Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Hiroyuki Kubota"'
Autor:
Hideki Maehara, Toshiya Kokaji, Atsushi Hatano, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Riku Egami, Takaho Tsuchiya, Haruka Ozaki, Keigo Morita, Masaki Shirai, Dongzi Li, Akira Terakawa, Saori Uematsu, Ken-ichi Hironaka, Satoshi Ohno, Hiroyuki Kubota, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Shinya Kuroda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein production. However, the coordination
Externí odkaz:
https://doaj.org/article/98436c9b09ae438fad492d1943038991
Autor:
Yuki Ito, Shinsuke Uda, Toshiya Kokaji, Akiyoshi Hirayama, Tomoyoshi Soga, Yutaka Suzuki, Shinya Kuroda, Hiroyuki Kubota
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Interactions between various molecular species in biological phenomena give rise to numerous networks. The investigation of these networks, including their statistical and biochemical interactions, supports a deeper understanding of biologic
Externí odkaz:
https://doaj.org/article/d49e627e1b084f6791576e488423b87c
Autor:
Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, Yunfan Bai, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Hiroyuki Kubota, Yutaka Suzuki, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Metabolic regulation in skeletal muscle is essential for blood glucose homeostasis. Obesity causes insulin resistance in skeletal muscle, leading to hyperglycemia and type 2 diabetes. In this study, we performed multiomic analysis of the ske
Externí odkaz:
https://doaj.org/article/dd5db8b9f47843dbacf9bbaaf001a016
Autor:
Suguru Fujita, Yasuaki Karasawa, Masashi Fujii, Ken-ichi Hironaka, Shinsuke Uda, Hiroyuki Kubota, Hiroshi Inoue, Yohei Sumitomo, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the conce
Externí odkaz:
https://doaj.org/article/ed535d8abeef4ca8a00569199c403e62
Autor:
Saori Uematsu, Satoshi Ohno, Kaori Y. Tanaka, Atsushi Hatano, Toshiya Kokaji, Yuki Ito, Hiroyuki Kubota, Ken-ichi Hironaka, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103787- (2022)
Summary: Glucose homeostasis is maintained by modulation of metabolic flux. Enzymes and metabolites regulate the involved metabolic pathways. Dysregulation of glucose homeostasis is a pathological event in obesity. Analyzing metabolic pathways and th
Externí odkaz:
https://doaj.org/article/45123136428f459f9e3a0b9ac88e2a87
Autor:
Fumiko Matsuzaki, Shinsuke Uda, Yukiyo Yamauchi, Masaki Matsumoto, Tomoyoshi Soga, Kazumitsu Maehara, Yasuyuki Ohkawa, Keiichi I. Nakayama, Shinya Kuroda, Hiroyuki Kubota
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109569- (2021)
Summary: An effective combination of multi-omic datasets can enhance our understanding of complex biological phenomena. To build a context-dependent network with multiple omic layers, i.e., a trans-omic network, we perform phosphoproteomics, transcri
Externí odkaz:
https://doaj.org/article/bda0cb6d08e645f0b537c16d4a675d84
Autor:
Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Saori Uematsu, Akira Terakawa, Yunfan Bai, Yifei Pan, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102217- (2021)
Summary: Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic diseases. The systemic landscape of dysregulated inter-organ metaboli
Externí odkaz:
https://doaj.org/article/16277b1822a647cf9a657d68049c4b26
Autor:
Kentaro Kawata, Atsushi Hatano, Katsuyuki Yugi, Hiroyuki Kubota, Takanori Sano, Masashi Fujii, Yoko Tomizawa, Toshiya Kokaji, Kaori Y. Tanaka, Shinsuke Uda, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Kaori Saitoh, Keiko Kato, Ayano Ueno, Maki Ohishi, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 7, Iss , Pp 212-229 (2018)
Summary: The concentrations of insulin selectively regulate multiple cellular functions. To understand how insulin concentrations are interpreted by cells, we constructed a trans-omic network of insulin action in FAO hepatoma cells using transcriptom
Externí odkaz:
https://doaj.org/article/298b57f6bf194eb08a0765046fd90937
Autor:
Shinsuke Uda, Hiroyuki Kubota
Publikováno v:
Proceedings of the XXth Conference of Open Innovations Association FRUCT, Vol 562, Iss 21, Pp 336-343 (2017)
Recent advances in measurement technology have enabled us to measure various omic layers, such as genome, transcriptome, proteome, and metabolome layers. The demand for data analysis to determine the network structure of the interaction between molec
Externí odkaz:
https://doaj.org/article/4997c7ae11c44228bdf5be1687b18861
Autor:
Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2901-2916.e6 (2019)
Summary: The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighte
Externí odkaz:
https://doaj.org/article/3130a74898634135897cc8dbe1421653