Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Hiroyuki Sakagami"'
Autor:
Akiko Ito, Masahiro Fukaya, Takeyuki Sugawara, Yoshinobu Hara, Hirotsugu Okamoto, Junji Yamauchi, Hiroyuki Sakagami
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105466- (2021)
Group I metabotropic glutamate receptors (mGluRs), mGluR1 and mGluR5, in the spinal cord are implicated in nociceptive transmission and plasticity through G protein-mediated second messenger cascades leading to the activation of various protein kinas
Externí odkaz:
https://doaj.org/article/015336794e6449899acd82ac1423a0c6
Autor:
Manabu Murakami, Agnieszka M Murakami, Yasushi Matsuzaki, Daisuke Sawamura, Takayoshi Ohba, Ichirou Miyoshi, Shirou Itagaki, Hiroyuki Sakagami
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249932 (2021)
In the present study, we examined the importance of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) in the regulation of cardiac function using genetically modified CaMKIV-null mice. RT-PCR analysis revealed decreased expression of voltage-depen
Externí odkaz:
https://doaj.org/article/7ec9f4aafb6849c498e9bc2d1bef0905
Autor:
Ryo Nishinarita, Shinichi Niwano, Hiroe Niwano, Hironori Nakamura, Daiki Saito, Tetsuro Sato, Gen Matsuura, Yuki Arakawa, Shuhei Kobayashi, Yuki Shirakawa, Ai Horiguchi, Naruya Ishizue, Tazuru Igarashi, Tomoharu Yoshizawa, Jun Oikawa, Yoshinobu Hara, Takafumi Katsumura, Jun Kishihara, Akira Satoh, Hidehira Fukaya, Hiroyuki Sakagami, Junya Ako
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 2 (2021)
Background Recent clinical trials have demonstrated the possible pleiotropic effects of SGLT2 (sodium–glucose cotransporter 2) inhibitors in clinical cardiovascular diseases. Atrial electrical and structural remodeling is important as an atrial fib
Externí odkaz:
https://doaj.org/article/ad5e849bb10448688603fcd627c34aea
Autor:
Marisa Kaneda, Hiroyuki Sakagami, Yamato Hida, Toshihisa Ohtsuka, Natsumi Satou, Yuta Ishibashi, Mamoru Fukuchi, Anna Krysiak, Mitsuru Ishikawa, Daisuke Ihara, Katarzyna Kalita, Akiko Tabuchi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract The megakaryoblastic leukaemia (MKL) family are serum response factor (SRF) coactivators, which are highly expressed in the brain. Accordingly, MKL plays important roles in dendritic morphology, neuronal migration, and brain development. Fur
Externí odkaz:
https://doaj.org/article/88d1491198894e9e8bae2c3933ed5fc8
Publikováno v:
IBRO Reports, Vol 3, Iss C, Pp 9-16 (2017)
Glycine is an inhibitory neurotransmitter in the brainstem and spinal cord. Glycine transporter 2 (GLYT2) is responsible for the uptake of extracellular glycine. GLYT2 is specifically expressed in glycinergic neurons and thus has been used as a marke
Externí odkaz:
https://doaj.org/article/c55c01df08ac465eb73563e61984ecf4
Autor:
Ruri Tsuneishi, Naoto Matsumoto, Misa Itaoka, Yuri Urai, Minami Kaneko, Natsumi Watanabe, Shou Takashima, Yoichi Seki, Takako Morimoto, Hiroyuki Sakagami, Yuki Miyamoto, Junji Yamauchi
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 234-239 (2017)
Cytohesin-1 is the guanine-nucleotide exchange factor of Arf6, a small GTPase of Arf family, and participates in cellular morphological changes. Knockout mice of cytohesin-1 exhibit decreased myelination of neuronal axons in the peripheral nervous sy
Externí odkaz:
https://doaj.org/article/88ec67a921f046408e20bccd5e9c90ee
Autor:
Kosuke Okuda, Shizuka Kobayashi, Masahiro Fukaya, Aya Watanabe, Takuto Murakami, Mai Hagiwara, Tempei Sato, Hiroe Ueno, Narumi Ogonuki, Sayaka Komano-Inoue, Hiroyuki Manabe, Masahiro Yamaguchi, Atsuo Ogura, Hiroshi Asahara, Hiroyuki Sakagami, Masashi Mizuguchi, Toshiya Manabe, Teruyuki Tanaka
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 158-170 (2017)
Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders accompanied by intractable epilepsies, i.e. West syndrome or atypical Rett syndrome. Here we report generation of the Cdkl5 knockout mouse and show
Externí odkaz:
https://doaj.org/article/65ef178d53264c5d82504f6b9d16c3ba
Autor:
Naoko Imaizumi, Yu Takeuchi, Haruka Hirano, Tomohiro Torii, Yoichi Seki, Takako Morimoto, Yuki Miyamoto, Hiroyuki Sakagami, Junji Yamauchi
Publikováno v:
Data in Brief, Vol 25, Iss , Pp - (2019)
Charcot-Marie-Tooth (CMT) diseases are genetic neuropathies in the peripheral nervous system (PNS). Type 1 CMT diseases are neuropathies in Schwann cells, PNS myelinating glial cells, whereas type 2 CMT diseases are axonal neuropathies. In addition,
Externí odkaz:
https://doaj.org/article/b52fd32e162847dcbced1095789f8c0b
Autor:
Shintaro Saegusa, Masahiro Fukaya, Wataru Kakegawa, Manabu Tanaka, Osamu Katsumata, Takeyuki Sugawara, Yoshinobu Hara, Makoto Itakura, Tadashi Okubo, Toshiya Sato, Michisuke Yuzaki, Hiroyuki Sakagami
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216960 (2019)
ADP ribosylation factor 6 (Arf6) is a small GTPase that regulates various neuronal events including formation of the axon, dendrites and dendritic spines, and synaptic plasticity through actin cytoskeleton remodeling and endosomal trafficking. EFA6C,
Externí odkaz:
https://doaj.org/article/4c0abf6b9e874d7b91bbbfce6a46dbe6
Autor:
Riku Kaneshige, Satomi Ohtsuka, Yuhei Harada, Issei Kawamata, Masaki Magari, Naoki Kanayama, Naoya Hatano, Hiroyuki Sakagami, Hiroshi Tokumitsu
Publikováno v:
The FEBS Journal. 289:5971-5984
Calcium/calmodulin-dependent protein kinase kinases (CaMKKs) activate CaMKI, CaMKIV, protein kinase B/Akt, and AMP-activated protein kinase (AMPK) by phosphorylating Thr residues in activation loops to mediate various Ca2+-signaling pathways. Mammali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18500dd6671cbb4f2f34536e2bacb3b5
https://doi.org/10.1111/febs.16467
https://doi.org/10.1111/febs.16467