Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

Autor: Junji Ishida, Satoru Takahashi, Kazuya Murata, Masafumi Muratani, Yoko Daitoku, Yuko Hamada, Hayate Suzuki, Akiyoshi Fukamizu, Tra Thi Huong Dinh, Masatsugu Ema, Ken-ichi Yagami, Hiroyoshi Iseki, Ammar Shaker Hamed Hasan, Kanako Kato, Valerie Wilson, Jun-Dal Kim, Mitsuyasu Kato, Ruth M. Arkell, Seiya Mizuno, Yoko Tanimoto, Saori Iijima-Mizuno, Fumihiro Sugiyama

Publikováno v: eLife, Vol 10 (2021)
Dinh, T T H, Iseki, H, Mizuno, S, Lijima-Mizuno, S, Tanimoto, Y, Daitoku, Y, Kato, K, Hamada, Y, Hasan, A S H, Suzuki, H, Murata, K, Muratani, M, Ema, M, Kim, J-D, Ishida, J, Fukamizu, A, Kato, M, Takahashi, S, Yagami, K, Wilson, V, Arkell, R M & Sugiyama, F 2021, ' Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway ', eLIFE, vol. 10, e50346 . https://doi.org/10.7554/eLife.50346

In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entireCables2locus (Cables2d) caused growth retardation and enhanced apoptosis at the ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58aa969e49b4ef64147f91278c75d596
https://elifesciences.org/articles/50346

Cables2 Is a Novel Smad2-Regulatory Factor Essential for Early Embryonic Development in Mice

Autor: Masafumi Muratani, Valerie Wilson, Junji Ishida, Kazuya Murata, Seiya Mizuno, Satoru Takahashi, Saori Iijima-Mizuno, Ammar Shaker Hamed Hasan, Yuko Hamada, Jun-Dal Kim, Hayate Suzuki, Akiyoshi Fukamizu, Yoko Tanimoto, Ken-ichi Yagami, Yoko Daitoku, Mitsuyasu Kato, Ruth M. Arkell, Kanako Kato, Fumihiro Sugiyama, Hiroyoshi Iseki, Masatsugu Ema, Tra Thi Huong Dinh

CDK5 and Abl enzyme substrate 2 (Cables2), a member of the Cables family that has a C-terminal cyclin box-like domain, is widely expressed in adult mouse tissues. However, the physiological role of Cables2in vivois unknown. We show here thatCables2-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75aa0af97d81a1976a086c53accc9f86

Germline recombination in a novel Cre transgenic line,Prl3b1-Cre mouse

Autor: Abdelaziz E. Ibrahim, Youhei Hiromori, Megumi C. Katoh, Tsuyoshi Nakanishi, Hisashi Oishi, Al-Sayed Al-Soudy, Seiya Mizuno, Fumihiro Sugiyama, Atsushi Yoshiki, Walaa A Basha, Hossam H. Shawki, Satoru Takahashi, Yoshikazu Hasegawa, Hany A. El-Shemy, Hiroyoshi Iseki, Hisamitsu Nagase

Publikováno v: genesis. 54:389-397

Spermatogenesis is a complex and highly regulated process by which spermatogonial stem cells differentiate into spermatozoa. To better understand the molecular mechanisms of the process, the Cre/loxP system has been widely utilized for conditional ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a090c1807f9decef993b8d701af54f42
https://doi.org/10.1002/dvg.22944

Truncated Cables1 causes agenesis of the corpus callosum in mice

Autor: Dinh T H Tra, Akiyoshi Fukamizu, Atsushi Mizobuchi, Junji Ishida, Fumihiro Sugiyama, Yoichi Matsuda, Saori Mizuno-Iijima, Ken-ichi Yagami, Hiroyoshi Iseki, Jun-Dal Kim, Satoshi Kunita, Seiya Mizuno

Publikováno v: Laboratory Investigation. 94:321-330

Agenesis of the corpus callosum (ACC) is a congenital abnormality of the brain structure. More than 60 genes are known to be involved in corpus callosum development. However, the molecular mechanisms underlying ACC are not fully understood. Previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded4ed175b946ab2bf01f9ffaf7136f7
https://doi.org/10.1038/labinvest.2013.146

Sirt1, p53, and p38 MAPK Are Crucial Regulators of Detrimental Phenotypes of Embryonic Stem Cells with Max Expression Ablation

Autor: Yutaka Nakachi, Yosuke Mizuno, Masayoshi Kamon, Miyuki Katano, Akihiko Okuda, Yasushi Okazaki, Tomoaki Hishida, Masazumi Nishimoto, Masataka Hirasaki, Yuriko Nozaki, Hiroyoshi Iseki

Publikováno v: STEM CELLS. 30:1634-1644

c-Myc participates in diverse cellular processes including cell cycle control, tumorigenic transformation, and reprogramming of somatic cells to induced pluripotent cells. c-Myc is also an important regulator of self-renewal and pluripotency of embry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c271c865a93b06bd663a8da90864f9
https://doi.org/10.1002/stem.1147