Zobrazeno 1 - 10
of 649
pro vyhledávání: '"Hiroyoshi, Hidaka"'
Autor:
Paul J. Hartman, David L. Cooke, Henry H. Hsu, Jeanette Stewart, Kengo Sumi, Yoko Yoshida, Hiroyoshi Hidaka, Gary D. Novack
Publikováno v:
Ophthalmology. Glaucoma, vol 6, iss 2
PurposeTo perform a phase Ⅰ/Ⅱ evaluation of an H-1337 ophthalmic solution in subjects with primary open-angle glaucoma (POAG) or ocular hypertension (OHT).DesignThis was a phase I/II, randomized, double-masked, vehicle-controlled, dose-response s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f1354718658aa2f4ba91fbb21c4e60
https://doi.org/10.1016/j.ogla.2022.08.015
https://doi.org/10.1016/j.ogla.2022.08.015
Autor:
Hiroki Shoji, Yoko Yoshida, Takayuki Jujo Sanada, Akira Naito, Junko Maruyama, Erquan Zhang, Kengo Sumi, Seiichiro Sakao, Kazuo Maruyama, Hiroyoshi Hidaka, Koichiro Tatsumi
Publikováno v:
Cells, Vol 11, Iss 1, p 66 (2021)
Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary arterial pressure and right heart failure. Selective pulmonary vasodilators have improved the prognosis of PAH; however, they are not able to reverse pulmonary vascular remo
Externí odkaz:
https://doaj.org/article/c606b099d8604ba3880cb1ddc26466da
Autor:
Hideo Yoshida, Yuka Ashikawa, Shinsuke Itoh, Takashi Nakagawa, Akimune Asanuma, Sohei Tanabe, Yoshihiro Inoue, Hiroyoshi Hidaka
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46432 (2012)
BACKGROUND:K-134 is a more potent antiplatelet drug with a selective inhibitory effect on phosphodiesterase 3 (PDE3) compared with its analogue, cilostazol. OBJECTIVES:This study was performed to compare the ameliorating effects of K-134 and cilostaz
Externí odkaz:
https://doaj.org/article/edf9434b38684428a37d1136decbec79
Autor:
Masaaki Suzuki, Hiroko Koyama, Misato Takashima-Hirano, Takafumi Yamaoka, Hisashi Doi, Hiroyoshi Hidaka, Hiroko Nagata, Kengo Sumi
Publikováno v:
Tetrahedron. 68:2336-2341
A novel PET probe, [11C]H-1152, specific for Rho-kinases, was synthesized efficiently for the first time based on rapid Pd0-mediated C-[11C]methylation using [11C]methyl iodide and a tributylstannyl precursor, giving the isolated radioactivity of 3.8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2b60a9b868012ab635fad229fea777
https://doi.org/10.1016/j.tet.2012.01.033
https://doi.org/10.1016/j.tet.2012.01.033
Autor:
Hiroyoshi Hidaka, Masakatsu Nishikawa
Publikováno v:
Japanese Journal of Thrombosis and Hemostasis. 22:363-367
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ca767612f9ad226a7dde4c39477ebc
https://doi.org/10.2491/jjsth.22.363
https://doi.org/10.2491/jjsth.22.363
Autor:
Kengo Sumi, Masahiro Nishio, Hiroyoshi Hidaka, Yukitaka Uji, Masahiko Sugimoto, Kengo Ikesugi, Takaki Fukunaga
Publikováno v:
Current Eye Research. 34:282-286
We wanted to determine the intraocular pressure (IOP)-lowering effect of H-1152P by utilizing a rabbit ocular hypertension-glaucoma model and normal eyes. H-1152P is a potent, Rho-associated, coiled, coil-forming protein kinase (ROCK) inhibitor.IOPs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b57b3e31ebdba29b38dcc2d7b64349
https://doi.org/10.1080/02713680902783763
https://doi.org/10.1080/02713680902783763
Autor:
Masami Shiratsuchi, Takatoshi Ozawa, Hiroyoshi Hidaka, Masahiro Tamura, Hajime Yamada, Hiromichi Shigyo, Totsuka Junko, Hiroshi Nakao, Hideo Yoshizaki
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1754:245-252
Hexahydro-1-(isoquinoline-5-sulfonyl)-1H-1,4-diazepine, HA-1077, is a known selective inhibitor of Rho-kinase. Although its IC(50) value against Rho-kinase is more than 10 times lower than those for kinases such as PKA, PKB, PKC, PKG, MLCK, CaMKII an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17002fa84743c5ff3491c710702af144
https://doi.org/10.1016/j.bbapap.2005.06.015
https://doi.org/10.1016/j.bbapap.2005.06.015
Autor:
Tetsuya Abe, Tayo Katano, Yasuharu Sasaki, Seiji Ito, Shinichi Tatsumi, Toshiaki Minami, Hiroyoshi Hidaka, Shinji Matsumura, Tamaki Mabuchi, Masaaki Suzuki
Publikováno v:
Neuroscience. 131:491-498
Myristoylated alanine-rich C-kinase substrate (MARCKS) is a major in vivo substrate for protein kinase C in the brain and has been implicated in cellular processes associated with cytoskeletal restructuring such as synaptic trafficking and neurotrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9f52bf0b31f364b607518136db9f35
https://doi.org/10.1016/j.neuroscience.2004.10.022
https://doi.org/10.1016/j.neuroscience.2004.10.022
Autor:
Hitoshi Hishida, Hisahide Takahashi, Keiko Hotta, Hiroyoshi Hidaka, Nobuki Hayakawa, Toshio Tanaka, Michiko Naka, Rumi Masunaga, Akio Nagasaka, Yasuhito Shimada, Yasuchika Kato, Y Sawai, Mitsuyasu Itoh, A. Nakai
Publikováno v:
Journal of Molecular and Cellular Cardiology. 37:767-774
Cyclic nucleotides (cAMP and cGMP) phosphodiesterase (PDE) activities and expression are altered in the cardiac muscle of cardiomyopathic heart failure, and PDE inhibitors improve the abnormal muscle condition through changing the cyclic nucleotide c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87aa17e7a8b403df4f974753dc562f9f
https://doi.org/10.1016/j.yjmcc.2004.06.013
https://doi.org/10.1016/j.yjmcc.2004.06.013
Autor:
Robert Huber, Volker Kinzel, Michael Gassel, C.B. Breitenlechner, Dirk Bossemeyer, Hiroyoshi Hidaka, Richard A. Engh
Publikováno v:
Structure. 11(12):1595-1607
Protein kinases require strict inactivation to prevent spurious cellular signaling; overactivity can cause cancer or other diseases and necessitates selective inhibition for therapy. Rho-kinase is involved in such processes as tumor invasion, cell ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344aac922812e4eeac26cd845513a3b6