Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hiroya Muranishi"'
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(7)
Delivering new medicines to patients suffering from Neglected Tropical Diseases (NTD) is a major challenge. There are various hurdles to be overcome, such as the large number of patients in a large number of different regions, the lack of marketabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf730f94cd54b3f265159f642d1fbdec
https://pubmed.ncbi.nlm.nih.gov/35781496
https://pubmed.ncbi.nlm.nih.gov/35781496
Publikováno v:
Journal of Pharmaceutical Sciences. 90:2121-2130
The benzothiepin derivative (2R,4S)‐(‐)‐N‐(4‐diethoxyphosphorylmethylphenyl)‐1,2,4,5‐tetrahydro‐4‐methyl‐7,8‐methylenedioxy‐5‐oxo‐3‐benzothiepin‐2‐carboxamide (TAK‐778) is a potent bone formation stimulant. A susta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4259e3018dc37aeb2fd5eb656b2374
https://doi.org/10.1002/jps.1163
https://doi.org/10.1002/jps.1163
Autor:
Tetsuo Hoshino, Hirofumi Nagai, Haruhiko Makino, Yasuaki Ogawa, Hiroya Muranishi, Kazuhiro Saito, Takashi Sohda, Kohei Notoya
Publikováno v:
Journal of Biomedical Materials Research. 51:299-306
The feasibility of using microcapsules containing a bone formation stimulant, (2R,4S)-(−)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxamide (TAK-778) to enhance fracture repair wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498bcb4ee97021a6ad14b9e7c8433675
https://doi.org/10.1002/1097-4636(20000905)51:3<299::aid-jbm2>3.0.co
https://doi.org/10.1002/1097-4636(20000905)51:3<299::aid-jbm2>3.0.co
Publikováno v:
Biological and Pharmaceutical Bulletin. 16:1031-1034
The dose-dependent uptake of fractionated 3H-heparin in the subpopulations of liver cells, parenchymal and non-parenchymal cells, was characterized in rats in vivo. Following the intravenous administration of fractionated 3H-heparin, the radioactivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113d1926c34f7eab0b60526b88583f9b
https://doi.org/10.1248/bpb.16.1031
https://doi.org/10.1248/bpb.16.1031
Publikováno v:
Biological and Pharmaceutical Bulletin. 16:497-500
In order to elucidate the uptake mechanism of fractionated [3H]heparin by rat parenchymal hepatocytes, the concentration dependent uptake was kinetically analyzed in primary culture of rat parenchymal hepatocytes, and the effects of established trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6376ff20d71f428e2647f2037c3b6a
https://doi.org/10.1248/bpb.16.497
https://doi.org/10.1248/bpb.16.497
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:3052-3055
The uptake of fractionated [3H]heparin was investigated in rat parenchymal hepatocytes in primary culture. The initial uptake of fractionated [3H]heparin was found to be saturable with the maximum uptake velocity (Vmax) of 10.1 +/- 1.46 pmol/min/mg p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae585d7af99c3d5170b989203826c8d3
https://doi.org/10.1248/cpb.40.3052
https://doi.org/10.1248/cpb.40.3052
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:2821-2824
The effect of alpha-globulin, the dominant binding protein for fractionated 3H-heparin, on the hepatic uptake of 3H-heparin was studied by liver perfusion experiments in rats. Fractionated 3H-heparin concentration in the recirculated perfusate declin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e735f966848e3e52a952cd4ab1deb3
https://doi.org/10.1248/cpb.38.2821
https://doi.org/10.1248/cpb.38.2821
Publikováno v:
Biological and Pharmaceutical Bulletin. 16:939-941
The distribution of fractionated heparin in a primary culture of rat parenchymal hepatocytes was investigated optically using the fluorescence labelled drug and confocal imaging system with an inverted fluorescence microscope. The cell-associated flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ba695001042a770b3d119d9d38d935
https://doi.org/10.1248/bpb.16.939
https://doi.org/10.1248/bpb.16.939
Publikováno v:
Biologicalpharmaceutical bulletin. 18(3)
The uptake of low molecular weight fractionated [3H]heparin (LMWFH: 7000 Da) was examined, for comparison with that of high molecular weight fractionated [3H]heparin (HMWFH:20000 Da), in a primary culture of rat hepatocytes. The uptake of LMWFH incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9aaff0548d8b6720f15e70c145d6a6
https://pubmed.ncbi.nlm.nih.gov/7550100
https://pubmed.ncbi.nlm.nih.gov/7550100
Publikováno v:
Biologicalpharmaceutical bulletin. 16(10)
The concentration-dependent hepatic uptake of fractionated [3H]heparin, a macromolecular model drug, was kinetically characterized and the effect of plasma proteins, albumin and α-globulin, was evaluated in the perfused rat liver as part of an ongoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e314728be35078d31ded4943968d07f
https://pubmed.ncbi.nlm.nih.gov/8287034
https://pubmed.ncbi.nlm.nih.gov/8287034