Zobrazeno 1 - 10
of 412
pro vyhledávání: '"Hiroyuki Kagechika"'
Autor:
Xian-Yang Qin, Yutaka Furutani, Kento Yonezawa, Nobutaka Shimizu, Miyuki Kato-Murayama, Mikako Shirouzu, Yali Xu, Yumiko Yamano, Akimori Wada, Luc Gailhouste, Rajan Shrestha, Masataka Takahashi, Jeffrey W. Keillor, Ting Su, Wenkui Yu, Shinya Fujii, Hiroyuki Kagechika, Naoshi Dohmae, Yohei Shirakami, Masahito Shimizu, Takahiro Masaki, Tomokazu Matsuura, Harukazu Suzuki, Soichi Kojima
Publikováno v:
Cell Death and Disease, Vol 14, Iss 6, Pp 1-15 (2023)
Abstract Transglutaminase 2 (TG2) is a multifunctional protein that promotes or suppresses tumorigenesis, depending on intracellular location and conformational structure. Acyclic retinoid (ACR) is an orally administered vitamin A derivative that pre
Externí odkaz:
https://doaj.org/article/6988d4bd40ae412bb6f755ac1f920c89
Autor:
Saki Takayanagi, Kengo Watanabe, Takeshi Maruyama, Motoyuki Ogawa, Kazuhiro Morishita, Mayumi Soga, Tomohisa Hatta, Tohru Natsume, Tomoya Hirano, Hiroyuki Kagechika, Kazuki Hattori, Isao Naguro, Hidenori Ichijo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Recent studies have shown that adipose tissue is an immunological organ. While inflammation in energy-storing white adipose tissues has been the focus of intense research, the regulatory mechanisms of inflammation in heat-producing brown adi
Externí odkaz:
https://doaj.org/article/78dbffcfab81400ebbf62c50503ad2ba
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1113 (2023)
Less-calcaemic vitamin D receptor (VDR) agonists have the potential to promote osteoblast maturation in a bone regenerative setting. The emergence of lithocholic acid (LCA) as a bona fide VDR agonist holds promise as an adjunct for arthroplasty follo
Externí odkaz:
https://doaj.org/article/b0a9fad3db564ed986003a948bf0b2ea
Autor:
Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R. Lopez, Xiaochen Liu, Christine Diggle, Paul D. Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and tr
Externí odkaz:
https://doaj.org/article/afd2999f767e49b494c83b5f5e5c1a4b
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Background Intercellular communications are important for maintaining normal physiological processes. An important intercellular communication is mediated by the exchange of membrane-enclosed extracellular vesicles. Among various vesicles, e
Externí odkaz:
https://doaj.org/article/ee8f400dac9748b5b13f8b05d716f109
Autor:
Jennifer Nhieu, Liming Milbauer, Thomas Lerdall, Fatimah Najjar, Chin-Wen Wei, Ryosuke Ishida, Yue Ma, Hiroyuki Kagechika, Li-Na Wei
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4980 (2023)
All-trans-retinoic Acid (atRA) is the principal active metabolite of Vitamin A, essential for various biological processes. The activities of atRA are mediated by nuclear RA receptors (RARs) to alter gene expression (canonical activities) or by cellu
Externí odkaz:
https://doaj.org/article/1c5eafed84d7427a82c374d23e4bfd80
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 377-383 (2021)
A classical drug repurposing approach was applied to find new putative GPR40 allosteric binders. A two-step computational protocol was set up, based on an initial pharmacophoric-based virtual screening of the DrugBank database of known drugs, followe
Externí odkaz:
https://doaj.org/article/d8364e2f7b584f54becb9e34b3ffba54
Autor:
Matthew G. McDonald, Catherine K. Yeung, Aaron M. Teitelbaum, Amanda L. Johnson, Shinya Fujii, Hiroyuki Kagechika, Allan E. Rettie
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 892-899 (2019)
Vitamin K (VK), in both its phylloquinone and menaquinone forms, has been hypothesized to undergo ω- and β-oxidation on its hydrophobic side chain in order to generate the observed urinary metabolites, K acid I and K acid II, which are excreted pri
Externí odkaz:
https://doaj.org/article/f76ce9485fad4bcdba19644badf8ed00
Autor:
Manami Kodaka, Fengju Mao, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Xiaoyin Xu, Zeyu Yang, Kentaro Nakagawa, Junichi Maruyama, Kana Ishii, Chihiro Akazawa, Takuya Oyaizu, Naoki Yamamoto, Mari Ishigami-Yuasa, Nozomi Tsuemoto, Shigeru Ito, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231265 (2020)
Transcriptional co-activator with PDZ-binding motif (TAZ) plays versatile roles in the regulation of cell proliferation and differentiation. TAZ activity changes in response to the cellular environment such as mechanic and nutritional stimuli, osmola
Externí odkaz:
https://doaj.org/article/b70078fd67084d0c9c9d320b3df09460
Autor:
Ayana Yoshihara, Haru Kawasaki, Hiroyuki Masuno, Koki Takada, Nobutaka Numoto, Nobutoshi Ito, Naoya Hirata, Yasunari Kanda, Michiyasu Ishizawa, Makoto Makishima, Hiroyuki Kagechika, Aya Tanatani
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 130 (2022)
1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3, 1] is an active form of vitamin D3 and regulates various biological phenomena, including calcium and phosphate homeostasis, bone metabolism, and immune response via binding to and activation of vitamin D rec
Externí odkaz:
https://doaj.org/article/b359ac1d26e946909bc654659990f0b5