Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Hiroyuki, Seimiya"'
Autor:
Masatomo Chiba, Kenichi Miyata, Hikaru Okawa, Yoko Tanaka, Koji Ueda, Hiroyuki Seimiya, Akiko Takahashi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16399 (2023)
Senescent cells secrete inflammatory proteins and small extracellular vesicles (sEVs), collectively termed senescence-associated secretory phenotype (SASP), and promote age-related diseases. Epigenetic alteration in senescent cells induces the expres
Externí odkaz:
https://doaj.org/article/652f53f7d49242609024e8301c90eada
Autor:
Tetsuo Mashima, Takeru Wakatsuki, Naomi Kawata, Myung-Kyu Jang, Akiko Nagamori, Haruka Yoshida, Kenichi Nakamura, Toshiro Migita, Hiroyuki Seimiya, Kensei Yamaguchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) axis is an essential regulator of angiogenesis and important therapeutic target in cancer. Ramucirumab is an anti-VEGFR2 monoclonal antibody used for the treatment of severa
Externí odkaz:
https://doaj.org/article/422426adde034efd8700a487b51f4081
Autor:
Chiaki Fujiwara, Yukiko Muramatsu, Megumi Nishii, Kazuhiro Tokunaka, Hidetoshi Tahara, Masaru Ueno, Takao Yamori, Yoshikazu Sugimoto, Hiroyuki Seimiya
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Telomere maintenance by telomerase activity supports the infinite growth of cancer cells. MST-312, a synthetic telomerase inhibitor, gradually shortens telomeres at non-acute lethal doses and eventually induces senescence and apoptosis of te
Externí odkaz:
https://doaj.org/article/bcff0d57a37a40e7bac59241a17f8c5f
Autor:
Takahiro Nakamura, Sachiko Okabe, Haruka Yoshida, Keisuke Iida, Yue Ma, Shogo Sasaki, Takao Yamori, Kazuo Shin-ya, Ichiro Nakano, Kazuo Nagasawa, Hiroyuki Seimiya
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract G-quadruplex (G4) is a higher-order nucleic acid structure that is formed by guanine-rich sequences. G4 stabilization by small-molecule compounds called G4 ligands often causes cytotoxicity, although the potential medicinal impact of this ef
Externí odkaz:
https://doaj.org/article/3aa433890e6a4fbf9414876c5f696dba
Autor:
Caroline Moyret‐Lalle, Mélanie K. Prodhomme, Delphine Burlet, Ayaka Kashiwagi, Virginie Petrilli, Alain Puisieux, Hiroyuki Seimiya, Agnès Tissier
Publikováno v:
Cancer Science. 113:2214-2223
Numerous epithelial-mesenchymal transition (EMT) characteristics have now been demonstrated to participate in tumor development. Indeed, EMT is involved in invasion, acquisition of stem cell properties, and therapy-associated resistance of cancer cel
Autor:
Hiroyuki Seimiya, Yoshikazu Sugimoto, Naoya Fujita, Satoshi Nagayama, Ryohei Katayama, Masaaki Matsuura, Kento Nakata, Yukiko Muramatsu, Haruka Yoshida, Bo Gong, Aki Aoyama, Ayana Sato, Anna Mizutani, Tetsuo Mashima, Noritaka Tanaka
In most colorectal cancers, Wnt/β-catenin signaling is activated by loss-of-function mutations in the adenomatous polyposis coli (APC) gene and plays a critical role in tumorigenesis. Tankyrases poly(ADP-ribosyl)ate and destabilize Axins, a negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8058dabfd4016a1add46858c13f4ab3e
https://doi.org/10.1158/1535-7163.c.6538768
https://doi.org/10.1158/1535-7163.c.6538768
Supplementary Material and Methods, Supplementary References, Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305fcf2948acd9a1010e6e26902fe2fa
https://doi.org/10.1158/1535-7163.22521414.v1
https://doi.org/10.1158/1535-7163.22521414.v1
Autor:
Hiroyuki Seimiya, Yoshikazu Sugimoto, Naoya Fujita, Satoshi Nagayama, Ryohei Katayama, Masaaki Matsuura, Kento Nakata, Yukiko Muramatsu, Haruka Yoshida, Bo Gong, Aki Aoyama, Ayana Sato, Anna Mizutani, Tetsuo Mashima, Noritaka Tanaka
Supplementary Figure S1: Full scans of the immunoblots shown in Figs. 1C, 2A and 4A. Supplementary Figure S2: Basal expression of tankyrase, Axins, and β-catenin and intracellular localization of β-catenin in CRC cell lines used in this study. Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae13bad0fba3f6dc4a70c7ff8b0ef43
https://doi.org/10.1158/1535-7163.22507726.v1
https://doi.org/10.1158/1535-7163.22507726.v1
Autor:
Hiroyuki Seimiya, Yoshikazu Sugimoto, Naoya Fujita, Satoshi Nagayama, Ryohei Katayama, Masaaki Matsuura, Kento Nakata, Yukiko Muramatsu, Haruka Yoshida, Bo Gong, Aki Aoyama, Ayana Sato, Anna Mizutani, Tetsuo Mashima, Noritaka Tanaka
Legends for Supplementary Figure S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c208e1d39930ee1ab90fbc4958f76a
https://doi.org/10.1158/1535-7163.22507732.v1
https://doi.org/10.1158/1535-7163.22507732.v1
Autor:
Hiroyuki Seimiya, Yoshikazu Sugimoto, Naoya Fujita, Satoshi Nagayama, Ryohei Katayama, Masaaki Matsuura, Kento Nakata, Yukiko Muramatsu, Haruka Yoshida, Bo Gong, Aki Aoyama, Ayana Sato, Anna Mizutani, Tetsuo Mashima, Noritaka Tanaka
Multiple regression analysis of tankyrase inhibitor sensitivities and genetic mutations in colorectal cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf039b732b086df7e454dda2d5cb49a
https://doi.org/10.1158/1535-7163.22507720.v1
https://doi.org/10.1158/1535-7163.22507720.v1