Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Hiroyuki Kakei"'
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Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E
Autor: Masanori Okaniwa, Hiroyuki Kakei, Tomoyasu Ishikawa, Tomohiro Kawamoto, Takaharu Hirayama, Akihiro Yokota, Maki Miyamoto, Momoko Ohori, Kenichi Iwai, Hiroshi Banno, Akihiro Ohashi, Tadahiro Nambu
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:4296-4300
Centromere-associated protein-E (CENP-E) is a mitotic kinesin which plays roles in cell division, and is regarded as a promising therapeutic target for the next generation of anti-mitotic agents. We designed novel fused bicyclic CENP-E inhibitors sta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ff2e7ae2e49f60e3c025a32118bf5e
https://doi.org/10.1016/j.bmcl.2016.07.038
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Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents
Autor: Akihiro Ohashi, Kouji Mori, Hiroshi Banno, Takaharu Hirayama, Gotou Mika, Hiroyuki Kakei, Tomoyasu Ishikawa, Tomohiro Kawamoto, Momoko Ohori, Kenichi Iwai, Akihiro Yokota, Masanori Okaniwa
Publikováno v: Journal of medicinal chemistry. 58(20)
To develop centromere-associated protein-E (CENP-E) inhibitors for use as anticancer therapeutics, we designed novel imidazo[1,2-a]pyridines, utilizing previously discovered 5-bromo derivative 1a. By site-directed mutagenesis analysis, we confirmed t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe3d14cadb66e130d9852b9e4ca33a2
https://pubmed.ncbi.nlm.nih.gov/26372373
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Catalytic asymmetric epoxidation of α,β-unsaturated carboxylic acid imidazolides and amides by lanthanide–BINOL complexes
Autor: Takashi Ohshima, Masakatsu Shibasaki, Vijay Gnanadesikan, Tetsuhiro Nemoto, Hiroyuki Kakei, Shin Ya Tosaki
Publikováno v: Tetrahedron. 59:10485-10497
Highly enantioselective catalytic asymmetric epoxidation of α,β-unsaturated carboxylic acid imidazolides and simple amides was developed. In the presence of 5–10 mol% of lanthanide–BINOL complexes, the reaction proceeded smoothly with high subs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12e850d5f435ac22d5a100f957191c5b
https://doi.org/10.1016/j.tet.2003.06.010
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8
Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues
Autor: Dale L. Boger, Hiroyuki Kakei, Porino Va, Shigeki Seto, David A. Colby, Hayato Ishikawa, Thomas J. Rayl, Annie Tam, Inkyu Hwang
Full details of the development of a direct coupling of catharanthine with vindoline to provide vinblastine are described along with key mechanistic and labeling studies. Following an Fe(III)-promoted coupling reaction initiated by generation of a pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703cae645a57d9a034598cde1bfa90b2
https://europepmc.org/articles/PMC2727944/
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ChemInform Abstract: Catalytic Asymmetric Cyclopropanation of Enones with Dimethyloxosulfonium Methylide Promoted by a La—Li3—(Biphenyldiolate)3 + NaI Complex
Autor: Toshihiko Sone, Shigeki Matsunaga, Masakatsu Shibasaki, Hiroyuki Kakei, Yoshihiro Sohtome
Publikováno v: ChemInform. 39
Catalytic asymmetric cyclopropanation of enones with dimethyloxosulfonium methylide using a La−Li3−(biphenyldiolate)3 + NaI complex is described. The present method is complementary to the previously reported catalytic enantioselective methods in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d4bcd735bdc3a2a3eb679dedc5025c4
https://doi.org/10.1002/chin.200811032
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