Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Hiroyuki Hanzawa"'
1
Akademický článek
The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
Autor: Ryohei Katayama, Bo Gong, Noriko Togashi, Masaya Miyamoto, Masaki Kiga, Shiho Iwasaki, Yasuki Kamai, Yuichi Tominaga, Yasuyuki Takeda, Yoshiko Kagoshima, Yuki Shimizu, Yosuke Seto, Tomoko Oh-hara, Sumie Koike, Naoki Nakao, Hiroyuki Hanzawa, Kengo Watanabe, Satoshi Yoda, Noriko Yanagitani, Aaron N. Hata, Alice T. Shaw, Makoto Nishio, Naoya Fujita, Takeshi Isoyama
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The treatment of ROS1-rearranged non-small cell lung cancer with the TKI crizotinib is limited due to the emergence of resistance. Here, the authors develop a new ROS1/NTRK inhibitor, DS-6051b, which overcomes crizotinib resistance in preclinical mod
Externí odkaz: https://doaj.org/article/1fb146a2c258459e81f631757ffb5a98
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2
Akademický článek
Reassessment of the unique mode of binding between angiotensin II type 1 receptor and their blockers.
Autor: Shin-Ichiro Miura, Naoki Nakao, Hiroyuki Hanzawa, Yoshino Matsuo, Keijiro Saku, Sadashiva S Karnik
Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79914 (2013)
While the molecular structures of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are very similar, they are also slightly different. Although each ARB has been shown to exhibit a unique mode of binding to AT1 receptor, different positi
Externí odkaz: https://doaj.org/article/9f56b096fbab474a910b142062c1772b
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4
Akademický článek
Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor.
Autor: Shin-ichiro Miura, Yoshihiro Kiya, Hiroyuki Hanzawa, Naoki Nakao, Masahiro Fujino, Satoshi Imaizumi, Yoshino Matsuo, Hiroaki Yanagisawa, Hiroyuki Koike, Issei Komuro, Sadashiva S Karnik, Keijiro Saku
Publikováno v: PLoS ONE, Vol 7, Iss 6, p e37974 (2012)
Small differences in the chemical structures of ligands can be responsible for agonism, neutral antagonism or inverse agonism toward a G-protein-coupled receptor (GPCR). Although each ligand may stabilize the receptor conformation in a different way,
Externí odkaz: https://doaj.org/article/e67898d977f84a6f9749664b86ef1e48
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8
Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains
Autor: Takaaki Akasaka, Ryoichi Hamasuna, Hisami Aono, Masahiro Matsumoto, Jørgen Skov Jensen, Ikko Tomisaki, Hiroyuki Hanzawa, Ayako Moritomo, Naohiro Fujimoto
Publikováno v: Journal of Infection and Chemotherapy. 28:377-383
Introduction The mechanisms of fluoroquinolone-resistance of Mycoplasma genitalium were analysed by a new method. Methods M. genitalium strains from urinary sediments of patients with urethritis were isolated and examined antimicrobial susceptibiliti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81690dc0158e1509e0c0c219f423eb02
https://doi.org/10.1016/j.jiac.2021.11.011
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10
Conformational Plasticity of Cyclic Ras‐Inhibitor Peptides Defines Cell Permeabilization Activity
Autor: Miwa Fujisaki, Yuji Tokunaga, Ichio Shimada, Hajime Kamoshida, Hiroyuki Hanzawa, Takeshi Takizawa, Koh Takeuchi, Imai Misaki
Publikováno v: Angewandte Chemie International Edition. 60:6567-6572
Cyclorasins 9A5 and 9A54 are 11-mer cyclic peptides that inhibit the Ras-Raf protein interaction. The peptides share a cell-penetrating peptide (CPP)-like motif; however, only cyclorasin 9A5 can permeabilize cells to exhibit strong cell-based activit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a734ff9aed4852c9eb27187ac5522a
https://doi.org/10.1002/anie.202016647
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Plný text Recenzováno Digitální knihovna AV ČR
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