Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Hiroyasu Sakai"'
Autor:
Risako Kon, Nobutomo Ikarashi, Mayumi Ohkuma, Misato Toyonaga, Rei Tomimoto, Hiroyasu Sakai, Tomoo Hosoe, Junzo Kamei
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-9 (2024)
Abstract Objectives Apples are one of the most frequently consumed fruits and are effective in preventing lifestyle-related and other diseases. However, few studies have been conducted to evaluate health benefits of processed apple products such as j
Externí odkaz:
https://doaj.org/article/cb2ae99efcfb4c738b0eb7d42df9ccfe
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-8 (2023)
Abstract Objective Placental extract, which contains various bioactive compounds, has been used as traditional medicine. Many studies have demonstrated additional applications of placental extract and provided a scientific basis for the broad spectru
Externí odkaz:
https://doaj.org/article/33c726d3a492461aab30d27f3c3d1bb2
Autor:
Daisuke Taguchi, Yohei Shirakami, Hiroyasu Sakai, Toshihide Maeda, Takao Miwa, Masaya Kubota, Kenji Imai, Takashi Ibuka, Masahito Shimizu
Publikováno v:
Nutrients, Vol 16, Iss 15, p 2506 (2024)
More effective treatments for hepatitis viral infections have led to a reduction in the incidence of liver cirrhosis. A high-fat diet can lead to chronic hepatitis and liver fibrosis, but the effects of lipid intake on liver disease status, including
Externí odkaz:
https://doaj.org/article/f060dc5f03f04940b68bd1ce2a4e9e0c
Autor:
Ken Sato, Yu Miyauchi, Xinran Xu, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Tomoo Hosoe, Hiroyasu Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 3, Pp 167-177 (2023)
Cisplatin, a platinum-based anticancer drug used frequently in cancer treatment, causes skeletal muscle atrophy. It was predicted that the proteolytic pathway is enhanced as the mechanism of this atrophy. Therefore, we investigated whether a platinum
Externí odkaz:
https://doaj.org/article/e1546edfafe64459b2b340fe15163c8e
Autor:
Risako Kon, Nobutomo Ikarashi, Arisa Yamaguchi, Yuka Teshima, Tamami Yamaguchi, Kanako Miyaoka, Moeno Fukuda, Hinata Noguchi, Rei Tomimoto, Hiroyasu Sakai, Junzo Kamei, Tomoo Hosoe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Irinotecan (CPT-11) is an anticancer drug with indications for use in treating various cancers, but severe diarrhea develops as a side effect. We investigated the effects of green tea extract (GTE) on CPT-11-induced diarrhea, focusing on β-
Externí odkaz:
https://doaj.org/article/b16f3c60249149e4b6bb0f7dce69a11f
Autor:
Risako Kon, Nobutomo Ikarashi, Kazuhiro Onuma, Zenta Yasukawa, Makoto Ozeki, Hiroyasu Sakai, Junzo Kamei
Publikováno v:
Food Science & Nutrition, Vol 11, Iss 2, Pp 1127-1133 (2023)
Abstract In recent years, the development of functional foods targeting gastrointestinal disorders has been in progress. Partially hydrolyzed guar gum (PHGG), which is a water‐soluble dietary fiber, is known to have a constipation‐improving effec
Externí odkaz:
https://doaj.org/article/edc7d940dc384e4cbfe9ee87885f92a8
Autor:
Yohei Shirakami, Junichi Kato, Masaya Ohnishi, Daisuke Taguchi, Toshihide Maeda, Takayasu Ideta, Masaya Kubota, Hiroyasu Sakai, Hiroyuki Tomita, Takuji Tanaka, Masahito Shimizu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14581 (2023)
Cholangiocarcinoma is the second most common primary cancer of the liver and has a poor prognosis. Various animal models, including carcinogen-induced and genetically engineered rodent models, have been established to clarify the mechanisms underlyin
Externí odkaz:
https://doaj.org/article/f63d523de7fa4a5996c33f0849fa1f6c
Autor:
Hiroyasu Sakai, Maho Asami, Hiroaki Naito, Satoko Kitora, Yuta Suzuki, Yu Miyauchi, Rei Tachinooka, Satoshi Yoshida, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1570-1581 (2021)
Abstract Background A reduction in the skeletal muscle mass worsens the prognosis of patients with various cancers. Our previous studies indicated that cisplatin administration to mice caused muscle atrophy. This is a concern for human patients recei
Externí odkaz:
https://doaj.org/article/77d597eb59bb4aeea8cec217cc2abbe3
Autor:
Burhan Uyanik, Anastasia R. Goloudina, Aamir Akbarali, Bogdan B. Grigorash, Alexey V. Petukhov, Sunil Singhal, Evgeniy Eruslanov, Jeanne Chaloyard, Lisa Lagorgette, Tarik Hadi, Ekaterina V. Baidyuk, Hiroyasu Sakai, Lino Tessarollo, Bernhard Ryffel, Sharlyn J. Mazur, Frederic Lirussi, Carmen Garrido, Ettore Appella, Oleg N. Demidov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cancers. Here the authors show that inactivation of Wip1 in neutrophils promotes p53-dependent expression of co-stimulatory ligands and anti-tumor immune r
Externí odkaz:
https://doaj.org/article/ce056f276c7b4010b02dce368383e9c8
Autor:
Tsuneyuki Miyazaki, Yohei Shirakami, Taku Mizutani, Akinori Maruta, Takayasu Ideta, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Salvatore Genovese, Serena Fiorito, Vito Alessandro Taddeo, Francesco Epifano, Takuji Tanaka, Masahito Shimizu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands of FXR. FXR activation has recently been reported to inhibit intestinal inflammation and tumour development. This study aimed to investigate whether th
Externí odkaz:
https://doaj.org/article/7ce700ce2ce149d58144ddadc34ce01f