Zobrazeno 1 - 10
of 729
pro vyhledávání: '"Hiroyuki, SASAKI"'
Autor:
Hidehiro Toh, Hiroaki Okae, Kenjiro Shirane, Tetsuya Sato, Hirotaka Hamada, Chie Kikutake, Daisuke Saito, Takahiro Arima, Hiroyuki Sasaki, Mikita Suyama
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background The placenta is essential for nutrient exchange and hormone production between the mother and the developing fetus and serves as an invaluable model for epigenetic research. Most epigenetic studies of the human placenta have used
Externí odkaz:
https://doaj.org/article/38a1cd4b425b42a799cbcef9e883d6e7
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract DNA methyltransferase 3A (DNMT3A) and its catalytically inactive cofactor DNA methyltransferase 3-Like (DNMT3L) proteins form functional heterotetramers to deposit DNA methylation in mammalian germ cells. While both proteins have an ATRX-DNM
Externí odkaz:
https://doaj.org/article/5dfd2b7a13884f8087db47cfaa362e8a
Autor:
Keisuke Toriyama, Wan Kin Au Yeung, Azusa Inoue, Kazuki Kurimoto, Yukihiro Yabuta, Mitinori Saitou, Toshinobu Nakamura, Toru Nakano, Hiroyuki Sasaki
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Genome-wide DNA demethylation occurs in mammalian primordial germ cells (PGCs) as part of the epigenetic reprogramming important for gametogenesis and resetting the epigenetic information for totipotency. Dppa3 (also known as Stel
Externí odkaz:
https://doaj.org/article/00e65864e7a743a1982400d04bcbce0c
Autor:
Mizuki Sakamoto, Aoi Ito, Sayaka Wakayama, Hiroyuki Sasaki, Teruhiko Wakayama, Takashi Ishiuchi
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114118- (2024)
Summary: Zygotic genome activation (ZGA) after fertilization enables the maternal-to-zygotic transition. However, the global view of ZGA, particularly at initiation, is incompletely understood. Here, we develop a method to capture and sequence newly
Externí odkaz:
https://doaj.org/article/9ed8ec9cff2f42ee8f95fda64a19b2b8
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background Epigenetic modifications established in mammalian gametes are largely reprogrammed during early development, however, are partly inherited by the embryo to support its development. In this study, we examine CpG island (CGI) sequen
Externí odkaz:
https://doaj.org/article/2368566fd5e84a869956acc7c60ac72e
Autor:
Junko Okuyama, Shin-Ichi Izumi, Shunichi Funakoshi, Shuji Seto, Hiroyuki Sasaki, Kiyoshi Ito, Fumihiko Imamura, Mayumi Willgerodt, Yu Fukuda
Publikováno v:
Humanities & Social Sciences Communications, Vol 9, Iss 1, Pp 1-13 (2022)
Abstract Historical data can determine how adolescents recover from difficult situations such as the Coronavirus disease 2019 (COVID-19) pandemic. This study analysed 3 years of data obtained from high-school students who had been affected by the 201
Externí odkaz:
https://doaj.org/article/1411f6d0230d49758d88c70142cb8d99
Autor:
Seiichi Yano, Takashi Ishiuchi, Shusaku Abe, Satoshi H. Namekawa, Gang Huang, Yoshihiro Ogawa, Hiroyuki Sasaki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
DNMT3A is known to methylate DNA at histone H3 lysine 36 (H3K36me3)-marked transcriptionally active regions in mouse oocytes. Here the authors show that DNMT3A is also guided by H3K36me2 to methylate broad domains in genic and intergenic loci, as wel
Externí odkaz:
https://doaj.org/article/d14052d145fd491295690d0b53f6bf95
Autor:
Shintaro Kamijo, Toshio Hamatani, Hiroyuki Sasaki, Hiroki Suzuki, Akane Abe, Osamu Inoue, Maki Iwai, Seiji Ogawa, Kei Odawara, Kanako Tanaka, Mutsumi Mikashima, Masami Suzuki, Kenji Miyado, Ryo Matoba, Yasushi Odawara, Mamoru Tanaka
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-10 (2022)
Abstract Objective To generate an effective embryo prediction model and identify a non-invasive evaluation method by analyzing microRNAs (miRNAs) in embryo culture medium. Design Analysis of microRNA profiles from spent culture medium of blastocysts
Externí odkaz:
https://doaj.org/article/87dd0ffc1e6d4ca8962e4217c59bed39
Autor:
Kaede Ito, Atsushi Haraguchi, Shuhei Sato, Masataka Sekiguchi, Hiroyuki Sasaki, Conn Ryan, Yijin Lyu, Shigenobu Shibata
Publikováno v:
Frontiers in Microbiomes, Vol 2 (2023)
Consuming resistant maltodextrin (RMD) decreases food intake and increase appetite-related gut hormones, but the underlying mechanisms have remained unknown. Therefore, we aimed to elucidate the mechanisms underlying the effects of RMD feeding on foo
Externí odkaz:
https://doaj.org/article/d7ebe1f6157a4f538eaa330a2f7765a4
Autor:
Hiroyuki Sasaki, Tadashi Jono, Ryuji Fukuhara, Kazuki Honda, Tomohisa Ishikawa, Shuken Boku, Minoru Takebayashi
Publikováno v:
BMC Psychiatry, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background The age of attention-deficit/hyperactivity disorder onset is usually during the first 12 years of life; however, there have been recent reports of late-onset attention-deficit/hyperactivity disorder. These reports have been limite
Externí odkaz:
https://doaj.org/article/bce05f90e2474c9fae543415dff18e10