Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Hiroyuki, Sasanuma"'
Autor:
Akiko Tomita, Hiroyuki Sasanuma, Tomoo Owa, Yuka Nakazawa, Mayuko Shimada, Takahiro Fukuoka, Tomoo Ogi, Shinichiro Nakada
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract CRISPR/Cas9-mediated gene editing has great potential utility for treating genetic diseases. However, its therapeutic applications are limited by unintended genomic alterations arising from DNA double-strand breaks and random integration of
Externí odkaz:
https://doaj.org/article/fd19774db06e4eaea5b2aee8e58463e9
Autor:
Rifat Ara Najnin, Md Rasel Al Mahmud, Md Maminur Rahman, Shunichi Takeda, Hiroyuki Sasanuma, Hisashi Tanaka, Yasuhiro Murakawa, Naoto Shimizu, Salma Akter, Masatoshi Takagi, Takuro Sunada, Shusuke Akamatsu, Gang He, Junji Itou, Masakazu Toi, Mary Miyaji, Kimiko M. Tsutsui, Scott Keeney, Shintaro Yamada
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111909- (2023)
Summary: ATM gene mutation carriers are predisposed to estrogen-receptor-positive breast cancer (BC). ATM prevents BC oncogenesis by activating p53 in every cell; however, much remains unknown about tissue-specific oncogenesis after ATM loss. Here, w
Externí odkaz:
https://doaj.org/article/fc73a448f05d4c34af1641771aac7840
Autor:
Takahito Moriwaki, Akari Yoshimura, Yuki Tamari, Hiroyuki Sasanuma, Shunichi Takeda, Masayuki Seki, Keizo Tano
Publikováno v:
Genes and Environment, Vol 43, Iss 1, Pp 1-8 (2021)
Abstract Background Peroxiredoxin 1 (PRDX1) is a member of a ubiquitous family of thiol peroxidases that catalyze the reduction of peroxides, including hydrogen peroxide. It functions as an antioxidant enzyme, similar to catalase and glutathione pero
Externí odkaz:
https://doaj.org/article/cc54a72e066c49a69556b929e338d33e
Autor:
Shin-Ya Isobe, Shin-ichiro Hiraga, Koji Nagao, Hiroyuki Sasanuma, Anne D. Donaldson, Chikashi Obuse
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109383- (2021)
Summary: DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining (NHEJ) or homologous recombination (HR). RIF1 negatively regulates resection through the effector Shieldin, which associates with a short 3′ single-stranded
Externí odkaz:
https://doaj.org/article/4755f742828b4ed48e35afdcc3b31afd
Autor:
Maki Sakurada-Aono, Takashi Sakamoto, Masayuki Kobayashi, Yoko Takiuchi, Fumie Iwai, Kohei Tada, Hiroyuki Sasanuma, Shigeki Hirabayashi, Yasuhiro Murakawa, Kotaro Shirakawa, Chihiro Sakamoto, Keisuke Shindo, Jun-ichirou Yasunaga, Masao Matsuoka, Yves Pommier, Shunichi Takeda, Akifumi Takaori-Kondo
Publikováno v:
Biochemical and Biophysical Research Communications. 657:43-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96eb73327911086cbb73fe01ee6a2f7d
https://doi.org/10.1016/j.bbrc.2023.03.049
https://doi.org/10.1016/j.bbrc.2023.03.049
Autor:
Fumiya Moribe, Momoko Nishikori, Tsuyoshi Takashima, Daiki Taniyama, Nobuyuki Onishi, Hiroshi Arima, Hiroyuki Sasanuma, Remi Akagawa, Fathi Elloumi, Shunichi Takeda, Yves Pommier, Eiichi Morii, Akifumi Takaori-Kondo, Junko Murai
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0237554 (2021)
BackgroundSLFN11 has recently been reported to execute cancer cells harboring replicative stress induced by DNA damaging agents. However, the roles of SLFN11 under physiological conditions remain poorly understood. Germinal center B-cells (GCBs) unde
Externí odkaz:
https://doaj.org/article/bd3783f480924af5b7bd34d5f263915e
Autor:
Remi Akagawa, Hai Thanh Trinh, Liton Kumar Saha, Masataka Tsuda, Kouji Hirota, Shintaro Yamada, Atsushi Shibata, Masato T. Kanemaki, Shinichiro Nakada, Shunichi Takeda, Hiroyuki Sasanuma
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: Chemical modifications and adducts at DNA double-strand break (DSB) ends must be cleaned before re-joining by non-homologous end-joining (NHEJ). MRE11 nuclease is essential for efficient removal of Topoisomerase II (TOP2)-DNA adducts from TO
Externí odkaz:
https://doaj.org/article/8b99c7ff8a274e088ee42c1362159c13
Autor:
Junji Itou, Rei Takahashi, Hiroyuki Sasanuma, Masataka Tsuda, Suguru Morimoto, Yoshiaki Matsumoto, Tomoko Ishii, Fumiaki Sato, Shunichi Takeda, Masakazu Toi
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: Mammary ductal dysplasia is a phenotype observed in precancerous lesions and early-stage breast cancer. However, the mechanism of dysplasia formation remains elusive. Here we show, by establishing a novel dysplasia model system, that estroge
Externí odkaz:
https://doaj.org/article/12ed23d1aa764d119b849635754a8ac5
Autor:
Toshiaki Nakano, Mahmoud I Shoulkamy, Masataka Tsuda, Hiroyuki Sasanuma, Kouji Hirota, Minoru Takata, Shin-Ichiro Masunaga, Shunichi Takeda, Hiroshi Ide, Tadayoshi Bessho, Keizo Tano
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234859 (2020)
Proteins are covalently trapped on DNA to form DNA-protein cross-links (DPCs) when cells are exposed to DNA-damaging agents. Aldehyde compounds produce common types of DPCs that contain proteins in an undisrupted DNA strand. Tyrosyl-DNA phosphodieste
Externí odkaz:
https://doaj.org/article/e46da9f5427340498e7c36d9b12cb89d
Autor:
Ayuna Takeishi, Hiroyuki Kogashi, Mizuki Odagiri, Hiroyuki Sasanuma, Shunichi Takeda, Manabu Yasui, Masamitsu Honma, Tetsuya Suzuki, Hiroyuki Kamiya, Kaoru Sugasawa, Kiyoe Ura, Akira Sassa
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244790 (2020)
Ribonucleoside triphosphates are often incorporated into genomic DNA during DNA replication. The accumulation of unrepaired ribonucleotides is associated with genomic instability, which is mediated by DNA topoisomerase 1 (Top1) processing of embedded
Externí odkaz:
https://doaj.org/article/d653b045ca4047c8bc158c4aafc822ad