Výsledky vyhledávání - "Hiroyuki Matsumura"

Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles

Autor: Sotaro Kurata, Hironobu Morinaga, Shigeo Ohno, Shizuko Ichinose, Nan Liu, Yasuaki Mohri, Daisuke Nanba, Adèle De Arcangelis, Emi K. Nishimura, Aki Takada, Hiroyuki Matsumura

Publikováno v: Nature Aging. 1:190-204

Hair follicles, mammalian mini-organs that grow hair, miniaturize during aging, leading to hair thinning and loss. Here we report that hair follicle stem cells (HFSCs) lose their regenerative capabilities during aging owing to the adoption of an atyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1ae52d5af523b98ac5b0d2be403f755
https://doi.org/10.1038/s43587-021-00033-7

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NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP

Autor: Hind Al-Busani, Atsushi Tanemura, Hiroyuki Matsumura, Kohei Nojima, Saber Al-Sobaihi, Takeshi Namiki, Yutaka Kawakami, Tomonori Yaguchi, Emi K. Nishimura, Hiroo Yokozeki

Publikováno v: Journal of Dermatological Science. 97:143-151

Background NUAK2 is a critical gene that participates in the carcinogenesis of various types of cancers including melanomas. However, the expression patterns of NUAK2 in normal skin and in various types of skin tumors have not been fully elucidated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6758514fbd13aadbc21f387c5a9d5848
https://doi.org/10.1016/j.jdermsci.2020.01.008

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EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis

Autor: Daisuke Nanba, Koji Sayama, Hiroyuki Matsumura, Kyosuke Asakawa, Fujio Toki, Emi K. Nishimura, Kyoichi Matsuzaki, Hiroshi Toki, Ken Shiraishi

Publikováno v: Journal of Cell Biology. 220

Skin regenerative capacity declines with age, but the underlying mechanisms are largely unknown. Here we demonstrate a functional link between epidermal growth factor receptor (EGFR) signaling and type XVII collagen (COL17A1) proteolysis on age-assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431dc89c6032956b3c6f9d48f64bbaa7
https://doi.org/10.1083/jcb.202012073

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Stem cell competition orchestrates skin homeostasis and ageing

Autor: Hiroyuki Matsumura, Adèle De Arcangelis, Emi K. Nishimura, Aki Takada, Tomoki Kato, Daisuke Nanba, Hironobu Morinaga, Kyosuke Asakawa, Shizuko Ichinose, Takeshi Namiki, Elisabeth Geroges-Labouesse, Nan Liu, Yasuaki Mohri

Publikováno v: Nature. 568:344-350

Stem cells underlie tissue homeostasis, but their dynamics during ageing—and the relevance of these dynamics to organ ageing—remain unknown. Here we report that the expression of the hemidesmosome component collagen XVII (COL17A1) by epidermal st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a79db9120f9dcd4f46d3e4ab0365049d
https://doi.org/10.1038/s41586-019-1085-7

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Dynamic stem cell selection safeguards the genomic integrity of the epidermis

Autor: Tomoki Kato, Nan Liu, Hironobu Morinaga, Kyosuke Asakawa, Taichi Muraguchi, Yuko Muroyama, Mariko Shimokawa, Hiroyuki Matsumura, Yuriko Nishimori, Li Jing Tan, Motoshi Hayano, David A. Sinclair, Yasuaki Mohri, Emi K. Nishimura

Publikováno v: Developmental cell. 56(24)

Maintaining genomic integrity and stability is crucial for life; yet, no tissue-driven mechanism that robustly safeguards the epithelial genome has been discovered. Epidermal stem cells (EpiSCs) continuously replenish the stratified layers of keratin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781fd072e0b062b561b285ab9b1b96c9
https://pubmed.ncbi.nlm.nih.gov/34932945

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