Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Hiroyuki Miyachi"'
Autor:
Hiroyuki Miyachi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3940 (2023)
Recent progress in the structural and molecular pharmacological understanding of the nuclear receptor, peroxisome proliferator-activated receptor gamma (hPPARγ)—a transcription factor with pleiotropic effects on biological responses—has enabled
Externí odkaz:
https://doaj.org/article/5a75e9b22812426d994a49e28d057bd7
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 4, Pp 264-271 (2020)
Fatty acid-binding proteins (FABPs) belong to a family of proteins that transports fatty acids in the cytosol and regulates cellular functions like membrane phospholipid synthesis, lipid metabolism, and mitochondrial β oxidation. In this study, we s
Externí odkaz:
https://doaj.org/article/ee50e216b51d44ca88804ff921a09e02
Autor:
Hiroyuki Miyachi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9223 (2021)
Progress in understanding peroxisome proliferator-activated receptor (PPAR) subtypes as nuclear receptors that have pleiotropic effects on biological responses has enabled the exploration of new subtype-selective PPAR ligands. Such ligands are useful
Externí odkaz:
https://doaj.org/article/986a837ee422492b9fe056e4c89fa662
Autor:
Rehana Parvin, Erika Noro, Akiko Saito-Hakoda, Hiroki Shimada, Susumu Suzuki, Kyoko Shimizu, Hiroyuki Miyachi, Atsushi Yokoyama, Akira Sugawara
Publikováno v:
PPAR Research, Vol 2018 (2018)
Although therapeutic effects of the peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists rosiglitazone and pioglitazone against Cushing’s disease have been reported, their effects are still controversial and inconsistent. We therefor
Externí odkaz:
https://doaj.org/article/6de8fcced2d142a3a7a51badca5df7f1
Publikováno v:
PPAR Research, Vol 2011 (2011)
Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs). It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice. Therefore, it is
Externí odkaz:
https://doaj.org/article/19810781db8f4b43832304a9f7da927d
Autor:
Shaoteng Han, Takuya Fukazawa, Tomoki Yamatsuji, Junji Matsuoka, Hiroyuki Miyachi, Yutaka Maeda, Mary Durbin, Yoshio Naomoto
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13834 (2010)
Histone deacetylase (HDAC) inhibitors arrest cancer cell growth and cause apoptosis with low toxicity thereby constituting a promising treatment for cancer. In this study, we investigated the anti-tumor activity in lung cancer cells of the novel cycl
Externí odkaz:
https://doaj.org/article/ba686ad417b34bc3a3819e2056a5819c
Autor:
Hiroyuki Miyachi, Yuichi Hashimoto
Publikováno v:
PPAR Research, Vol 2008 (2008)
Improvements in our understanding of the functions of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) subtypes as pleiotropic regulators of biological responses, including lipid, lipoprotein, glucose homeostasis, inflammation,
Externí odkaz:
https://doaj.org/article/ee3e2fc52bcc45f8948772babfc0944f
Autor:
Hiroyuki Miyachi
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(12)
Nuclear receptors are ligand-dependent transcription factors that act as signal transducers by binding to and regulating the transcription of target DNA (genomic action). In recent years, nuclear receptors have also been found to exhibit a direct act
Autor:
Shota Takeda, Hiroyuki Miyachi, Yukiko Mizumoto, Osamu Takikawa, Akira Asai, Miyuki Kumazawa, Kenji Matsuno, Minoru Waki, Miwa Fukuda, Osamu Ohno, Tomoko Hashimoto, Manabu Tejima, Kakeru Sato, Kenji Suzuki
Publikováno v:
ACS Med Chem Lett
[Image: see text] A structure–activity relationship study unexpectedly showed that carbonothioates 4a and 4b, obtained by a unique alkaline hydrolysis of 2-alkylthio-oxazolines 3a and 3b, respectively, are a novel scaffold for indoleamine 2,3-dioxy
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 4, Pp 264-271 (2020)
Fatty acid-binding proteins (FABPs) belong to a family of proteins that transports fatty acids in the cytosol and regulates cellular functions like membrane phospholipid synthesis, lipid metabolism, and mitochondrial β oxidation. In this study, we s