Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Hiroyuki Akita"'
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 123:160-166
Lipase-catalyzed kinetic resolution of γ-cyclogeraniol by Candida antarctica lipase B yielded 23% of enantiomerically pure (S)-γ-cyclogeraniol. (+)-trixagol and (+)-luffarin-P were synthesized from the obtained (S)-γ-cyclogeraniol, and the absolut
Autor:
Yorishige Imamura, Hideaki Shimada, Kazunori Matayoshi, Hiroyuki Takayama, Ken Babazono, Toshiyuki Higuchi, Takahiro Tanigawa, Masashi Eto, Kazufumi Katakura, Hiroyuki Akita, Tsuyoshi Murahashi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 29:397-400
Context and objective: The present study is to elucidate the comparative inhibition of tetrameric carbonyl reductase (TCBR) activity by alkyl 4-pyridyl ketones, and to characterize its substrate-binding domain.Materials and methods: The inhibitory ef
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:1076-1082
The addition of 4 eq of chloral to osmundalactone (4S,5R)-4 gave quantitative formation of the hemiacetal derivative (4S,5R)-8, which was treated with methane sulfonic acid to afford the intramolecular Micheal addition product (+)-(3S,4S,5R)-9 posses
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 69:21-26
For the purpose of preparation of optically active aminoalcohol congeners possessing both hydroxyl- and dialkylamino-substituted vicinal chiral carbons, lipase-assisted acylation of methyl (2E,4R*,5S*)-4-(N-benzyl-N-methyl)amino-5-hydroxyhex-2-enoate
Autor:
Hiroyuki Akita
Publikováno v:
YAKUGAKU ZASSHI. 131:269-284
This review summarizes the chemoenzymatic synthesis of the biologically active natural products based on a combination of chemical diastereoselectivity and enzymatic enantioselectivity using biocatalyst. Asymmetric reduction of 2-methyl-3-keto ester
Publikováno v:
Tetrahedron: Asymmetry. 21:494-499
The total synthesis of methyl β- d -vicenisaminide 1 has been achieved. In this approach, the synthesis of enantiomerically pure methyl (4 R ,5 S )- and (4 S ,5 R )-4-azido-5-hydroxy-2( E )-hexenoates 2 was established by enzymatic resolution of (±
Publikováno v:
Chemical and Pharmaceutical Bulletin. 58:1411-1418
The reaction of 2,3-anti-2-tert-butyldimethylsiloxy-3-substituted butanal derivative [anti-B, (±)-10 and (±)-16] derived from trans-(2,3)-epoxy butanoate (1) with carbon nucleophiles [α-furyl anion, acetate anion, and indium (In)-assisted allyl an
Autor:
Norio Kawahara, Toshie Miura, Irie Miyoshi, Hiroyuki Akita, Megumi Mizukami, Masanori Imai, Shinji Nagumo
Publikováno v:
Tetrahedron. 65:9884-9896
The 7-endo Friedel–Crafts cyclization of arylpropyl vinyloxiranes was found to proceed regio- and stereoselectively to afford polyfunctional seven-membered carbocycles in excellent yields.
Publikováno v:
Tetrahedron: Asymmetry. 20:1975-1983
The convergent syntheses of (+)-piericidin A 1 1 and (−)-piericidin B 1 2 have been achieved based on classical Julia-Lythgoe olefination between 4-hydroxy-5,6-dimethoxy-3-methyl-2-[5-oxo-3-methyl-pent-(2 E )-enyl]-pyridine 3 corresponding to the l
Publikováno v:
Tetrahedron Letters. 50:4941-4944
All stereoisomers of 2-allyl-3-hydroxy-2-methylcyclopentanones 2 – 5 were prepared in high conversion and in an optically pure form by microbial reduction and oxidation. The reduction of symmetric diketone 1 by Geotrichum candidum NBRC 4597 under a