Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Hiroyuki Koba"'
Autor:
Taiki Okumura, Takefumi Kimura, Yuki Ichikawa, Takanobu Iwadare, Shun-ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Takuro Uchida, Sai P. Pydi, Naoki Tanaka, Takeji Umemura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Thrombospondin 2 (TSP2) plays a vital role in collagen/fibrin formation, bone growth, vascular density regulation, hemostasis, and cell adhesion. Close associations of serum TSP2 with histological severity in non-alcoholic fatty liver diseas
Externí odkaz:
https://doaj.org/article/efbf9c3f37394982aa014cb4798abd89
Autor:
Sho Nishiguchi, Yuji Nishizaki, Miki Hamaguchi, Atshushi Goto, Masahiko Inamori, Kiyoshi Shikino, Tomohiro Shinozaki, Koshi Kataoka, Taro Shimizu, Yu Yamamoto, Sho Fukui, Hiroyuki Kobayashi, Yasuharu Tokuda
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background As healthcare professional trainees, resident physicians are expected to help with COVID-19 care in various ways. Many resident physicians worldwide have cared for COVID-19 patients despite the increased risk of burnout. However,
Externí odkaz:
https://doaj.org/article/6c969a7fa9e24473bbb8a4098a8be0ec
Autor:
Hiroshi Saijo, Yoshihiko Hirohashi, Osamu Honjo, Toyohiro Saikai, Naoki Shijubo, Hirotsugu Takabatake, Akihisa Fujita, Yasuhito Honda, Hiroyuki Koba, Hirofumi Chiba, Toshihiko Torigoe
Background Immunotherapy using immune checkpoint inhibitors (ICIs) has revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). Although several ICI options are available, the treatment regimen for NSCLC with large tumors (large N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2099abe1da36510ac4c016761c220a7
https://doi.org/10.21203/rs.3.rs-2069469/v1
https://doi.org/10.21203/rs.3.rs-2069469/v1
Autor:
Shotaro Hagiwara, Jun Komiyama, Masao Iwagami, Shota Hamada, Masato Komuro, Hiroyuki Kobayashi, Nanako Tamiya
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Older adults requiring care often have multiple morbidities that lead to polypharmacy, including the use of potentially inappropriate medications (PIMs), leading to increased medical costs and adverse drug effects. We conducted a
Externí odkaz:
https://doaj.org/article/1a1cd94d62e14ec088c16accb85c1b55
Autor:
Badr Sokrat, Anthony H. Nguyen, Alex R. B. Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W. Kahsai, Jihee Kim, Bing X. Ho, Symon Ma, John Little, Catherine Ehrhart, Ian Pyne, Emmery Hammond, Michel Bouvier
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Classically, G protein-coupled receptors (GPCRs) promote signaling at the plasma membrane through activation of heterotrimeric Gαβγ proteins, followed by the recruitment of GPCR kinases and βarrestin (βarr) to initiate receptor desensit
Externí odkaz:
https://doaj.org/article/5849f72408344b829ffc02844067159b
Autor:
Ken Nagino, Jaemyoung Sung, Akie Midorikawa-Inomata, Yasutsugu Akasaki, Takeya Adachi, Nobuyuki Ebihara, Ken Fukuda, Atsuki Fukushima, Kenta Fujio, Yuichi Okumura, Atsuko Eguchi, Keiichi Fujimoto, Hurramhon Shokirova, Alan Yee, Yuki Morooka, Tianxiang Huang, Kunihiko Hirosawa, Shintaro Nakao, Hiroyuki Kobayashi, Takenori Inomata
Publikováno v:
JMIR Formative Research, Vol 8, p e60731 (2024)
BackgroundAssessing changes in quality of life in patients with hay fever–related allergic conjunctivitis requires validated and clinically meaningful metrics. A minimal clinically important difference (MCID) that can be applied to assess Domain II
Externí odkaz:
https://doaj.org/article/44073e86e1d84d96bd1722e4d62cf605
Autor:
Kiyoshi Shikino, Yasuharu Tokuda, Yu Yamamoto, Taro Shimizu, Hiroyuki Kobayashi, Masanori Nojima, Sho Fukui, Daiki Yokokawa, Koshi Kataoka, Yuji Nishizaki, Kazuya Nagasaki
Publikováno v:
BMJ Open, Vol 14, Iss 10 (2024)
Objectives With physician maldistribution recognised as a global issue, Japan implemented the physician uneven distribution (PUD) index as a strategic measure. Currently, there is a lack of objective assessment of core clinical competencies in region
Externí odkaz:
https://doaj.org/article/317dd70315944493a6da3ccd667e2d11
Autor:
Xinrong Zou, Ken Nagino, Alan Yee, Akie Midorikawa-Inomata, Atsuko Eguchi, Shintaro Nakao, Hiroyuki Kobayashi, Takenori Inomata
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38674- (2024)
Background/objectives: Dry eye disease (DED) and myopia are common ocular disorders. This systematic review and meta-analysis investigated the association between DED and myopia. Methods: PubMed and EMBASE were searched for articles published between
Externí odkaz:
https://doaj.org/article/5a44a7e4837a43b584b34da627bcbaa1
Autor:
Takanobu Iwadare, Takefumi Kimura, Taiki Okumura, Shun-ichi Wakabayashi, Taro Nakajima, Shohei Kondo, Hiroyuki Kobayashi, Yuki Yamashita, Ayumi Sugiura, Naoyuki Fujimori, Tomoo Yamazaki, Hideo Kunimoto, Satoshi Shimamoto, Koji Igarashi, Satoru Joshita, Naoki Tanaka, Takeji Umemura
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract Background Circulating autotaxin (ATX) levels have been reported to correlate with liver inflammation activity and liver fibrosis severity in patients with non-alcoholic fatty liver disease (NAFLD). The objective of this study is to investig
Externí odkaz:
https://doaj.org/article/7bd204aa7e9f4f2cbac9920231994507
Autor:
Kiyoshi Shikino, Miwa Sekine, Yuji Nishizaki, Yu Yamamoto, Taro Shimizu, Sho Fukui, Kazuya Nagasaki, Daiki Yokokawa, Takashi Watari, Hiroyuki Kobayashi, Yasuharu Tokuda
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background In Japan, postgraduate clinical training encompasses a 2-year residency program, including at least 24 weeks of internal medicine (IM) rotations. However, the fragmented structure of these rotations can compromise the training’s
Externí odkaz:
https://doaj.org/article/9b50e8ab6ab5498aabadd4080f8f9770