Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hiroyoshi Kawada"'
Autor:
Peter F Kador, Peng Zhang, Jun Makita, Zifeng Zhang, Changmei Guo, James Randazzo, Hiroyoshi Kawada, Neena Haider, Karen Blessing
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e49422 (2012)
Mouse models possessing green fluorescent protein (GFP) and/or human aldose reductase (hAR) in vascular tissues have been established and crossed with naturally diabetic Akita mice to produce new diabetic mouse models.Colonies of transgenic C57BL mic
Externí odkaz:
https://doaj.org/article/f78f137389ec4472a66891a5e4d1d28d
Autor:
James Randazzo, Zifeng Zhang, Michael Hoff, Hiroyoshi Kawada, Andrew Sachs, Yang Yuan, Neena Haider, Peter Kador
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21926 (2011)
Progression of age-related macular degeneration has been linked to iron dysregulation and oxidative stress that induce apoptosis of neural retinal cells. Since both antioxidants and chelating agents have been reported to reduce the progression of ret
Externí odkaz:
https://doaj.org/article/4434c883595d40e9a7ded3ef7747939f
Autor:
Karen Blessing, Hiroyoshi Kawada, Tomomi Kiyota, Peter F. Kador, Lee C. Winchester, Theodor A Woolman
Publikováno v:
Journal of Alzheimer's Disease. 44:297-307
Background Redox-active metal dyshomeostasis and oxidative stress are associated with mitochondrial dysfunction and amyloid-β (Aβ) neurotoxicity that are linked to both the development of age-related macular degeneration (AMD) and Alzheimer's disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e5b3c234f3381eaac93ed44daf751e
https://doi.org/10.3233/jad-132471
https://doi.org/10.3233/jad-132471
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 30:593-602
Based on the hypothesis that oral nutraceuticals do not adequately reach all ocular tissues in the anterior segment, we evaluated the ability of a 3% concentration of the ingredients in a topical nutraceutical antioxidant formulation called Optixcare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70180c474abf42c173bd03f6a610e3ab
https://doi.org/10.1089/jop.2014.0016
https://doi.org/10.1089/jop.2014.0016
Autor:
Karen Blessing, Zifeng Zhang, Changmei Guo, Peng Zhang, Peter F. Kador, Hiroyoshi Kawada, Jun Makita
Publikováno v:
Experimental Eye Research. 119:77-87
Retinal capillary pericyte degeneration has been linked to aldose reductase (AR) activity in diabetic retinopathy (DR). Since the development of DR in mice and rats has been reported to differ and that this may be linked to differences in retinal sor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b14d867edbc4e86557fe9b135a1dde6
https://doi.org/10.1016/j.exer.2013.12.009
https://doi.org/10.1016/j.exer.2013.12.009
Autor:
Hiroyoshi Kawada, Peter F. Kador
Publikováno v:
Journal of medicinal chemistry. 58(22)
Neurodegenerative diseases are associated with oxidative stress that is induced by the presence of reactive oxygen species and the abnormal cellular accumulation of transition metals. Here, a new series of orally bioavailable multifunctional antioxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb5c147d93c72dcf7921bf64297821c
https://pubmed.ncbi.nlm.nih.gov/26068053
https://pubmed.ncbi.nlm.nih.gov/26068053
Autor:
Magoichi Sako, Hiroyoshi Kawada
Publikováno v:
The Journal of Organic Chemistry. 69:8148-8150
The treatment of (15)N(4)-labeled cytidine N(3)-oxide and (15)N(4)-labeled 2'-deoxycytidine N(3)-oxide, prepared from the appropriate unprotected uridines in three reaction steps, with benzyl bromide in the presence of excess lithium methoxide allowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b129df51be6a66fa42eccadc62f29fd6
https://doi.org/10.1021/jo0486241
https://doi.org/10.1021/jo0486241
Autor:
Peng Zhang, Zifeng Zhang, Hiroyoshi Kawada, Peter F. Kador, Changmei Guo, James Randazzo, Neena B. Haider, Karen Blessing, Jun Makita
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e49422 (2012)
PLoS ONE
PLoS ONE
Objective Mouse models possessing green fluorescent protein (GFP) and/or human aldose reductase (hAR) in vascular tissues have been established and crossed with naturally diabetic Akita mice to produce new diabetic mouse models. Research Design and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361f4cd35692af342238e451a9e2c14f
http://europepmc.org/articles/PMC3520987?pdf=render
http://europepmc.org/articles/PMC3520987?pdf=render
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5adfa21937d29e1969a0c2ceb73a902
https://doi.org/10.1002/chin.199951214
https://doi.org/10.1002/chin.199951214
Publikováno v:
The Journal of Organic Chemistry. 64:5719-5721
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9868859589a0b8e91cb4372e0e119340
https://doi.org/10.1021/jo990500e
https://doi.org/10.1021/jo990500e