Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hiroyuki Komazawa"'
Autor:
Masayoshi Kojima, Aya Obata, Ikuo Saiki, Koichi Ayukawa, Hiroyuki Komazawa, Makoto Suzuki, Hideki Fujii, Ichiro Azuma, Naoyuki Nishikawa, Isamu Itoh
Publikováno v:
Clinical and Experimental Metastasis. 16:94-104
A series of pseudo-peptide analogs of the Arg-Gly-Asp (RGD) sequence of fibronectin have been synthesized, and their anti-metastatic effects in mice and inhibitory effects on tumor cell invasion in vitro have been examined. The partially modified ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4357d091da3ae697c0a38c659bc3b1b8
https://doi.org/10.1023/a:1006520220426
https://doi.org/10.1023/a:1006520220426
Autor:
Naoyuki Nishikawa, Atsushi Orikasa, Mitsunori Ono, Jun Murata, Mitsuo Yoshikane, Hiroyuki Komazawa, Hideki Fujii, Isamu Itoh, Jiro Yamaguchi, Masayoshi Kojima, Ichiro Azuma, Ikuo Saiki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2725-2728
Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects of experimental lung metastasis of murine melanoma and adenosine 5′-diphosphate (ADP) induced platelet aggregatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa76bd4a099f3730791c0beccdbe18cb
https://doi.org/10.1016/s0960-894x(96)00494-5
https://doi.org/10.1016/s0960-894x(96)00494-5
Autor:
Hiroyuki Komazawa, Ichiro Azuma, Ikuo Saiki, Hideto Mori, Jun Murata, Isamu Itoh, Masayoshi Kojima, Hideki Fujii
Publikováno v:
Biological and Pharmaceutical Bulletin. 18:1681-1688
We have investigated the inhibitory effect of the N-terminal modified Arg-Gly-Asp-Ser (RGDS) analogues, AcDRGDS and AcDRLDS, on tumor cell adhesion to the components of extracellular matrix and basement membrane, and also tested the antimetastatic ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6020f5dc9391ee2456e273276117e0
https://doi.org/10.1248/bpb.18.1681
https://doi.org/10.1248/bpb.18.1681
Autor:
Atsushi Orikasa, Masayoshi Kojima, Hiroyuki Komazawa, Mitsunori Ono, Isamu Itoh, Ikuo Saiki, Yu Igarashi, Ichiro Azuma
Publikováno v:
Journal of Bioactive and Compatible Polymers. 8:258-274
A water soluble polymer containing cell adhesive Arg-Gly-Asp- Ser (RGDS) sequence, i.e., poly(carboxyethylmethacrylamide-RGDS) conjugate [poly(CEMA-RGDS)], was synthesized. Poly(CEMA-RGDS) inhibited lung metastasis of B16-BL6 melanoma cells in a dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a02c88422382a1c5540907d324d9e8
https://doi.org/10.1177/088391159300800305
https://doi.org/10.1177/088391159300800305
Autor:
Ikuo Saiki, Junya Yoneda, Yu Igarashi, Hiroyuki Komazawa, Ichiro Azuma, Yukuo Ishizaki, Hideo Kobayashi, Ikunoshin Kato
Publikováno v:
Japanese Journal of Cancer Research : Gann
We have investigated the therapeutic effect of CH‐271 fusion polypeptide containing both cell‐binding domain (C‐274) and heparin‐binding domain (H‐271) of fibronectin in combination with anticancer drugs such as doxorubicin (DOX) or mitomyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20c29ac917a753d1948ef4486fe7c8c
https://doi.org/10.1111/j.1349-7006.1993.tb02874.x
https://doi.org/10.1111/j.1349-7006.1993.tb02874.x
Autor:
Mitsunori Ono, Ikuo Saiki, Miho Aoki, Isamu Itoh, Ichiro Azuma, Hiroyuki Komazawa, Masayoshi Kojima, Hideaki Satoh, Hiroshi Kitaguchi
Publikováno v:
Biological and Pharmaceutical Bulletin. 16:997-1003
Synthetic peptide analogues of the Arg-Gly-Asp-Ser(RGDS) sequence of fibronectin in which the amino acid of Gly was substituted with another one, named X, i.e. Arg-X-Asp-Ser (R-X-DS), and N-terminal modified R-X-DS have been synthesized to examine th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f940ea64a198fd5ccd219e67b379d0
https://doi.org/10.1248/bpb.16.997
https://doi.org/10.1248/bpb.16.997
Autor:
Hiroyuki Komazawa, Isamu Itoh, Ikuo Saiki, Atsushi Orikasa, Yu Igarashi, Ichiro Azuma, Masayoshi Kojima, Mitsunori Ono, Seiichi Tokura
Publikováno v:
Carbohydrate Polymers. 21:299-307
A water soluble 6- O -carboxymethyl chitin (CM-chitin) containing cell adhesive Arg-Gly-Asp-Ser (RGDS) sequence, i.e. CM-chitin-RGDS conjugate was synthesized, and the inhibitory effects of this compound on lung or liver metastasis of lung-metastatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1c2e3cfd4d4d2334301df63644a5396
https://doi.org/10.1016/0144-8617(93)90063-a
https://doi.org/10.1016/0144-8617(93)90063-a
Autor:
Hideo Tsukada, Ikuo Saiki, Jun Murata, Naoto Oku, Hideki Fujii, Shoji Okada, Makoto Kiso, Ichiro Azuma, Hiroyuki Komazawa, Aya Obata, Akira Hasegawa, Chieko Koike
Publikováno v:
International journal of cancer. 65(6)
Our study demonstrates that synthetic sialyl Lewis X (SLe x ) as a ligand for selectins and fibronectin-derived RGDS peptide analogue[Ar(DRGDS) 3 ] inhibits lung metastases produced by i.v. co-injection of B16-BL6 melanoma cells. To investigate the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f19c80046fdde37b9faa3d826f9a641
https://pubmed.ncbi.nlm.nih.gov/8631600
https://pubmed.ncbi.nlm.nih.gov/8631600
Autor:
Hiroyuki Komazawa, Ikuo Saiki, Naoyuki Nishikawa, Junya Yoneda, Yung Choon Yoo, Masayoshi Kojima, Mitsunori Ono, Isamu Itoh, Norio Nishi, Seiichi Tokurat, Ichiro Azuma
Publikováno v:
Clinicalexperimental metastasis. 11(6)
We have synthesized a new compound in which Arg-Gly-Asp-Ser (RGDS) was conjugated with 6-O-sulfated and 6-O-carboxymethyl-chitin (SCM-chitin), i.e. SCM-chitin-RGDS, and tested the inhibitory effect on lung and liver metastases of three different type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1229349706bbce93687d1ddab5bd3e04
https://pubmed.ncbi.nlm.nih.gov/8222396
https://pubmed.ncbi.nlm.nih.gov/8222396