Zobrazeno 1 - 10
of 742
pro vyhledávání: '"Hiroyuki, Saito"'
Autor:
Serina Gima, Kazuya Oe, Kaneyasu Nishimura, Takashi Ohgita, Haruka Ito, Hiroyuki Kimura, Hiroyuki Saito, Kazuyuki Takata
Publikováno v:
Regenerative Therapy, Vol 25, Iss , Pp 229-237 (2024)
Introduction: Cell therapeutic clinical trials using fetal mesencephalic tissue provided a proof-of-concept for regenerative therapy in patients with Parkinson's disease. Postmortem studies of patients with fetal grafts revealed that α-synuclein+ Le
Externí odkaz:
https://doaj.org/article/d10ffc09f08546f48fc70c58246c770c
Autor:
Zhiming Shen, Hiroyuki Saito, Wataru Mita, Takeshi Fujihara, Hong-Baek Cho, Tadachika Nakayama
Publikováno v:
Science and Technology of Advanced Materials, Vol 25, Iss 1 (2024)
ABSTRACTThe fillers inside a polymer matrix should typically be self-assembled in both the horizontal and vertical directions to obtain 3-dimentional (3D) percolation pathways, whereby the fields of application can be expanded and the properties of o
Externí odkaz:
https://doaj.org/article/1c18719f14f643e3ac2a59c09bbdb338
Autor:
Yuki Takechi-Haraya, Takashi Ohgita, Akiko Usui, Kazuchika Nishitsuji, Kenji Uchimura, Yasuhiro Abe, Ryuji Kawano, Monika I. Konaklieva, Mart Reimund, Alan T. Remaley, Yoji Sato, Ken-ichi Izutsu, Hiroyuki Saito
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Amphipathic arginine-rich peptide, A2-17, exhibits moderate perturbation of lipid membranes and the highest cell penetration among its structural isomers. We investigated the direct cell-membrane penetration mechanism of the A2-17 peptide wh
Externí odkaz:
https://doaj.org/article/b8893099f948499b954ee0db0b116037
Autor:
Norihiro Namba, Takashi Ohgita, Hiroko Tamagaki-Asahina, Kazuchika Nishitsuji, Toshinori Shimanouchi, Takeshi Sato, Hiroyuki Saito
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The N-terminal fragment of apolipoprotein A-I (apoA-I), comprising residues 1–83, contains three segments prone to aggregation: residues 14–22, 53–58, and 67–72. We previously demonstrated that residues 14–22 are critical in apoA-I
Externí odkaz:
https://doaj.org/article/21de3cc37573420ebf053c4f5b2d5d94
Autor:
Yoko Shibata, Kenji Omae, Hiroyuki Minemura, Yasuhito Suzuki, Takefumi Nikaido, Yoshinori Tanino, Atsuro Fukuhara, Ryuzo Kanno, Hiroyuki Saito, Shuzo Suzuki, Taeko Ishii, Yayoi Inokoshi, Eiichiro Sando, Hirofumi Sakuma, Tatsuho Kobayashi, Hiroaki Kume, Masahiro Kamimoto, Hideko Aoki, Akira Takama, Takamichi Kamiyama, Masaru Nakayama, Kiyoshi Saito, Koichi Tanigawa, Masahiko Sato, Toshiyuki Kambe, Norio Kanzaki, Teruhisa Azuma, Keiji Sakamoto, Yuichi Nakamura, Hiroshi Ohtani, Mitsuru Waragai, Shinsaku Maeda, Tokiya Ishida, Keishi Sugino, Minoru Inage, Noriyuki Hirama, Kodai Furuyama, Shigeyuki Fukushima, Hiroshi Saito, Jun-ichi Machiya, Hiroyoshi Machida, Koya Abe, Katsuyoshi Iwabuchi, Yuji Katagiri, Yasuko Aida, Yuki Abe, Takahito Ota, Yuki Ishizawa, Yasuhiko Tsukada, Ryuki Yamada, Riko Sato, Takumi Onuma, Hikaru Tomita, Mikako Saito, Natsumi Watanabe, Mami Rikimaru, Takaya Kawamata, Takashi Umeda, Julia Morimoto, Ryuichi Togawa, Yuki Sato, Junpei Saito, Kenya Kanazawa, Noriaki Kurita, Ken Iseki
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background During the fifth wave of the coronavirus disease 2019 (COVID-19) pandemic in Japan, which took place between June and September 2021, a significant number of COVID-19 cases with deterioration occurred in unvaccinated individuals
Externí odkaz:
https://doaj.org/article/ed1ff4d1c8274dfaab28462e42eb1044
Autor:
Takashi Ohgita, Hiroki Kono, Izumi Morita, Hiroyuki Oyama, Toshinori Shimanouchi, Norihiro Kobayashi, Hiroyuki Saito
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Regulation of α-synuclein (αS) fibril formation is a potent therapeutic strategy for αS-related neurodegenerative disorders. αS, an intrinsically disordered 140-residue intraneural protein, comprises positively charged N-terminal, hydrop
Externí odkaz:
https://doaj.org/article/10610d7d92d34ae0ab1fa5b064e5d988
Physicochemical mechanisms of aggregation and fibril formation of α-synuclein and apolipoprotein A-I
Publikováno v:
Biophysics and Physicobiology, Vol 21 (2024)
Deposition and accumulation of amyloid fibrils is a hallmark of a group of diseases called amyloidosis and neurodegenerative disorders. Although polypeptides potentially have a fibril-forming propensity, native proteins have evolved into proper funct
Externí odkaz:
https://doaj.org/article/d13d7740fe024887b8ceab8dd72a08dd
Autor:
Sunao Wada, MH Mahbub, Natsu Yamaguchi, Ryosuke Hase, Yuki Nakagami, Hidekazu Takahashi, Hiroyuki Saito, Junki Shimokawa, Rie Watanabe, Tsuyoshi Tanabe
Publikováno v:
Journal of Advanced Biotechnology and Experimental Therapeutics, Vol 6, Iss 1, Pp 222-230 (2023)
Exercise training has the potential for inducing enhancements in peripheral circulation, which can play important preventive and therapeutic roles in peripheral circulatory diseases. However, the relevant published studies show conflicting and inconc
Externí odkaz:
https://doaj.org/article/5d2bb7979105403c9ab03c1b0ae6199c
Autor:
Hiroyuki Saito, Takeshi Hiramatsu
Publikováno v:
Tokyo Women's Medical University Journal, Vol 6, Iss 0, Pp 145-148 (2022)
Simple ascending aortic replacement is the gold standard for emergency surgery in patients with type A acute aortic dissection (TA-AAD). Some patients require a second intervention because of the aortic arch expansion. Zone 0 thoracic endovascular an
Externí odkaz:
https://doaj.org/article/c3c38f3875d9498faa326aa046f75dce
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Aggregation of α-synuclein (α-syn) into amyloid fibrils is closely associated with Parkinson’s disease (PD). Familial mutations or posttranslational truncations in α-syn are known as risk factor for PD. Here, we examined the effects of
Externí odkaz:
https://doaj.org/article/b3dd587cc08b479c92d22703bf774068