Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hiroyoshi Y. Tanaka"'
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Autor:
Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nanoparticle delivery of siRNA has problems with penetration and off target accumulation. Here, the authors report on the development of Y-shaped block catiomers which dynamically wrap around siRNA; demonstrate increased circulation times and deliver
Externí odkaz:
https://doaj.org/article/e56544229bd24572b3344d7cb418ce63
Autor:
Chiharu Morii, Hiroyoshi Y. Tanaka, Yasuhisa Izushi, Natsumi Nakao, Masaya Yamamoto, Hiromi Matsubara, Mitsunobu R. Kano, Aiko Ogawa
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
In pulmonary arterial hypertension (PAH), excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) causes vascular medial thickening. Medial thickening is a histopathological hallmark of pulmonary vascular remodeling, the central dise
Externí odkaz:
https://doaj.org/article/24ed040cdf1846b89c7bef4e59734077
Autor:
Hiroyoshi Y. Tanaka, Mitsunobu R. Kano
Publikováno v:
Drug Delivery System. 36:232-240
Autor:
Hiroyoshi Y. Tanaka
Publikováno v:
YAKUGAKU ZASSHI. 141:647-653
Remarkable progress in our ability to analyze diseased tissue has revolutionized our understanding of disease. From a simplistic understanding of abnormalities in bulk tissue, there is now increasing recognition that the heterogeneous and dynamically
Autor:
Ayako Ohshima, Kazuaki Shinomiya, Shiro Hinotsu, Toshihiro Koyama, Yoshihisa Kitamura, Toshiaki Sendo, Yusuke Teratani, Tomoko Funahashi, Hiroyoshi Y. Tanaka, Mayu Adachi, Yasuhisa Tatebe, Ken Tasaka, Hideharu Hagiya, Mitsunobu R. Kano, Yoshito Zamami
Publikováno v:
Journal of Infection and Chemotherapy. 26:660-666
Appropriate antibiotic prescriptions for outpatients with acute respiratory tract infections (ARTIs) are urgently needed in Japan. However, the empirical proof of this need is under-documented. Therefore, we aimed to determine antibiotic prescription
Publikováno v:
Cancers. 15:724
Simple Summary Pancreatic cancer is difficult to treat. Novel treatment strategies are urgently needed to improve the survival rate, which is approximately 10% five years after diagnosis. The use of nanomedicines, which are formulated within a charac
Autor:
Toshiaki Sendo, Mitsunobu R. Kano, Michael W Miller, Hiroyoshi Y. Tanaka, Ayako Ohshima, Aiko Ogawa, Shiro Hinotsu, Toshihiro Koyama, Yoshito Zamami, Yoshihisa Kitamura
Publikováno v:
Family Practice. 36:685-692
Background Oral anticoagulants use has increased rapidly, internationally. Here we look at risks and benefits, based on Japanese data, of therapy with low risk non-valvular atrial fibrillation patients. Objectives Using a health insurance claims data
Autor:
Hiroshi Nishihara, Atsushi Masamune, Kae Sato, Naoki Sasaki, Hiroyoshi Y. Tanaka, Hirokazu Narita, Michiya Matsusaki, Natsumi Nakao, Mitsunobu R. Kano, Hiroshi Shimoda, Kentaro Kitahara
Publikováno v:
Biomaterials. 192:355-367
Desmoplasia is a hallmark of pancreatic cancer and consists of fibrotic cells and secreted extracellular matrix (ECM) components. Various in vitro three-dimensional (3D) models of desmoplasia have been reported, but little is known about the relevant
Autor:
Chiharu, Morii, Hiroyoshi Y, Tanaka, Yasuhisa, Izushi, Natsumi, Nakao, Masaya, Yamamoto, Hiromi, Matsubara, Mitsunobu R, Kano, Aiko, Ogawa
Publikováno v:
Frontiers in Bioengineering and Biotechnology
In pulmonary arterial hypertension (PAH), excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) causes vascular medial thickening. Medial thickening is a histopathological hallmark of pulmonary vascular remodeling, the central dise
Autor:
Mitsunobu R. Kano, Atsushi Masamune, Takuya Nakazawa, Michiya Matsusaki, Tsuyoshi Kurihara, Hiroyoshi Y. Tanaka
Publikováno v:
Biomaterials. 251
Pancreatic ductal adenocarcinoma (PDAC) is an often lethal disease characterized by a dense, fibrotic stroma. However, the lack of relevant preclinical models that recapitulate the characteristic histopathology of human PDAC in vitro impedes the deve