Zobrazeno 1 - 10
of 809
pro vyhledávání: '"Hiroyuki Osada"'
Autor:
Taylor Davie, Xènia Serrat, Lea Imhof, Jamie Snider, Igor Štagljar, Jennifer Keiser, Hiroyuki Hirano, Nobumoto Watanabe, Hiroyuki Osada, Andrew G. Fraser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Soil-transmitted helminths (STHs) are major pathogens infecting over a billion people. There are few classes of anthelmintics and there is an urgent need for new drugs. Many STHs use an unusual form of anaerobic metabolism to survive the hyp
Externí odkaz:
https://doaj.org/article/7b162390c2ff406b8a23937a897ef68f
Autor:
Nicole M. Revie, Kali R. Iyer, Michelle E. Maxson, Jiabao Zhang, Su Yan, Caroline M. Fernandes, Kirsten J. Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, Hiram Sanchez, Saif Hossain, Sheena Li, Yoko Yashiroda, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S. Shapiro, David R. Andes, Gerard D. Wright, Justin R. Nodwell, Maurizio Del Poeta, Martin D. Burke, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
There is an urgent need for novel strategies to combat life-threatening fungal infections. Here, Revie et al. identify a compound that induces alterations in fungal membranes, synergizes with azole antifungals against the pathogen Candida albicans, a
Externí odkaz:
https://doaj.org/article/8bca44075efb4f07a12ae3b736c09d4d
Publikováno v:
Fungal Biology and Biotechnology, Vol 9, Iss 1, Pp 1-20 (2022)
Abstract The Diels–Alder (DA) reaction refers to a [4 + 2] cycloaddition reaction that falls under the category of pericyclic reactions. It is a reaction that allows regio- and stereo-selective construction of two carbon–carbon bonds simultaneous
Externí odkaz:
https://doaj.org/article/db512057c3ea4e2786fb824747526a72
Autor:
Naoki Kato, Kana Ebihara, Toshihiko Nogawa, Yushi Futamura, Kazue Inaba, Akiko Okano, Harumi Aono, Yuuta Fujikawa, Hideshi Inoue, Kazuhiko Matsuda, Hiroyuki Osada, Ryusuke Niwa, Shunji Takahashi
Publikováno v:
PLoS ONE, Vol 18, Iss 8 (2023)
Decalin-containing tetramic acid is a bioactive scaffold primarily produced by filamentous fungi. The structural diversity of this group of compounds is generated by characteristic enzymes of fungal biosynthetic pathways, including polyketide synthas
Externí odkaz:
https://doaj.org/article/005bbb16af3640c180b663d62b781f46
Autor:
Jee Whu Lee, Tee Gee Ong, Mohammed Razip Samian, Aik-Hong Teh, Nobumoto Watanabe, Hiroyuki Osada, Eugene Boon Beng Ong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Ageing-related proteins play various roles such as regulating cellular ageing, countering oxidative stress, and modulating signal transduction pathways amongst many others. Hundreds of ageing-related proteins have been identified, however th
Externí odkaz:
https://doaj.org/article/ec193b9b5b9c43bca7d73167fc27dacb
Autor:
Nobuaki Ishihama, Seung-won Choi, Yoshiteru Noutoshi, Ivana Saska, Shuta Asai, Kaori Takizawa, Sheng Yang He, Hiroyuki Osada, Ken Shirasu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The plant defense hormone salicylic acid has structural similarity to oxicam-type non-steroidal antiinflammatories. Here the authors show oxicams, as well as endogenous salicylic acid, can alter cellular redox state and immune signaling without affec
Externí odkaz:
https://doaj.org/article/2287a9aab2064158bd321dcc81689e62
Autor:
Ju Yeon Moon, Eri Adams, Takae Miyazaki, Yasumitsu Kondoh, Makoto Muroi, Nobumoto Watanabe, Hiroyuki Osada, Ryoung Shin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cesium (Cs) is found at low levels in nature but does not confer any known benefit to plants. Cs and K compete in cells due to the chemical similarity of Cs to potassium (K), and can induce K deficiency in cells. In previous studies, we iden
Externí odkaz:
https://doaj.org/article/5f63f537b6cd4b178e121c548209c675
Autor:
Takeharu Sakamoto, Yuya Fukui, Yasumitsu Kondoh, Kaori Honda, Takeshi Shimizu, Toshiro Hara, Tetsuro Hayashi, Yurika Saitoh, Yoshinori Murakami, Jun-ichiro Inoue, Shuichi Kaneko, Hiroyuki Osada, Motoharu Seiki
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Sakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine productio
Externí odkaz:
https://doaj.org/article/19aa786f0153417ab843292a86a3abc2
Autor:
Ken Miyazawa, Yuichiro Asano, Masako Tabuchi, Shunsuke Kako, Makoto Kawatani, Hiroyuki Osada, Hatsuhiko Maeda, Shigemi Goto
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 40-47 (2021)
ReveromycinA (RMA) was developed and is a unique agent for inhibiting osteoclast activity. In a previous study, we experimentally induced periodontal disease in a high-turnover osteoporosis osteoprotegerin-knockout mice (OPG KO) model and found that
Externí odkaz:
https://doaj.org/article/f22f5ff9a1c0483ba2416cad9788ebca
Autor:
Marco Bürger, Kaori Honda, Yasumitsu Kondoh, Sharon Hong, Nobumoto Watanabe, Hiroyuki Osada, Joanne Chory
Publikováno v:
Plant Direct, Vol 6, Iss 9, Pp n/a-n/a (2022)
Abstract In Arabidopsis thaliana, the Sigma factor B regulator RsbQ‐like family of α/β hydrolases contains the strigolactone (SL) receptor DWARF14 (AtD14), the karrikin receptor KARRIKIN INSENSITIVE2 (AtKAI2), and DWARF14‐LIKE2 (AtDLK2), a prot
Externí odkaz:
https://doaj.org/article/6da91d96f036469f898b9ff71a932299