Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hiroyuki Kouji"'
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract In cells, mRNA synthesis and decay are influenced by each other, and their balance is altered by either external or internal cues, resulting in changes in cell dynamics. We previously reported that it is important that an array of mRNAs that
Externí odkaz:
https://doaj.org/article/b3d2d7b628694a60b7c3615394eae4ac
Autor:
Yasunobu Asawa, Saki Hatsuzawa, Atsushi Yoshimori, Kentaro Yamada, Akira Katoh, Hiroyuki Kouji, Hiroyuki Nakamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract A total of 42 trisubstituted carboranes categorised into five scaffolds were systematically designed and synthesized by exploiting the different reactivities of the twelve vertices of o-, m-, and p-carboranes to cover all directions in chemi
Externí odkaz:
https://doaj.org/article/5bfb1398b2014dceb687354cb4b37d37
Autor:
Tomomitsu Doi, Hironori Hojo, Shinsuke Ohba, Kunie Obayashi, Motoyoshi Endo, Toshimasa Ishizaki, Akira Katoh, Hiroyuki Kouji
Publikováno v:
Heliyon, Vol 8, Iss 2, Pp e08890- (2022)
Wnt/β-catenin is believed to regulate different sets of genes with different coactivators, cAMP response element-binding protein (CREB)-binding protein (CBP) or p300. However, the factors that determine which coactivators act on a particular promote
Externí odkaz:
https://doaj.org/article/0a9a552227084252ba640f08a91f5346
Publikováno v:
F1000Research, Vol 4 (2015)
In a previous Method Article, we have presented the ‘Structure-Activity Relationship (SAR) Matrix’ (SARM) approach. The SARM methodology is designed to systematically extract structurally related compound series from screening or chemical optimiz
Externí odkaz:
https://doaj.org/article/104ede2454054addaf01324d0883ad0a
Autor:
Kohei, Umedera, Atsushi, Yoshimori, Hengwei, Chen, Hiroyuki, Kouji, Hiroyuki, Nakamura, Jürgen, Bajorath
Publikováno v:
Journal of Computer-Aided Molecular Design. 37:107-115
Mimicking bioactive conformations of peptide segments involved in the formation of protein-protein interfaces with small molecules is thought to represent a promising strategy for the design of protein-protein interaction (PPI) inhibitors. For compou
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
The list of Topologically significant genes by RNA-Seq analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b281375c38e0afca97059249be1c48
https://doi.org/10.1158/0008-5472.22427412
https://doi.org/10.1158/0008-5472.22427412
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and the development of multiple types of cancer, and its aberrant activation provides cancer cells with escape mechanisms from immune checkpoint inhibitors. E7386, an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df148bb84b7d866ede93b24adb73553f
https://doi.org/10.1158/0008-5472.c.6512661.v1
https://doi.org/10.1158/0008-5472.c.6512661.v1
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
Supplementary Table S1, Table S4, Table S5, Table S6, Table S7. Supplementary Table S1: The list of DEGs by nCounter analysis (|Fold change| > 1.25, P < 0.1). Supplementary Table S4: Top 10 enriched pathways identified by RNA-Seq analysis in MMTV-Wnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f3891dd6ecfe611c8e93caa46647a9
https://doi.org/10.1158/0008-5472.22427409
https://doi.org/10.1158/0008-5472.22427409
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837e71997bd46c4dda72ece16272f5ee
https://doi.org/10.1158/0008-5472.22427418.v1
https://doi.org/10.1158/0008-5472.22427418.v1
Autor:
Takeo Nakaya, Kenichi Aizawa, Yuki Taguchi, Kentaro Tsuji, Sachi Sekine, Kazuhiro Murakami, Masaji Kasai, Hirofumi Nakano, Yasumitsu Kondoh, Shingo Dan, Atsushi Yoshimori, Hiroyuki Kouji, Dai Takehara, Toru Suzuki, Hiroyuki Osada, Masayuki Murata, Akira Tanaka, Ryozo Nagai
Publikováno v:
ACS Med Chem Lett
[Image: see text] Krüppel-like factor 5 (KLF5) is a potential target for anticancer drugs. However, as an intrinsically disordered protein (IDP) whose tertiary structure cannot be solved, innovative strategies are needed. We focused on its hydrophob