Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hiroyuki, Sugumi"'
Autor:
Kentaro Yoshimatsu, Katsuji Nakamura, Takeshi Nagasu, Hiroyuki Sugumi, Jun Niijima, Toshimi Okada, Toshimitsu Uenaka, Nozomu Koyanagi, Kappei Tsukahara, Atsumi Yamaguchi, Hiroshi Yoshino, Kyosuke Kitoh, Junichi Kamata, Yoshihiko Kotake
Publikováno v:
Chemical and Pharmaceutical Bulletin. 52:1071-1081
As part of a series of studies to discover new topoisomerase II inhibitors, novel pyrimidoacridones, pyrimidophenoxadines, and pyrimidocarbazoles were synthesized, and in vitro and in vivo antitumor activities and DNA-protein and/or DNA-topoisomerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dc5f0c0baabab56e3b6f243222fc67
https://doi.org/10.1248/cpb.52.1071
https://doi.org/10.1248/cpb.52.1071
Autor:
Yuoichi Iimura, Hiroyuki Sugumi, Kunizou Higurashi, Norio Karibe, Hachiro Sugimoto, Yutaka Tsuchiya
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ea0e60416a1dd354545eff5d68eac91
https://doi.org/10.1002/chin.199114178
https://doi.org/10.1002/chin.199114178
Autor:
Kiyomi Yamatsu, Hiroyuki Sugumi, Yutaka Tsuchiya, Atsushi Sasaki, Kunizo Higurashi, Yoshiharu Yamanishi, Norio Karibe, Hachiro Sugimoto, Shin Araki, Yoichi Iimura
Publikováno v:
ChemInform. 25
Following the discovery of a new series of 1-benzyl-4-[2-(N-benzoyl-N-methylamino)ethyl]piperidine (2) derivatives with a potent anti-acetylcholinesterase (anti-AChE) activity, we extended the structure-activity relationships (SAR) to rigid analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48418bc043e4f7420518d92a56f1677e
https://doi.org/10.1002/chin.199410176
https://doi.org/10.1002/chin.199410176
Autor:
Atsushi Sasaki, Youichi Iimura, Kunizo Higurashi, Yutaka Tsuchiya, Hiroyuki Sugumi, Y Kawakami, Norio Karibe, T Nakamura, Hachiro Sugimoto, Shin Araki
Publikováno v:
Journal of Medicinal Chemistry. 33:1880-1887
A series of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives was synthesized and evaluated for anti-acetylcholinesterase (anti-AChE) activity. Substituting the benzamide with a bulky moiety in the para position led to a substantial increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056c79d7fe20f9525541ab376e8c2c07
https://doi.org/10.1021/jm00169a008
https://doi.org/10.1021/jm00169a008
Autor:
Toshimitsu Uenaka, Hiroshi Yoshino, Tomoyoshi Taniguchi, Takeshi Nagasu, Katsuji Nakamura, Yoshihiko Kotake, Nozomu Koyanagi, Hiroyuki Sugumi, Jun Niijima, Toshimi Okada, Kentaro Yoshimatsu, Atsumi Yamaguchi, Kyosuke Kitoh, Junichi Kamata
Publikováno v:
Cancer science. 94(1)
We have discovered a novel topoisomerase II (topo II) poison, ER-37328 (12,13-dihydro-5-[2-(dimethylamino)ethyl]-4H-benzo[c]pyrimido[5,6,1-jk]carbazole-4,6,10(5H,11H)-trione hydrochloride), which shows potent tumor regression activity against Colon 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93373ed80d2a520906c27a06783053c3
https://pubmed.ncbi.nlm.nih.gov/12708485
https://pubmed.ncbi.nlm.nih.gov/12708485
Autor:
Katsuji, Nakamura, Hiroyuki, Sugumi, Atsumi, Yamaguchi, Toshimitsu, Uenaka, Yoshihiko, Kotake, Toshimi, Okada, Junichi, Kamata, Jun, Niijima, Takeshi, Nagasu, Nozomu, Koyanagi, Hiroshi, Yoshino, Kyosuke, Kitoh, Kentaro, Yoshimatsu
Publikováno v:
Molecular cancer therapeutics. 1(3)
DNA topoisomerase II has been shown to be an important therapeutic target in cancer chemotherapy. Here, we describe studies on the antitumor activity of a novel topoisomerase II inhibitor, ER-37328 [12,13-dihydro-5-[2-(dimethylamino)ethyl]-4H-benzo[c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c50add1f41eaf7458e971ba720077bf
https://pubmed.ncbi.nlm.nih.gov/12467211
https://pubmed.ncbi.nlm.nih.gov/12467211
Autor:
Kiyomi Yamatsu, Hiroyuki Sugumi, Yoshiharu Yamanishi, Norio Karibe, Atsushi Sasaki, Yutaka Tsuchiya, Kunizo Higurashi, Yoichi Iimura, Hachiro Sugimoto, Shin Araki
Publikováno v:
Journal of medicinal chemistry. 35(24)
Following the discovery of a new series of 1-benzyl-4-[2-(N-benzoyl-N-methylamino)ethyl]piperidine (2) derivatives with a potent anti-acetylcholinesterase (anti-AChE) activity, we extended the structure-activity relationships (SAR) to rigid analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcce7a8da170e6dc508a19aad5bd14e9
https://pubmed.ncbi.nlm.nih.gov/1469686
https://pubmed.ncbi.nlm.nih.gov/1469686
Autor:
Hiroshi Yoshino, Norihiro Ueda, Jun Niijima, Hiroyuki Sugumi, Yoshihiko Kotake, Nozomu Koyanagi, Kentaro Yoshimatsu, Makoto Asada, Tatsuo Watanabe, Takeshi Nagasu, Kappei Tsukahara, Atsumi Iijima, Kyosuke Kitoh
Publikováno v:
Journal of medicinal chemistry. 35(13)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b26ba5147b01a45682f3bedd259a318
https://pubmed.ncbi.nlm.nih.gov/1619621
https://pubmed.ncbi.nlm.nih.gov/1619621
Publikováno v:
Chemistry Letters. 16:1691-1694
In the presence of trityl tetrafluoroborate, 2-(2-ethylthioalkylidene)-1,3-dithiolanes smoothly react with silyl enol ethers at low temperature to afford the corresponding oxoketene dithioacetal ad...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff780510eb3b94ae5b15e91aa544c2e9
https://doi.org/10.1246/cl.1987.1691
https://doi.org/10.1246/cl.1987.1691
Publikováno v:
Chemistry Letters. 16:1695-1698
In the presence of a catalytic amount of trityl salt, allylstannanes and stannylated enolates smoothly react with 2-(2-ethylthioalkylidene)-1,3-dithiolane, synthetic equivalent of α,β-unsaturated ester, to afford the corresponding adducts in good y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b6acca86e92e130642f914e32d6157
https://doi.org/10.1246/cl.1987.1695
https://doi.org/10.1246/cl.1987.1695