Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Hiroyasu Konno"'
Autor:
Hiroyasu Konno, Ivan K. Chinn, Diana Hong, Jordan S. Orange, James R. Lupski, Alejandra Mendoza, Luis A. Pedroza, Glen N. Barber
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1112-1123 (2018)
Summary: The cellular sensor stimulator of interferon genes (STING) initiates type I interferon (IFN) and cytokine production following association with cyclic dinucleotides (CDNs) generated from intracellular bacteria or via a cellular synthase, cGA
Externí odkaz:
https://doaj.org/article/77b4afacaaf94d418b43d4c16696a0bb
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Cyclic dimeric adenosine 3′,5′-monophosphate (c-di-AMP), a recently identified secondary messenger in bacteria, plays a role in several bacterial processes, including biofilm formation. It is enzymatically produced by diadenylate cyclase and clea
Externí odkaz:
https://doaj.org/article/1e2a0dac0fd94012a289709393179ad7
Autor:
Kojiro Mukai, Hiroyasu Konno, Tatsuya Akiba, Takefumi Uemura, Satoshi Waguri, Toshihide Kobayashi, Glen N. Barber, Hiroyuki Arai, Tomohiko Taguchi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
STING is essential for the type I interferon immune response to foreign DNA. Here, the authors show that palmitoylation of STING at the Golgi is required for activating downstream signalling, and increased Golgi localization of certain STING variants
Externí odkaz:
https://doaj.org/article/005c19e978c34d6c8e60b4bff03ce1f4
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 282-297 (2016)
Stimulator of interferon genes (STING) has been shown to be critical for controlling antiviral responses as well as anti-tumor adaptive immunity, but little is known regarding its regulation in human tumors. Here, we report that STING signaling is re
Externí odkaz:
https://doaj.org/article/86ab4ae797ff47eface02033b1cf724c
Autor:
Taishin Akiyama, Takuma Shiraishi, Junwen Qin, Hiroyasu Konno, Nobuko Akiyama, Miho Shinzawa, Maki Miyauchi, Nobukazu Takizawa, Hiromi Yanai, Hiroyuki Ohashi, Etsuko Miyamoto-Sato, Hiroshi Yanagawa, Weidong Yong, Weinian Shou, Jun-Ichiro Inoue
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95992 (2014)
Virus-derived double-stranded RNAs (dsRNAs) are sensed in the cytosol by retinoic acid-inducible gene (RIG)-I-like receptors (RLRs). These induce the expression of type I IFN and proinflammatory cytokines through signaling pathways mediated by the mi
Externí odkaz:
https://doaj.org/article/f1776162c5cc4135bc17b28a1096c26c
Autor:
Hiroyasu Konno, Takuya Yamamoto, Kohsuke Yamazaki, Jin Gohda, Taishin Akiyama, Kentaro Semba, Hideo Goto, Atsushi Kato, Toshiaki Yujiri, Takahiko Imai, Yasushi Kawaguchi, Bing Su, Osamu Takeuchi, Shizuo Akira, Yasuko Tsunetsugu-Yokota, Jun-ichiro Inoue
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5674 (2009)
BACKGROUND:In response to viral infection, the innate immune system recognizes viral nucleic acids and then induces production of proinflammatory cytokines and type I interferons (IFNs). Toll-like receptor 7 (TLR7) and TLR9 detect viral RNA and DNA,
Externí odkaz:
https://doaj.org/article/cfaf5f60a1dd48d58ec0a139c6d551d9
Autor:
Hiroyasu Konno, Tracey Lin, Renyi Wu, Xinchuan Dai, Shou Li, Grace Wang, Min Chen, Wenying Li, Lina Wang, Bee-Chun Sun, Zhen Luo, Tom Huang, Yuping Chen, John Zhang, Qiuping Ye, David Bellovin, Bing Wan, Lishan Kang, Christopher Szeto, Karl Hsu, Omar Kabbarah
Publikováno v:
Cancer Research Communications. 2:937-950
CLDN18.2 (Claudin18.2)-targeting therapeutic antibodies have shown promising clinical efficacy in approximately 30% of gastric cancers expressing high levels of CLDN18.2 and less pronounced activity in low expressing malignancies. Here, we report tha
Autor:
Omar Kabbarah, Karl Hsu, Christopher Szeto, Lishan Kang, Bing Wan, David Bellovin, Qiuping Ye, John Zhang, Yuping Chen, Tom Huang, Zhen Luo, Bee-Chun Sun, Lina Wang, Wenying Li, Min Chen, Grace Wang, Shou Li, Xinchuan Dai, Renyi Wu, Tracey Lin, Hiroyasu Konno
Supplementary Figure 3 shows CLDN18.2 expression in gastric tumor cell lines and ZL-1211-induced CDC for the gastric tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ece513e5fc0cdda7cbc6e0c61ed145
https://doi.org/10.1158/2767-9764.22545576
https://doi.org/10.1158/2767-9764.22545576
Autor:
Omar Kabbarah, Karl Hsu, Christopher Szeto, Lishan Kang, Bing Wan, David Bellovin, Qiuping Ye, John Zhang, Yuping Chen, Tom Huang, Zhen Luo, Bee-Chun Sun, Lina Wang, Wenying Li, Min Chen, Grace Wang, Shou Li, Xinchuan Dai, Renyi Wu, Tracey Lin, Hiroyasu Konno
CLDN18.2 (Claudin18.2)-targeting therapeutic antibodies have shown promising clinical efficacy in approximately 30% of gastric cancers expressing high levels of CLDN18.2 and less pronounced activity in low expressing malignancies. Here, we report tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23593d81e787887277aaaf7ae7488821
https://doi.org/10.1158/2767-9764.c.6550980
https://doi.org/10.1158/2767-9764.c.6550980
Ovarian cells infected with HSV1 expressing luciferase (HSV-luc).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07063024b16a02de922b57a94976c79d
https://doi.org/10.1158/1541-7786.22512496.v1
https://doi.org/10.1158/1541-7786.22512496.v1