Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hiroyuki Hozumi"'
Autor:
Eriya Kenjo, Hiroyuki Hozumi, Yukimasa Makita, Kumiko A. Iwabuchi, Naoko Fujimoto, Satoru Matsumoto, Maya Kimura, Yuichiro Amano, Masataka Ifuku, Youichi Naoe, Naoto Inukai, Akitsu Hotta
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
In vivo delivery of CRISPR-Cas9 holds promise for treating muscular dystrophy, however, AAV delivery is known to be immunogenic. Here, the authors show that LNP delivery of CRISPR-Cas9 enables repeated injections into skeletal muscle and leads to res
Externí odkaz:
https://doaj.org/article/82ba1424688643b8923145dd7be8e610
Autor:
Peter Gee, Mandy S. Y. Lung, Yuya Okuzaki, Noriko Sasakawa, Takahiro Iguchi, Yukimasa Makita, Hiroyuki Hozumi, Yasutomo Miura, Lucy F. Yang, Mio Iwasaki, Xiou H. Wang, Matthew A. Waller, Nanako Shirai, Yasuko O. Abe, Yoko Fujita, Kei Watanabe, Akihiro Kagita, Kumiko A. Iwabuchi, Masahiko Yasuda, Huaigeng Xu, Takeshi Noda, Jun Komano, Hidetoshi Sakurai, Naoto Inukai, Akitsu Hotta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Expression of Cas9 and gRNA from viral vectors in vivo may cause off-target activity. Here the authors present NanoMEDIC, which uses nanovesicles to transiently deliver editing machinery to hard-to-transfect cells.
Externí odkaz:
https://doaj.org/article/4d0fe2ef9a604f0fb6865d1e08b1ed50
Autor:
Kumiko Iwabuchi, Akihiro Kagita, Lucy F. Yang, Nanako Shirai, Takahiro Iguchi, Yoko Fujita, Jun Komano, Takeshi Noda, Akitsu Hotta, Noriko Sasakawa, Yukimasa Makita, Matthew A. Waller, Naoto Inukai, Peter Gee, Mio Iwasaki, Mandy S. Y. Lung, Hidetoshi Sakurai, Yasuko O. Abe, Xiou H. Wang, Yasutomo Miura, Kei Watanabe, Masahiko Yasuda, Hiroyuki Hozumi, Huaigeng Xu, Yuya Okuzaki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Prolonged expression of the CRISPR-Cas9 nuclease and gRNA from viral vectors may cause off-target mutagenesis and immunogenicity. Thus, a transient delivery system is needed for therapeutic genome editing applications. Here, we develop an extracellul
Publikováno v:
Clinical calcium. 27(3)
Recent advances in genome editing technologies have opened the possibility for treating genetic diseases, such as Duchenne muscular dystrophy(DMD), by correcting the causing gene mutations in dystrophin gene. In fact, there are several reports that d
Autor:
Hiroyuki Hozumi, Yoshitaka Yasuhara, Hiromitsu Fuse, Ryuichi Tozawa, Kimihiko Iwachidow, Masahiro Oka, Yusuke Moritoh
Publikováno v:
Scientific Reports
Inositol hexakisphosphate kinase 3 (IP6K3) generates inositol pyrophosphates, which regulate diverse cellular functions. However, little is known about its own physiological role. Here, we show the roles of IP6K3 in metabolic regulation. We detected
Publikováno v:
Annual Report of The Kansai Plant Protection Society. 54:13-16
Publikováno v:
Journal of Veterinary Medical Science. 68:959-965
We have previously produced human growth hormone (hGH) transgenic (TG) rats that show low circulating levels of both hGH and endogenous rat GH. Although body length of the TG rats is normal, they develop hyperphagia and severe obesity. The present st
Publikováno v:
Experimental Gerontology. 39:1179-1188
Growth hormone (GH) is essential in the development and growth of the skeleton and for the maintenance of bone mass and density, and its secretion is known to decline with aging. We have previously produced transgenic rats with low circulating GH tha
Autor:
Juri Hori, Katsuhiro Kitagawa, Ryoichi Sato, Fumiyo Yamashita, Kenta Yamada, Masaya Shida, Hiroyuki Hozumi
Publikováno v:
The Proceedings of the Annual Convention of the Japanese Psychological Association. 74:2EV027-2EV027
Autor:
Juri Hori, Katsuhiro Kitagawa, Hiroyuki Hozumi, Ryoichi Sato, Kenta Yamada, Fumiyo Yamashita, Masaya Shida
Publikováno v:
The Proceedings of the Annual Convention of the Japanese Psychological Association. 74:2EV028-2EV028