Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Hiroyuki Kumeta"'
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102996- (2024)
Summary: Mincle (macrophage-inducible C-type lectin, CLEC4E) is a C-type lectin immune-stimulatory receptor that can be targeted for inducing potent adjuvant effects. Mincle can recognize trehalose dimycolate and related glycolipids. Here, we present
Externí odkaz:
https://doaj.org/article/91eb0ce979b24c448a0af611d1b26160
Autor:
Lareno L. Villones, Anna-Kristin Ludwig, Hiroyuki Kumeta, Seiya Kikuchi, Rika Ochi, Tomoyasu Aizawa, Shin-Ichiro Nishimura, Hans-Joachim Gabius, Hiroshi Hinou
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Dystroglycan (DG), which constitutes a part of the dystrophin–glycoprotein complex, connects the extracellular matrix to the cytoskeleton. The matriglycans presented by the extracellular α-DG serve as a contact point with extracellular ma
Externí odkaz:
https://doaj.org/article/3b313ae12f4c4ebbae078d91bb584ce4
Autor:
Kazuma Kishi, Masaki Kuwatani, Yuki Ohnishi, Yasuhiro Kumaki, Hiroyuki Kumeta, Hajime Hirata, Yunosuke Takishin, Ryutaro Furukawa, Kosuke Nagai, Hiroki Yonemura, Shunichiro Nozawa, Ryo Sugiura, Kazumichi Kawakubo, Tomoyasu Aizawa, Naoya Sakamoto
Publikováno v:
Cancers, Vol 15, Iss 17, p 4370 (2023)
The poor prognosis of malignant biliary diseases is partially caused by their difficult early diagnosis. Therefore, many patients are only diagnosed at advanced stages. This study aimed to improve diagnosis by clarifying the differences in the duoden
Externí odkaz:
https://doaj.org/article/14c9aed1dbe34f5e94c5e33a543a3e4d
Autor:
Zihao Song, Yuki Ohnishi, Seiji Osada, Li Gan, Jiaxi Jiang, Zhiyan Hu, Hiroyuki Kumeta, Yasuhiro Kumaki, Yuki Yokoi, Kiminori Nakamura, Tokiyoshi Ayabe, Kazuo Yamauchi, Tomoyasu Aizawa
Publikováno v:
Metabolites, Vol 13, Iss 5, p 611 (2023)
Nuclear magnetic resonance (NMR)-based metabolomics, which comprehensively measures metabolites in biological systems and investigates their response to various perturbations, is widely used in research to identify biomarkers and investigate the path
Externí odkaz:
https://doaj.org/article/bf624b2ec55645f683f74859aa234358
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Although fish is an important part of the human diet, it is also a common source of food allergy. The major allergen in fish is parvalbumin, a well-conserved Ca2+-binding protein found in the white muscle of many fish species. Here, we studi
Externí odkaz:
https://doaj.org/article/509fb3e6bfff4ba0852209bf3ff83bf0
Autor:
Akinori Yamasaki, Yasunori Watanabe, Wakana Adachi, Kuninori Suzuki, Kazuaki Matoba, Hiromi Kirisako, Hiroyuki Kumeta, Hitoshi Nakatogawa, Yoshinori Ohsumi, Fuyuhiko Inagaki, Nobuo N. Noda
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 19-27 (2016)
Selective autophagy mediates the degradation of various cargoes, including protein aggregates and organelles, thereby contributing to cellular homeostasis. Cargo receptors ensure selectivity by tethering specific cargo to lipidated Atg8 at the isolat
Externí odkaz:
https://doaj.org/article/2145ef6370a34e13b22cd5456ff4702c
Autor:
Natsuki Fukuda, Kentaro Noi, Lidong Weng, Yoshihiro Kobashigawa, Hiromi Miyazaki, Yukari Wakeyama, Michiyo Takaki, Yusuke Nakahara, Yuka Tatsuno, Makiyo Uchida-Kamekura, Yoshiaki Suwa, Takashi Sato, Naoki Ichikawa-Tomikawa, Motoyoshi Nomizu, Yukio Fujiwara, Fumina Ohsaka, Takashi Saitoh, Katsumi Maenaka, Hiroyuki Kumeta, Shoko Shinya, Chojiro Kojima, Teru Ogura, Hiroshi Morioka
Publikováno v:
Molecules, Vol 22, Iss 10, p 1695 (2017)
Due to their lower production cost compared with monoclonal antibodies, single-chain variable fragments (scFvs) have potential for use in several applications, such as for diagnosis and treatment of a range of diseases, and as sensor elements. Howeve
Externí odkaz:
https://doaj.org/article/ec91204768074e62bae41965348e2ac8
Autor:
Koki Suzuki, Ryoya Nojiri, Motonori Matsusaki, Takuya Mabuchi, Shingo Kanemura, Kotone Ishii, Hiroyuki Kumeta, Masaki Okumura, Tomohide Saio, Takahiro Muraoka
Publikováno v:
Chemical Science; 8/28/2024, Vol. 15 Issue 32, p12676-12685, 10p
Autor:
Soichiro Kawagoe, Munehiro Kumashiro, Takuya Mabuchi, Hiroyuki Kumeta, Koichiro Ishimori, Tomohide Saio
Publikováno v:
Biochemistry. 61:2897-2908
A transcriptional regulatory system called heat shock response (HSR) has been developed in eukaryotic cells to maintain proteome homeostasis under various stresses. Heat shock factor-1 (Hsf1) plays a central role in HSR, mainly by upregulating molecu
Autor:
Hiroshi Nakagawa, Mizue Asada, Koichiro Ishimori, Kazumi Shimizu, Tomohide Saio, Toshikazu Nakamura, Soya Hiramatsu, Hiroyuki Kumeta
Publikováno v:
Biophysical journal. 120(15):2943-2951
Despite their importance in function, the conformational state of proteins and its changes are often poorly understood, mainly because of the lack of an efficient tool. MurD, a 47-kDa protein enzyme responsible for peptidoglycan biosynthesis, is one