Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Hiroyuki Nakahira"'
Autor:
Tomoko Horisawa, Kumiko Tokuda, Osamu Ichikawa, Kazuhiko Okazaki, Hiroyuki Nakahira, Kazuto Yamazaki, Megumi Maruyama, Ryu Nagata
Publikováno v:
Neurochemistry International. 61:1133-1143
Lurasidone is a novel antipsychotic agent with high affinity for dopamine D(2), 5-hydroxyltryptamine 5-HT(2A), and 5-HT(7) receptors. Lurasidone has negligible affinity for histamine H(1) and muscarinic M(1) receptors, which are thought to contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e167b39123352b2e47c94d2c8dc8a1c1
https://doi.org/10.1016/j.neuint.2012.08.005
https://doi.org/10.1016/j.neuint.2012.08.005
Autor:
Hiroyuki Nakahira, Yohei Ikuma
Publikováno v:
Tetrahedron. 67:9509-9517
Representatives of the 3H-imidazo[4,5-c]quinolin-4(5H)-ones have shown interesting biological activity. We have found 2-aminosubstituted 3H-imidazo[4,5-c]quinolin-4(5H)-one as a potent dipeptidyl peptidase 4 inhibitor. However effective synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f7ee3e72550ede5b6914f426f32af5f
https://doi.org/10.1016/j.tet.2011.10.015
https://doi.org/10.1016/j.tet.2011.10.015
Autor:
Yudai Furuta, Tsutomu Nakagawa, Yukihiro Nishio, Mutsuko Sakai, Jiro Deguchi, Misato Otani, Takahiko Hashizuka, Eiji Sugaru, Hiroyuki Nakahira, Yumi Masui, Hidenori Kimura, Naoyuki Sawada, Michiko Ono, Yayoi Honda, Masakuni Horiguchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5490-5499
We report on the identification of 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727) (7a) as a potent and orally active DPP-4 inhibitor wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f143b36dd676e5163988e821e7d8534
https://doi.org/10.1016/j.bmc.2011.07.042
https://doi.org/10.1016/j.bmc.2011.07.042
Publikováno v:
Tetrahedron Letters. 52:2767-2770
One-pot synthesis of 5-amino 4-cyano pyrrole derivatives is herein disclosed. The described method consists of four steps and gives new pyrrole derivatives in moderate to good yields. This synthesis can be used for a large scale preparation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8e0893f7a7c8f55909608f7e3e9b0e
https://doi.org/10.1016/j.tetlet.2011.03.080
https://doi.org/10.1016/j.tetlet.2011.03.080
Publikováno v:
Tetrahedron. 67:3124-3131
Optimization details and limitations of a novel synthetic method of 4-tert-butyl 2-ethyl 3-amino-1-benzyl-5-dialkylamino-1H-pyrrole-2,4-dicarboxylate derivatives are herein disclosed. This synthesis consists of four steps that include a highly select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8e3239d2d9c952d3b07c3998c400b0
https://doi.org/10.1016/j.tet.2011.02.071
https://doi.org/10.1016/j.tet.2011.02.071
Autor:
Hiroyuki Nakahira, Yukihiro Nishio, Mutsuko Sakai, Michiko Ono, Shinya Tosaki, Eiji Sugaru, Masakuni Horiguchi, Hidenori Kimura, Tsutomu Nakagawa, Yumi Masui
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7246-7249
Structures containing the (R)-3-amino-3-methyl piperidine unit as a new pharmacophore moiety have been shown to possess moderate inhibitory activity for DPP-4 with good pharmacokinetics profile. One of these compounds was found to have good oral bioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0754dc268cbfd798fb76bb8881582b26
https://doi.org/10.1016/j.bmcl.2010.10.101
https://doi.org/10.1016/j.bmcl.2010.10.101
Autor:
Yasuhiro Sato, Masakuni Horiguchi, M. Otani, Mutsuo Taiji, Yumi Masui, Mutsuko Sakai, Hitoshi Hochigai, K. Takubo, Hidenori Kimura, Tsutomu Nakagawa, Atsushi Tsuchida, Hiroyuki Nakahira, Michiko Ono-Kishino, Eiji Sugaru, Yudai Furuta
Publikováno v:
Diabetes, Obesity and Metabolism. 12:421-430
Aims The purpose of this study is to assess the in vitro enzyme inhibition profile of DSP-7238, a novel non-cyanopyrrolidine dipeptidyl peptidase (DPP) IV inhibitor and to evaluate the acute and chronic effects of this compound on glucose metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54ab27497c7099671677dd36951ab27
https://doi.org/10.1111/j.1463-1326.2009.01180.x
https://doi.org/10.1111/j.1463-1326.2009.01180.x
Autor:
Kouji Okamoto, Yoshinori Shirakawa, Kouichi Nagano, Akira Yamamoto, Hiroki Mouri, Takashi Yamamoto, Hiroyuki Nakahira
Publikováno v:
Japanese Journal of Applied Physics. 47:5848-5852
We propose a read-channel system with quasi-synchronous sampling and an adaptive partial-response maximum-likelihood (PRML) method to achieve accurate timing recovery and correct data extraction under high-density recording with a high transfer rate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b430ecc39c2d7c6e8eea13e6a3bc5af
https://doi.org/10.1143/jjap.47.5848
https://doi.org/10.1143/jjap.47.5848
Autor:
Tomonori Kobayashi, Hiroyuki Nakahira, Katsuya Uchiyama, Takashi Umezome, Yohei Ikuma, Eiji Sugaru, Hidenori Kimura, Yuko Hirose, Hitoshi Hochigai, Naoyuki Sawada, Michiko Ono, Noriko Nunami, Jun Tadano, Yasumitsu Sakurai
Publikováno v:
Bioorganicmedicinal chemistry. 23(4)
We have previously reported a novel series of 3H-imidazo[4,5-c]quinolin-4(5H)-ones with potent dipeptidyl peptidase IV (DPP-4) inhibitory activity. However, these compounds showed poor oral absorption. We attempted in this study esterification of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e51265faa7bb55b973e8f493c32c3e9
https://pubmed.ncbi.nlm.nih.gov/25596166
https://pubmed.ncbi.nlm.nih.gov/25596166
Autor:
Yudai Furuta, Hidenori Kimura, Hitoshi Hochigai, Tomonori Kobayashi, Kazuhiko Okazaki, Noriko Nunami, Yohei Ikuma, Hiroyuki Nakahira, Katsuya Uchiyama, Masakuni Horiguchi, Yasuhiro Sato, Yumi Masui, Mutsuko Sakai
Publikováno v:
Bioorganicmedicinal chemistry. 20(19)
In recent years, dipeptidyl peptidase IV inhibitors have been noted as valuable agents for treatment of type 2 diabetes. Herein, we report the discovery of a novel potent DPP-4 inhibitor with 3H-imidazo[4,5-c]quinolin-4(5H)-one as skeleton. After eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e07d3fbddfed82a2b1a5cfefcc859b
https://pubmed.ncbi.nlm.nih.gov/22938786
https://pubmed.ncbi.nlm.nih.gov/22938786