Výsledky vyhledávání - "Hiroyuki Kyushiki"

Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts

Autor: Noriaki Ikemoto, Takeshi Suetomi, Wakako Murakami, Masahiro Doi, Masafumi Yano, Noritaka Koseki, Takehisa Susa, Masakazu Fukuda, Shinichi Okuda, Hiroyuki Kyushiki, Akihiro Hino, Shigeki Kobayashi, Makoto Ono, Masunori Matsuzaki, Takayoshi Kato, Takeshi Yamamoto

Publikováno v: Cardiovascular Research. 96:433-443

Aims The channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, the involvement of CaM in aberrant Ca2+ release in diseased hearts remains unclear. Here, we investigated the pathogenic role of defective C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c214192a1063ad2a63e07061a65ff01
https://doi.org/10.1093/cvr/cvs271

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Identification of the active region responsible for the anti-thrombotic activity of anopheline anti-platelet protein from a malaria vector mosquito

Autor: Hideki Hayashi, Toshiki Sudo, Hiroyuki Matsuoka, Hiroyuki Kyushiki, Mitsuhiro Iyori, Keisuke Nagano, Shigeto Yoshida

Publikováno v: Platelets. 24:324-332

We previously identified an anti-platelet protein, anopheline anti-platelet protein (AAPP), from the salivary gland of female Anopheles stephensi (a mosquito vector of human malaria). AAPP specifically blocks platelet adhesion to collagen by binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81800c4cc35b8618d9c2e67e685ebbe2
https://doi.org/10.3109/09537104.2012.698430

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Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice

Autor: Satoshi Takeda, Masashi Niimi, Keiji Okuyama, Norihiro Miyazawa, Yasuhide Mitsumoto, Hiroyuki Kyushiki, Naoki Nishino, Mari Kondo, Yoshikazu Shimada, Yoshihiro Taniguchi, Takashi Wadatsu, Masato Horie, Atsushi Mori

Publikováno v: Neuroscience Research. 43:251-257

Mint-1, which is also called as X11 or mammalian Lin10, protein has been implicated in the synaptic vesicle exocytosis and the targeting and localization of synaptic membrane proteins. Here, we established mint-1 gene knockout (mint-1 KO) mice and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ac0bc3792303f6f73b24c49880af7d
https://doi.org/10.1016/s0168-0102(02)00041-x

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Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes

Autor: Shinichi Okuda, Hiroyuki Kyushiki, Makoto Ono, Hiroki Tateishi, Masakazu Fukuda, Akihiro Hino, Wakako Murakami, Masafumi Yano, Shigeki Kobayashi, Noritaka Koseki, Takayoshi Kato, Takeshi Yamamoto, Shigehiko Nishimura, Testuro Oda

Publikováno v: Biochemical and biophysical research communications. 448(1)

Aims Calmodulin (CaM) plays a key role in modulating channel gating in ryanodine receptor (RyR2). Here, we investigated (a) the pathogenic role of CaM in the channel disorder in CPVT and (b) the possibility of correcting the CPVT-linked channel disor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180fb4eaed34091146cb9f56274b4dc7
https://pubmed.ncbi.nlm.nih.gov/24755079

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Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle

Autor: Toshimi Kambe, Takeshi Ogawara, Hiroyuki Kyushiki, Takashi Ban, Yasuchika Yamamoto, Atsunori Ueyama, Hiroyuki Fukui, Akira Tanigami, Tsutomu Fujiwara, Tatsuya Yamashita, Masashi Niimi, Kouichi Ozaki, Ei-ichi Takahashi, Hidenori Tamanoi, Takashi Okamoto

Publikováno v: Journal of Human Genetics. 46:566-571

Glutamine:fructose-6-phosphate amidotransferase (GFAT1) is the rate-limiting enzyme in the hexosamine biosynthetic pathway, which plays an important role in hyperglycemia-induced insulin resistance. To evaluate the role of GFAT1 expression, we analyz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580c4d0fa3bff8c2577985ecc54b5ef7
https://doi.org/10.1007/s100380170022

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Identification and Characterization of TMEFF2, a Novel Survival Factor for Hippocampal and Mesencephalic Neurons

Autor: Yusuke Nakamura, Toyoki Mori, Yoshihiro Taniguchi, Akira Tanigami, Masato Horie, Naohide Kanemoto, Akihito Watanabe, Naoki Nishino, Mari Kondo, Takashi Okamoto, Ei-ichi Takahashi, Hiroyuki Kyushiki, Yasuhide Mitsumoto, Koichi Noguchi

Publikováno v: Genomics. 67:146-152

We have identified a novel mammalian gene, TMEFF2, that encodes a putative transmembrane protein containing two follistatin-like domains and one epidermal growth factor (EGF)-like domain. The TMEFF2 gene is predominantly expressed in the brain. In si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b176d52d559e2bff04df48564ad70e39
https://doi.org/10.1006/geno.2000.6228

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Alterations of the Cytoskeletal Organization in Tumor Cell Lines by a Cardiotonic Drug, Vesnarinone, through Protein Tyrosine Phosphorylation

Autor: Yoshiyuki Yoshinaka, Hiroyuki Kyushiki, Iyoko Katoh, Yoko Sakamoto

Publikováno v: Experimental Cell Research. 219:21-28

We describe nonspecific and moderate activation of cellular protein tyrosine phosphorylation by a chemical compound, vesnarinone, which results in enhanced synthesis and/or assembly of cytoskeletal proteins and morphological alterations in several tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4657c69acc1b27ad498d08ed59bc53ca
https://doi.org/10.1006/excr.1995.1200

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Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure

Autor: Hitoshi Uchinoumi, Takehisa Susa, Shigeki Kobayashi, Noriaki Ikemoto, Takeshi Suetomi, Takeshi Yamamoto, Noritaka Koseki, Masahiro Doi, Akihiro Hino, Hiroki Tateishi, Tetsuro Oda, Xiaojuan Xu, Masafumi Yano, Shinichi Okuda, Hiroyuki Kyushiki, Makoto Ono, Masunori Matsuzaki

Publikováno v: Cardiovascular research. 87(4)

Aims Calmodulin (CaM) is well known to modulate the channel function of the cardiac ryanodine receptor (RyR2). However, the possible role of CaM on the aberrant Ca2+ release in diseased hearts remains unclear. In this study, we investigated the state

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9898b6593682f331c0bf8d112cb1dbf
https://pubmed.ncbi.nlm.nih.gov/20587508

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