Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Hiroyuki Chaya"'
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Akademický článek
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Autor: Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nanoparticle delivery of siRNA has problems with penetration and off target accumulation. Here, the authors report on the development of Y-shaped block catiomers which dynamically wrap around siRNA; demonstrate increased circulation times and deliver
Externí odkaz: https://doaj.org/article/e56544229bd24572b3344d7cb418ce63
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3
Dynamic Stabilization of Unit Polyion Complexes Incorporating Small Interfering RNA by Fine-Tuning of Cationic Block Length in Two-Branched Poly(ethylene glycol)
Autor: Hiroyuki Chaya, Mitsuru Naito, Masaru Cho, Kazuko Toh, Kotaro Hayashi, Shigeto Fukushima, Yuichi Yamasaki, Kazunori Kataoka, Kanjiro Miyata
Publikováno v: Biomacromolecules. 23(1)
To stabilize small interfering RNA (siRNA) in the bloodstream for systemic RNAi therapeutics, we previously fabricated ultrasmall siRNA nanocarriers that were sub-20 nm in hydrodynamic diameter, named as unit polyion complexes (uPICs), using two-bran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89ecccf2e140f1eb26d1b5aed73830b
https://pubmed.ncbi.nlm.nih.gov/34935361
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4
Noncovalent Stabilization of Vesicular Polyion Complexes with Chemically Modified/Single-Stranded Oligonucleotides and PEG
Autor: Beob Soo, Kim, Mitsuru, Naito, Hiroyuki, Chaya, Mao, Hori, Kotaro, Hayashi, Hyun Su, Min, Yu, Yi, Hyun Jin, Kim, Tetsuya, Nagata, Yasutaka, Anraku, Akihiro, Kishimura, Kazunori, Kataoka, Kanjiro, Miyata
Publikováno v: Biomacromolecules. 21(10)
For the simultaneous delivery of antisense oligonucleotides and their effector enzymes into cells, nanosized vesicular polyion complexes (PICs) were fabricated from oppositely charged polyion pairs of oligonucleotides and poly(ethylene glycol) (PEG)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9f8f189680005f75b204ffcfe2e1718
https://pubmed.ncbi.nlm.nih.gov/32924444
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5
Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(l-lysine)
Autor: Kanjiro Miyata, Kotaro Hayashi, Takanori Yokota, Shigeto Fukushima, Hiroyuki Chaya, Kazunori Kataoka, Mitsuru Naito, Beob Soo Kim, Kazuko Toh, Tetsuya Nagata
Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 330
Downsizing nanocarriers is a promising strategy for systemically targeting fibrotic cancers, such as pancreatic cancer, owing to enhanced tissue permeability. We recently developed a small oligonucleotide nanocarrier called a unit polyion complex (uP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9933a81e9bbb34f8e28e04a66aa92e08
https://pubmed.ncbi.nlm.nih.gov/33417983
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Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers
Autor: Kensuke Osada, Hiroyasu Takemoto, Kazunori Kataoka, Nobuhiro Nishiyama, Hiroyuki Chaya, Kanjiro Miyata, Kotaro Hayashi, Sumiyo Watanabe, Shigeto Fukushima
Publikováno v: Macromolecular Rapid Communications. 37(No. 6):486-493
Polyion complexes (b-PICs) are prepared by mixing single- or double-stranded oligo RNA (aniomer) with poly(ethylene glycol)-b-poly(L-lysine) (PEG-PLL) (block catiomer) to clarify the effect of aniomer chain rigidity on association behaviors at varyin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ea26d77e9d7372e19ee92b206290d2
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100720773
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Pharmacokinetic and Pharmacodynamic Profiles of Glyco-Modified Atrial Natriuretic Peptide Derivatives Synthesized Using Chemo-enzymatic Synthesis Approaches
Autor: Hiroyuki Chaya, Takahiro Nagayama, Makoto Yoshida, Yukiko Sekiguchi, Jun Hasegawa, Nakamura Kensuke, Takeshi Shiiki, Masako Soma, Shohei Oishi, Takahiro Yamaguchi, Takeshi Honda, Yutaka Mori, Ryuki Miyauchi, Iwamoto Mitsuhiro
Publikováno v: Bioconjugate chemistry. 29(8)
Atrial natriuretic peptide (ANP) exerts beneficial pharmacological effects in the treatment of various cardiovascular disorders, such as acute congestive heart failure (ADHF). However, the clinical use of ANP is limited to the continuous intravenous
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ded42d5421c78b4903f17c00f6d28af
https://pubmed.ncbi.nlm.nih.gov/30107743
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Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold Nanoparticles
Autor: Kazuko Toh, Frederico Pittella, Hiroyasu Takemoto, Yoshinori Maeda, R. James Christie, Kazunori Kataoka, Kanjiro Miyata, Hiroyuki Chaya, Kotaro Hayashi, Nobuhiro Nishiyama, Yu Yi, Peng Mi, Yu Matsumoto, Hyun Jin Kim, Meng Zheng
Publikováno v: Acs Nano. 8(No. 9):8979-8991
For systemic delivery of siRNA to solid tumors, a size-regulated and reversibly stabilized nanoarchitecture was constructed by using a 20 kDa siRNA-loaded unimer polyion complex (uPIC) and 20 nm gold nanoparticle (AuNP). The uPIC was selectively prep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca8f5838a12fc488e97bbb25952c6d2
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100720784
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9
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Autor: Kazuko Toh, Hiroaki Kinoh, Hiroyasu Takemoto, Mitsunobu R. Kano, Hiroshi Fukuhara, Sumiyo Watanabe, Keisuke Katsushima, Nobuhiro Nishiyama, Kotaro Hayashi, Yutaka Kondo, Hiroyuki Chaya, Satoshi Uchida, Satomi Ogura, Kanjiro Miyata, Takahiro Nomoto, Hyun Jin Kim, Horacio Cabral, Masaomi Nangaku, Kazunori Kataoka, Shigeto Fukushima, Shunya Uchida, Kensuke Osada, Xueying Liu, Yu Matsumoto, Hiroyoshi Y. Tanaka
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Stabilisation of fragile oligonucleotides, typically small interfering RNA (siRNA), is one of the most critical issues for oligonucleotide therapeutics. Many previous studies encapsulated oligonucleotides into ~100-nm nanoparticles. However, such nan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e681b4e8b335d42bea454a42055b10a
https://repo.qst.go.jp/records/77026
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