e
https://doi.org/10.1158/1535-7163.c.6538768
https://doi.org/10.1158/1535-7163.c.6538768