Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Hiroyuki Iwaki"'
Autor:
Hideyuki Matsunaga, Shigekazu Sasaki, Shingo Suzuki, Akio Matsushita, Hirotoshi Nakamura, Hiroko Misawa Nakamura, Naoko Hirahara, Go Kuroda, Hiroyuki Iwaki, Kenji Ohba, Hiroshi Morita, Yutaka Oki, Takafumi Suda
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142400 (2015)
The inhibition of thyrotropin (thyroid stimulating hormone; TSH) by thyroid hormone (T3) and its receptor (TR) is the central mechanism of the hypothalamus-pituitary-thyroid axis. Two transcription factors, GATA2 and Pit-1, determine thyrotroph diffe
Externí odkaz:
https://doaj.org/article/3e96c6a527fc44af97dd0fcb4abef5cf
Autor:
Hiroyuki Iwaki, Shigekazu Sasaki, Akio Matsushita, Kenji Ohba, Hideyuki Matsunaga, Hiroko Misawa, Yutaka Oki, Keiko Ishizuka, Hirotoshi Nakamura, Takafumi Suda
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e88610 (2014)
MYH7 (also referred to as cardiac myosin heavy chain β) gene expression is known to be repressed by thyroid hormone (T3). However, the molecular mechanism by which T3 inhibits the transcription of its target genes (negative regulation) remains to be
Externí odkaz:
https://doaj.org/article/ec7389fc650c40ddaf72f678f4f3071f
Autor:
Hiroko Misawa, Shigekazu Sasaki, Akio Matsushita, Kenji Ohba, Hiroyuki Iwaki, Hideyuki Matsunaga, Shingo Suzuki, Keiko Ishizuka, Yutaka Oki, Hirotoshi Nakamura
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28916 (2012)
Thyroid hormone receptor (TR) belongs to the nuclear hormone receptor (NHR) superfamily and regulates the transcription of its target genes in a thyroid hormone (T3)-dependent manner. While the detail of transcriptional activation by T3 (positive reg
Externí odkaz:
https://doaj.org/article/4da0f8e261c54b0687bb919b5c93146b
Autor:
Kenji Ohba, Shigekazu Sasaki, Akio Matsushita, Hiroyuki Iwaki, Hideyuki Matsunaga, Shingo Suzuki, Keiko Ishizuka, Hiroko Misawa, Yutaka Oki, Hirotoshi Nakamura
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18667 (2011)
Thyrotropin-releasing hormone (TRH) activates not only the secretion of thyrotropin (TSH) but also the transcription of TSHβ and α-glycoprotein (αGSU) subunit genes. TSHβ expression is maintained by two transcription factors, Pit1 and GATA2, and
Externí odkaz:
https://doaj.org/article/4500b53e2a7948d59a8fb717ed2a7471
Autor:
Yasuhisa Shinomura, Minoru Toyota, Kohzoh Imai, Koichi Hirata, Tadashi Hasegawa, Takashi Tokino, Hiroyuki Yamamoto, Eiichiro Yamamoto, Hiroyuki Takamaru, Yasuaki Miyazaki, Toshirou Nishida, Takayuki Nobuoka, Hiroyuki Iwaki, Masanori Nojima, Haruo Shimizu, Takeshi Niinuma, Hiromu Suzuki, Shinichi Igarashi
PDF file - 8K, Gene promoter hypermethylation in GIST samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0a84283ea3be6ab20007c99c14282d
https://doi.org/10.1158/1078-0432.22442240
https://doi.org/10.1158/1078-0432.22442240
Autor:
Yasuhisa Shinomura, Minoru Toyota, Kohzoh Imai, Koichi Hirata, Tadashi Hasegawa, Takashi Tokino, Hiroyuki Yamamoto, Eiichiro Yamamoto, Hiroyuki Takamaru, Yasuaki Miyazaki, Toshirou Nishida, Takayuki Nobuoka, Hiroyuki Iwaki, Masanori Nojima, Haruo Shimizu, Takeshi Niinuma, Hiromu Suzuki, Shinichi Igarashi
PDF file - 5K, Logistic regression analysis for the association between metastasis and LINE-1 methylation in high-risk category GIST patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa2e4c915a9d5e53d60a84d9aa77658
https://doi.org/10.1158/1078-0432.22442243.v1
https://doi.org/10.1158/1078-0432.22442243.v1
Autor:
Yasuhisa Shinomura, Minoru Toyota, Kohzoh Imai, Koichi Hirata, Tadashi Hasegawa, Takashi Tokino, Hiroyuki Yamamoto, Eiichiro Yamamoto, Hiroyuki Takamaru, Yasuaki Miyazaki, Toshirou Nishida, Takayuki Nobuoka, Hiroyuki Iwaki, Masanori Nojima, Haruo Shimizu, Takeshi Niinuma, Hiromu Suzuki, Shinichi Igarashi
PDF file - 364K, Reproducibility of bisulfite pyrosequencing analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a1484375e58f4e6cda840578863d4d
https://doi.org/10.1158/1078-0432.22442249
https://doi.org/10.1158/1078-0432.22442249
Autor:
Yasuhisa Shinomura, Minoru Toyota, Kohzoh Imai, Koichi Hirata, Tadashi Hasegawa, Takashi Tokino, Hiroyuki Yamamoto, Eiichiro Yamamoto, Hiroyuki Takamaru, Yasuaki Miyazaki, Toshirou Nishida, Takayuki Nobuoka, Hiroyuki Iwaki, Masanori Nojima, Haruo Shimizu, Takeshi Niinuma, Hiromu Suzuki, Shinichi Igarashi
Purpose: Gastrointestinal stromal tumors (GIST) are the most important mesenchymal tumors of the gastrointestinal tract. The vast majority of GISTs exhibit activating mutations of KIT or PDGFRA, but epigenetic alteration of GISTs is largely unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a78be4c31a149bf3bf573ceb686db9
https://doi.org/10.1158/1078-0432.c.6519032
https://doi.org/10.1158/1078-0432.c.6519032
Autor:
Yasuhisa Shinomura, Minoru Toyota, Kohzoh Imai, Koichi Hirata, Tadashi Hasegawa, Takashi Tokino, Hiroyuki Yamamoto, Eiichiro Yamamoto, Hiroyuki Takamaru, Yasuaki Miyazaki, Toshirou Nishida, Takayuki Nobuoka, Hiroyuki Iwaki, Masanori Nojima, Haruo Shimizu, Takeshi Niinuma, Hiromu Suzuki, Shinichi Igarashi
PDF file - 507K, Chromosomal aberrations and their frequencies determined through array CGH analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d237c5639e7942326d488c08d4a49d
https://doi.org/10.1158/1078-0432.22442246
https://doi.org/10.1158/1078-0432.22442246
Autor:
Tadashi Hasegawa, Mayuko Akimoto, Yoshihiko Hirohashi, Noriaki Kikuchi, Tomoki Kikuchi, Tatsuru Ikeda, Kiyoshi Kasai, Terufumi Kubo, Yasuhiro Kikuchi, Tomoyo Shinkawa, Kenji Murata, Hiroyuki Iwaki, Yoshiko Keira, Toshihiko Torigoe, Tomohide Tsukahara, Masahiko Obata, Keiko Segawa, Rena Morita, Takayuki Kanaseki
Publikováno v:
Cancer Science
Immune checkpoint inhibitors (ICIs) have provided an additional treatment option for various types of human cancers. However, ICIs often induce various immune‐related adverse events (irAEs). Enterocolitis is a major irAE with poorly understood hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3470f766fee64a6da3b6c9bb582710cb
https://doi.org/10.1111/cas.14773
https://doi.org/10.1111/cas.14773